Mahesh Kathania, Ph.D. Instructor School Medical School Department Internal Medicine Biography Mahesh Kathania, Ph.D., is an Instructor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of its Division of Digestive and Liver Diseases. Originally from Pilani, India, Dr. Kathania holds a master's degree in biochemistry from the University of Rajasthan. He earned his doctoral degree in cell biology and immunology at the Institute of Microbial Technology at Chandigarh. He completed an immunology and cell signaling fellowship at the University of Florida followed by a fellowship at Baylor Institute for Immunology Research in Dallas. Dr. Kathania joined the UT Southwestern faculty in 2024. Dr. Kathania's research interests include colon cancer, gut microbiota, inflammatory bowel diseases, and CAR T-cell therapy. He is currently working on understanding the role of novel transcription factors in regulation of T cell exhaustion. Dr. Kathania is active in several in professional societies, including the American Association of Immunologists and the Asain Council of Scientific Editors. Dr. Kathania's interests outside of research include traveling and enjoying time with family. Research Interest CAR T-cell therapy Colon Cancer Gut Microbiota Inflammatory Bowel Diseases Publications RORγt-Raftlin1 complex regulates the pathogenicity of Th17 cells and colonic inflammation Singh AK, Kumar R, Yin J, Brooks JF, Kathania M, Mukherjee S, Kumar J, Conlon KP, Basrur V, Chen Z, Han X, Hooper LV, Burstein E, Venuprasad K Nature communications 2023 Dec 14 Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation Kathania M, Kumar R, Lenou ET, Basrur V, Theiss AL, Chernoff J, Venuprasad K Cell Reports 2022 Sep 40 Wasting condition as a marker for severe disease in pediatric Crohn's disease Jin W, Yang DH, Tchah H, Kwon KA, Kim JH, Jeong SJ, Hahm KB, Kathania. M Medicine (United States) 2022 May 101 MMP7 as a potential biomarker of colon cancer and its prognostic value by bioinformatics analysis Chen L, Ke X, Kathania M Medicine (United States) 2021 Mar 100 E24953 Deletion of Cbl-b inhibits CD8 + T-cell exhaustion and promotes CAR T-cell function Kumar J, Kumar R, Kumar Singh A, Tsakem EL, Kathania M, Riese MJ, Theiss AL, Davila ML, Venuprasad K Journal for ImmunoTherapy of Cancer 2021 Jan 9 Gut microbiota contributes to spontaneous colitis in e3 ligase itch-deficient mice Kathania M, Tsakem EL, Theiss AL, Venuprasad K Journal of Immunology 2020 Apr 204 2277-2284 SCGN deficiency results in colitis susceptibility Sifuentes-Dominguez L, Li H, Llano E, Liu Z, Singla A, Patel AS, Kathania M, Khoury A, Norris N, Rios JJ, Starokadomskyy P, Park JY, Gopal P, Liu Q, Tan S, Chan L, Ross T, Harrison S, K V, Baker LA, Jia D, Burstein E eLife 2019 Oct 8 IL-17-driven intestinal fibrosis is inhibited by Itch-mediated ubiquitination of HIC-5 Paul J, Singh AK, Kathania M, Elviche TL, Zeng M, Basrur V, Theiss AL, Venuprasad K Mucosal Immunology 2018 Mar 11 427-436 Itch inhibits IL-17-mediated colon inflammation and tumorigenesis by ROR-γt ubiquitination Kathania M, Khare P, Zeng M, Cantarel B, Zhang H, Ueno H, Venuprasad K Nature immunology 2016 Jul 17 997-1004 Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7 Kathania M, Zeng M, Yadav VN, Moghaddam SJ, Yang B, Venuprasad K Journal of Immunology 2015 Mar 194 2160-2167 Results 1-10 of 17 1 2 Next Last Professional Associations/Affiliations American Association of Immunologists (2023) Member of Asian Council of Scientific Editors (2021)
