Biography

Since November 2019, Jian Zhou has been appointed as Assistant Professor in the Lyda Hill Department of Bioinformatics. He is a Lupe Murchison Foundation Scholar in Medical Research and is a Scholar of the Cancer Prevention and Research Institute of Texas (CPRIT). Prior to joining UTSW, he was a Flatiron Research Fellow at the Center of Computational Biology at Flatiron Institute, New York. He received his B.S. in Biological Sciences from Peking University and Ph.D. in Quantitative and Computational Biology from Princeton University.

The Zhou lab works at the intersection of machine learning and genomics. The lab develops computational methods to improve our understanding of genome-based regulation and the genetic basis of human health and diseases.  Advancing machine learning and AI methods for science, especially genomics is a long-term goal of the lab. Visit the lab website for more details https://zhoulab.io.

 

 

 

Research Interest

  • Decipher gene regulatory program from genomic sequence
  • Developing computational methods for advancing single-cell data analysis
  • Improving machine learning & AI methods for science
  • Sequence-based modeling of 3D genome organization
  • Understand evolution of the regulatory genome

Publications

Featured Publications LegendFeatured Publications

Genome-wide landscape of RNA-binding protein target site dysregulation reveals a major impact on psychiatric disorder risk.
Park CY, Zhou J, Wong AK, Chen KM, Theesfeld CL, Darnell RB, Troyanskaya OG, Nat Genet 2021 02 53 2 166-173
Genomic analyses implicate noncoding de novo variants in congenital heart disease.
Richter F, Morton SU, Kim SW, Kitaygorodsky A, Wasson LK, Chen KM, Zhou J, Qi H, Patel N, DePalma SR, Parfenov M, Homsy J, Gorham JM, Manheimer KB, Velinder M, Farrell A, Marth G, Schadt EE, Kaltman JR, Newburger JW, Giardini A, Goldmuntz E, Brueckner M, Kim R, Porter GA, Bernstein D, Chung WK, Srivastava D, Tristani-Firouzi M, Troyanskaya OG, Dickel DE, Shen Y, Seidman JG, Seidman CE, Gelb BD, Nat Genet 2020 08 52 8 769-777
Accurate genome-wide predictions of spatio-temporal gene expression during embryonic development.
Zhou J, Schor IE, Yao V, Theesfeld CL, Marco-Ferreres R, Tadych A, Furlong EEM, Troyanskaya OG, PLoS Genet. 2019 Sep 15 9 e1008382
Selene: a PyTorch-based deep learning library for sequence data.
Chen KM, Cofer EM, Zhou J, Troyanskaya OG, Nat. Methods 2019 04 16 4 315-318
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
Shrine N, Guyatt AL, Erzurumluoglu AM, Jackson VE, Hobbs BD, Melbourne CA, Batini C, Fawcett KA, Song K, Sakornsakolpat P, Li X, Boxall R, Reeve NF, Obeidat M, Zhao JH, Wielscher M, Weiss S, Kentistou KA, Cook JP, Sun BB, Zhou J, Hui J, Karrasch S, Imboden M, Harris SE, Marten J, Enroth S, Kerr SM, Surakka I, Vitart V, Lehtimäki T, Allen RJ, Bakke PS, Beaty TH, Bleecker ER, Bossé Y, Brandsma CA, Chen Z, Crapo JD, Danesh J, DeMeo DL, Dudbridge F, Ewert R, Gieger C, Gulsvik A, Hansell AL, Hao K, Hoffman JD, Hokanson JE, Homuth G, Joshi PK, Joubert P, Langenberg C, Li X, Li L, Lin K, Lind L, Locantore N, Luan J, Mahajan A, Maranville JC, Murray A, Nickle DC, Packer R, Parker MM, Paynton ML, Porteous DJ, Prokopenko D, Qiao D, Rawal R, Runz H, Sayers I, Sin DD, Smith BH, Soler Artigas M, Sparrow D, Tal-Singer R, Timmers PRHJ, Van den Berge M, Whittaker JC, Woodruff PG, Yerges-Armstrong LM, Troyanskaya OG, Raitakari OT, Kähönen M, Pola?ek O, Gyllensten U, Rudan I, Deary IJ, Probst-Hensch NM, Schulz H, James AL, Wilson JF, Stubbe B, Zeggini E, Jarvelin MR, Wareham N, Silverman EK, Hayward C, Morris AP, Butterworth AS, Scott RA, Walters RG, Meyers DA, Cho MH, Strachan DP, Hall IP, Tobin MD, Wain LV, Nat. Genet. 2019 03 51 3 481-493
Organoid single cell profiling identifies a transcriptional signature of glomerular disease.
Harder JL, Menon R, Otto EA, Zhou J, Eddy S, Wys NL, O'Connor C, Luo J, Nair V, Cebrian C, Spence JR, Bitzer M, Troyanskaya OG, Hodgin JB, Wiggins RC, Freedman BS, Kretzler M, JCI Insight 2019 Jan 4 1

Honors & Awards

  • NIH Director's New Innovator Award
    (2021)