Qing Zhang, Ph.D. Titles and Appointments Director of Investigative Pathology, Department of Pathology, UTSW | Chief Scientific Officer (CSO), Breast Cancer Research Program, UTSW Cancer Center | Co-Director, Career Enhancement Program, Kidney Cancer Program, UTSW Professor Endowed Title Komen Distinguished Chair in Basic Breast Cancer Research School Medical School Department Pathology Graduate Programs Cancer Biology, Genetics, Development and Disease Biography Dr. Zhang obtained his Bachelor’s degree from Wuhan University in China in 2001 followed by a Ph.D study working with Dr. Jennifer Grandis at Department of Pharmacology, University of Pittsburgh School of Medicine until Late 2005. From 2006 to early 2013, He worked as a postdoctoral fellow (2006-06/2011) and an instructor (07/2011-01/2013) in the lab of Nobel Laureate Dr. William Kaelin Jr. at Dana Farber Cancer Institute on prolyl hydroxylase and oxygen sensing pathway in cancer. He became an assistant professor at Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill in Feb of 2013. He was promoted to associate professor with tenure in Feb of 2019 at UNC Chapel Hill and now he is a professor with tenure in the Department of Pathology at UT Southwestern Medical Center (UTSW) in Dallas. He is currently holding the title of Cancer Prevention & Research Institute of Texas (CPRIT) Scholar in Cancer Research and Komen Distinguished Chair in Basic Breast Cancer Research at UTSW. In addition, he also serves as the chief scientific officer (CSO) for breast cancer research program as well as co-director for career enhancement program at kidney cancer specialized program of research excellence (SPORE) in Simmons Comprehensive Cancer Center at UTSW. His research has been continuously funded by the National Institute of Health. Currently his research is supported by the National Cancer Institute, American Association for Cancer Research (AACR), DoD and CPRIT. He has also been previously supported by American Cancer Society (ACS), V foundation, Susan G Komen Foundation, Mary Kay Foundation, Sidney Kimmel Foundation and Kidney Cancer Research Alliance (KCCure). He is a member of the American Society for Investigative Pathology (ASIP), AACR and American Society of Biochemistry and Molecular Biology (ASBMB). He obtained various awards, including CPRIT Rising Star Award, ASIP Ramzi Cotran Early Career Investigator Award, ASIP Outstanding Investigator Award, DOD KCRP Idea Development Award, ACS Research Scholar Award, Kimmel Scholar Award, V Scholar Award, Susan. G. Komen Career Catalyst Award and Mary Kay Foundation Award. He also served as the Associate Scientific Advisor at Science Translational Medicine. He served as a programmatic panel member for DoD kidney cancer research program from 2022-2023. Recently he served as a chartered member of NIH Biochemical and Cellular Oncogenesis (BCO) study section. He currently serves as charted member for ACS Tumor Biochemistry and Endocrinolgy (TBE). Education Undergraduate Wuhan University (2001), Biochemistry Graduate School University of Pittsburgh (2005), Pharmacology Research Interest kidney cancer, breast cancer, hypoxia signaling, VHL, post-translational modification Publications Featured Publications BBOX1 restrains TBK1-mTORC1 oncogenic signaling in clear cell renal cell carcinoma. Liao C, Hu L, Jia L, Zhou J, Wang T, Kim K, Zhong H, Yao H, Dong L, Guo L, Liang Q, Zhang C, Zhao F, Fang J, Liu H, Li S, Xu L, Simon JM, Malladi S, Kapur P, Brugarolas J, DeBerardinis RJ, Zhang Q, Nat Commun 2025 Feb 16 1 1543 Von Hippel-Lindau protein signalling in clear cell renal cell carcinoma. Liao C, Hu L, Zhang Q, Nat Rev Urol 2024 May Von Hippel Lindau tumor suppressor controls m6A-dependent gene expression in renal tumorigenesis. Zhang C, Yu M, Hepperla AJ, Zhang Z, Raj R, Zhong H, Zhou J, Hu L, Fang J, Liu H, Liang Q, Jia L, Liao C, Xi S, Simon JM, Xu K, Liu Z, Nam Y, Kapur P, Zhang Q, J Clin Invest 2024 Apr 134 8 Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma. Hu L, Zhang Y, Guo L, Zhong H, Xie L, Zhou J, Liao C, Yao H, Fang J, Liu H, Zhang C, Zhang H, Zhu X, Luo M, von Kriegsheim A, Li B, Luo W, Zhang X, Chen X, Mendell JT, Xu L, Kapur P, Baldwin AS, Brugarolas J, Zhang Q, Mol Cell 2024 Jan Histone H3 proline 16 hydroxylation regulates mammalian gene expression. Liu X, Wang J, Boyer JA, Gong W, Zhao S, Xie L, Wu Q, Zhang C, Jain K, Guo Y, Rodriguez J, Li M, Uryu H, Liao C, Hu L, Zhou J, Shi X, Tsai YH, Yan Q, Luo W, Chen X, Strahl BD, von Kriegsheim A, Zhang Q, Wang GG, Baldwin AS, Zhang Q, Nat Genet 2022 Nov USP13 promotes deubiquitination of ZHX2 and tumorigenesis in kidney cancer. Xie H, Zhou J, Liu X, Xu Y, Hepperla AJ, Simon JM, Wang T, Yao H, Liao C, Baldwin AS, Gong K, Zhang Q, Proc Natl Acad Sci U S A 2022 Sep 119 36 e2119854119 An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma. Zhou J, Simon JM, Liao C, Zhang C, Hu L, Zurlo G, Liu X, Fan C, Hepperla A, Jia L, Tcheuyap VT, Zhong H, Elias R, Ye J, Henne WM, Kapur P, Nijhawan D, Brugarolas J, Zhang Q, Mol Cell 2022 Jun Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers. Liao C, Glodowski CR, Fan C, Liu J, Mott KR, Kaushik A, Vu H, Locasale JW, McBrayer SK, DeBerardinis RJ, Perou CM, Zhang Q, Cancer Res 2021 Dec ZHX2 promotes HIF1a oncogenic signaling in triple-negative breast cancer. Fang W, Liao C, Shi R, Simon JM, Ptacek TS, Zurlo G, Ye Y, Han L, Fan C, Bao L, Ortiz CL, Lin HR, Manocha U, Luo W, Kim WY, Yang LW, Zhang Q, Elife 2021 Nov 10 Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer. Liao C, Zhang Y, Fan C, Herring LE, Liu J, Locasale JW, Takada M, Zhou J, Zurlo G, Hu L, Simon JM, Ptacek TS, Andrianov VG, Loza E, Peng Y, Yang H, Perou CM, Zhang Q, Cancer Discov 2020 Jul Results 1-10 of 51 1 2 3 4 5 Next Last Honors & Awards ASIP Outstanding Investigator Award (2024) CBIS Young Investigator Award (2024) ASIP Ramzi Cotran Early Career Investigator Award (2020) CPRIT Rising Star Award (2019-2024) UT System Rising STARs Award (2019-2022) American Cancer Society Research Scholar (2018-2022) Associate Scientific Advisor, Science Translational Medicine (2018) Susan G. Komen Career Catalyst Award (2015-2018) The V Scholar Award (2015-2017) Kimmel Scholar Award (2014-2016) Professional Associations/Affiliations American Association for Cancer Research (2006) American Society for Biochemistry and Molecular Biology American Society for Investigative Pathology (2015)
