Biography

Dr. Zhang obtained his Bachelor’s degree from Wuhan University in China in 2001 followed by a Ph.D study working with Dr. Jennifer Grandis at Department of Pharmacology, University of Pittsburgh School of Medicine until Late 2005. From 2006 to early 2013, He worked as a postdoctoral fellow (2006-06/2011) and an instructor (07/2011-01/2013) in the lab of The Nobel Laureate Dr. William Kaelin Jr. at Dana Farber Cancer Institute on prolyl hydroxylase and oxygen sensing pathway in cancer. He became an assistant professor at Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill in Feb of 2013. He was promoted to associate professor with tenure in Feb of 2019 at UNC Chapel Hill and now he is an associate professor with tenure in the Department of Pathology at UT Southwestern Medical Center in Dallas. He is currently holding the title of Cancer Prevention & Research Institute of Texas (CPRIT) Scholar in Cancer Research.

His research has been continuously funded by the National Institute of Health. Currently his research is supported by the National Cancer Institute, Department of Defense (DOD), American Cancer Society (ACS), CPRIT as well as Kidney Cancer Research Alliance (KCCure).

He is a member of both the American Society for Investigative Pathology (ASIP) and American Association for Cancer Research (AACR). He obtained various awards, including CPRIT Rising Star Award, ASIP Ramzi Cotran Early Career Investigator Award, DOD KCRP Idea Development Award, ACS Research Scholar Award, Kimmel Scholar Award, V Scholar Award, Susan. G. Komen Career Catalyst Award and Mary Kay Foundation Award. He also served as the Associate Scientific Advisor at Science Translational Medicine.

Education

Graduate School
University of Pittsburgh (2005)

Research Interest

  • kidney cancer, breast cancer, hypoxia signaling, VHL, post-translational modification

Publications

Featured Publications LegendFeatured Publications

Combined inhibition of PLC{gamma}-1 and c-Src abrogates epidermal growth factor receptor-mediated head and neck squamous cell carcinoma invasion.
Nozawa H, Howell G, Suzuki S, Zhang Q, Qi Y, Klein-Seetharaman J, Wells A, Grandis JR, Thomas SM, Clin. Cancer Res. 2008 Jul 14 13 4336-44
Autocrine and paracrine chemokine receptor 7 activation in head and neck cancer: implications for therapy.
Wang J, Seethala RR, Zhang Q, Gooding W, van Waes C, Hasegawa H, Ferris RL, J. Natl. Cancer Inst. 2008 Apr 100 7 502-12
Immunohistochemical analysis of phosphotyrosine signal transducer and activator of transcription 3 and epidermal growth factor receptor autocrine signaling pathways in head and neck cancers and metastatic lymph nodes.
Seethala RR, Gooding WE, Handler PN, Collins B, Zhang Q, Siegfried JM, Grandis JR, Clin. Cancer Res. 2008 Mar 14 5 1303-9
VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.
Young AP, Schlisio S, Minamishima YA, Zhang Q, Li L, Grisanzio C, Signoretti S, Kaelin WG, Nat. Cell Biol. 2008 Mar 10 3 361-9
Antitumor mechanisms of combined gastrin-releasing peptide receptor and epidermal growth factor receptor targeting in head and neck cancer.
Zhang Q, Bhola NE, Lui VW, Siwak DR, Thomas SM, Gubish CT, Siegfried JM, Mills GB, Shin D, Grandis JR, Mol. Cancer Ther. 2007 Apr 6 4 1414-24
Cross-talk between G protein-coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinoma.
Thomas SM, Bhola NE, Zhang Q, Contrucci SC, Wentzel AL, Freilino ML, Gooding WE, Siegfried JM, Chan DC, Grandis JR, Cancer Res. 2006 Dec 66 24 11831-9
Decreased STAT1 expression by promoter methylation in squamous cell carcinogenesis.
Xi S, Dyer KF, Kimak M, Zhang Q, Gooding WE, Chaillet JR, Chai RL, Ferrell RE, Zamboni B, Hunt J, Grandis JR, J. Natl. Cancer Inst. 2006 Feb 98 3 181-9
Constitutive activation of Stat5b contributes to carcinogenesis in vivo.
Xi S, Zhang Q, Gooding WE, Smithgall TE, Grandis JR, Cancer Res. 2003 Oct 63 20 6763-71
Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by activation of the epidermal growth factor receptor.
Lui VW, Thomas SM, Zhang Q, Wentzel AL, Siegfried JM, Li JY, Grandis JR, Oncogene 2003 Sep 22 40 6183-93
Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck.
Xi S, Zhang Q, Dyer KF, Lerner EC, Smithgall TE, Gooding WE, Kamens J, Grandis JR, J. Biol. Chem. 2003 Aug 278 34 31574-83

Honors & Awards

  • ASIP Ramzi Cotran Early Career Investigator Award
    (2020)
  • CPRIT Rising Star Award
    (2019-2024)
  • UT System Rising STARs Award
    (2019-2022)
  • American Cancer Society Research Scholar
    (2018-2022)
  • Associate Scientific Advisor, Science Translational Medicine
    (2018)
  • Susan G. Komen Career Catalyst Award
    (2015-2018)
  • The V Scholar Award
    (2015-2017)
  • Kimmel Scholar Award
    (2014-2016)

Professional Associations/Affiliations

  • American Society for Investigative Pathology (2015)
  • American Association for Cancer Research (2006)