
Katherine Wert, Ph.D.
Assistant Professor
Department Ophthalmology | Molecular Biology
Graduate Programs Genetics, Development and Disease, Neuroscience
Research Interest
- Embryonic and induced pluripotent stem cells
- Gene therapy
- Genetic mechanisms underlying ocular neurodegeneration
- Genome engineering
- Human stem cell transplantations
- Inherited retinal degenerations
- Metabolism and metabolic reprogramming
- Mouse models of ocular disease
- Retinitis Pigmentosa
Publications
Featured Publications
- Replenishment of TCA cycle intermediates provides photoreceptor resilience against neurodegeneration during progression of retinitis pigmentosa.
- Rowe AA, Patel PD, Gordillo R, Wert KJ, JCI Insight 2021 Jul
- Phenotypic variance in Calpain-5 retinal degeneration.
- Tang PH, Chemudupati T, Wert KJ, Folk JC, Mahajan M, Tsang SH, Bassuk AG, Mahajan VB, Am J Ophthalmol Case Rep 2020 Jun 18 100627
- Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration.
- Wert KJ, Velez G, Kanchustambham VL, Shankar V, Evans LP, Sengillo JD, Zare RN, Bassuk AG, Tsang SH, Mahajan VB, EBioMedicine 2020 Feb 52 102636
- CAPN5 genetic inactivation phenotype supports therapeutic inhibition trials.
- Wert KJ, Koch SF, Velez G, Hsu CW, Mahajan M, Bassuk AG, Tsang SH, Mahajan VB, Hum. Mutat. 2019 Aug
- Insights into Retinal Development Using Live Imaging in Female Carriers of Choroideremia.
- Wert KJ, Bakall B, Bassuk AG, Tsang SH, Mahajan VB, Ophthalmic Surg Lasers Imaging Retina 2019 May 50 5 e158-e162
- Metabolite therapy guided by liquid biopsy proteomics delays retinal degeneration
- Wert KJ, Velez G, Vijayalaksmi K, Shankar V, Sengillo JD, Zare RN, Bassuk AG, Tsang SH, Mahajan VB Biorxiv 2019
- In Vivo Expression of Mutant Calpains in the Eye Using Lentivirus.
- Wert KJ, Mahajan VB, Methods Mol. Biol. 2019 1915 233-247
- Extracellular superoxide dismutase (SOD3) regulates oxidative stress at the vitreoretinal interface.
- Wert KJ, Velez G, Cross MR, Wagner BA, Teoh-Fitzgerald ML, Buettner GR, McAnany JJ, Olivier A, Tsang SH, Harper MM, Domann FE, Bassuk AG, Mahajan VB, Free Radic. Biol. Med. 2018 08 124 408-419
- Establishment of human pluripotent stem cell-derived pancreatic ß-like cells in the mouse pancreas.
- Ma H, Wert KJ, Shvartsman D, Melton DA, Jaenisch R, Proc. Natl. Acad. Sci. U.S.A. 2018 04 115 15 3924-3929
- Cytotoxic Escherichia coli strains encoding colibactin isolated from immunocompromised mice with urosepsis and meningitis.
- Bakthavatchalu V, Wert KJ, Feng Y, Mannion A, Ge Z, Garcia A, Scott KE, Caron TJ, Madden CM, Jacobsen JT, Victora G, Jaenisch R, Fox JG, PLoS ONE 2018 13 3 e0194443
Professional Associations/Affiliations
- Stanford University School of Medicine (2017-2019)
- Whitehead Institute for Biomedical Research/MIT (2014-2017)
- Columbia University Graduate School of the Arts and Sciences/Institute of Human Nutrition (2009-2013)
- Columbia University College of Physicians and Surgeons/Institute of Human Nutrition (2008-2009)