Katherine Wert, Ph.D.
Assistant Professor

• Embryonic and induced pluripotent stem cells
• Gene therapy
• Genetic mechanisms underlying ocular neurodegeneration
• Genome engineering
• Human stem cell transplantations
• Inherited retinal degenerations
• Metabolism and metabolic reprogramming
• Mouse models of ocular disease
• Retinitis Pigmentosa

Featured Publications

Replenishment of TCA cycle intermediates provides photoreceptor resilience against neurodegeneration during progression of retinitis pigmentosa.

Rowe AA, Patel PD, Gordillo R, Wert KJ, JCI Insight 2021 Jul

Phenotypic variance in Calpain-5 retinal degeneration.

Tang PH, Chemudupati T, Wert KJ, Folk JC, Mahajan M, Tsang SH, Bassuk AG, Mahajan VB, Am J Ophthalmol Case Rep 2020 Jun 18 100627

Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration.

Wert KJ, Velez G, Kanchustambham VL, Shankar V, Evans LP, Sengillo JD, Zare RN, Bassuk AG, Tsang SH, Mahajan VB, EBioMedicine 2020 Feb 52 102636

CAPN5 genetic inactivation phenotype supports therapeutic inhibition trials.

Wert KJ, Koch SF, Velez G, Hsu CW, Mahajan M, Bassuk AG, Tsang SH, Mahajan VB, Hum. Mutat. 2019 Aug

Insights into Retinal Development Using Live Imaging in Female Carriers of Choroideremia.

Wert KJ, Bakall B, Bassuk AG, Tsang SH, Mahajan VB, Ophthalmic Surg Lasers Imaging Retina 2019 May 50 5 e158-e162

Metabolite therapy guided by liquid biopsy proteomics delays retinal degeneration

Wert KJ, Velez G, Vijayalaksmi K, Shankar V, Sengillo JD, Zare RN, Bassuk AG, Tsang SH, Mahajan VB Biorxiv 2019

In Vivo Expression of Mutant Calpains in the Eye Using Lentivirus.

Wert KJ, Mahajan VB, Methods Mol. Biol. 2019 1915 233-247

Extracellular superoxide dismutase (SOD3) regulates oxidative stress at the vitreoretinal interface.

Wert KJ, Velez G, Cross MR, Wagner BA, Teoh-Fitzgerald ML, Buettner GR, McAnany JJ, Olivier A, Tsang SH, Harper MM, Domann FE, Bassuk AG, Mahajan VB, Free Radic. Biol. Med. 2018 08 124 408-419

Establishment of human pluripotent stem cell-derived pancreatic ß-like cells in the mouse pancreas.

Ma H, Wert KJ, Shvartsman D, Melton DA, Jaenisch R, Proc. Natl. Acad. Sci. U.S.A. 2018 04 115 15 3924-3929

Cytotoxic Escherichia coli strains encoding colibactin isolated from immunocompromised mice with urosepsis and meningitis.

Bakthavatchalu V, Wert KJ, Feng Y, Mannion A, Ge Z, Garcia A, Scott KE, Caron TJ, Madden CM, Jacobsen JT, Victora G, Jaenisch R, Fox JG, PLoS ONE 2018 13 3 e0194443

• Stanford University School of Medicine (2017-2019)
• Whitehead Institute for Biomedical Research/MIT (2014-2017)
• Columbia University Graduate School of the Arts and Sciences/Institute of Human Nutrition (2009-2013)
• Columbia University College of Physicians and Surgeons/Institute of Human Nutrition (2008-2009)