Katherine Wert, Ph.D. Titles and Appointments Assistant Professor Schools Medical School | Graduate School Departments Ophthalmology | Molecular Biology Graduate Programs Genetics, Development and Disease, Neuroscience Education Graduate School Columbia Uni in the City of Ne (2009), Nutrition Graduate School Columbia Uni in the City of Ne (2011), Nutritional Sciences Graduate School Columbia Uni in the City of Ne (2013), Nutritional Sciences Research Interest Embryonic and induced pluripotent stem cells, retinal organoids Gene therapy and genome engineering Inherited retinal degenerations Metabolism and metabolic reprogramming Retinitis Pigmentosa Sexual dimorphism and sex hormone signaling Publications Featured Publications Disruption to TFEB signaling and autophagy in newly formed oligodendrocytes leads to aberrant generation of CNS myelin. Barbosa D, Bhambri A, Vasquez M, Zhang Y, Sanchez G, Wert KJ, Gounko NV, Ellisman MH, Sun LO, Proc Natl Acad Sci U S A 2026 Jun 123 24 e2528668123 Acute developmental exposure to doxycycline and sucrose alters retinal function in three commonly used mouse strains. Nettesheim ER, Yee T, Mortada R, Wert KJ, Exp Eye Res 2026 May 270 111091 Elevated PRDM13 Disrupts Photoreceptor Function and Survival in the Mammalian Retina. Nettesheim ER, Rowe AA, Yee T, Alshaikhsalama A, Cepica T, Dutt V, Virani SS, Wickersham G, Mahajan VB, Small KW, Wert KJ, Invest Ophthalmol Vis Sci 2025 Aug 66 11 38 A pathway to sight. Wert KJ, Elife 2025 May 14 Female sex hormones exacerbate retinal neurodegeneration. Rowe AA, Velasquez MJ, Aumeier JW, Reyes S, Yee T, Nettesheim ER, McDonald JG, Wert KJ, Sci Adv 2025 Apr 11 15 eadr6211 Sensory quiescence induces a cell-non-autonomous integrated stress response curbed by condensate formation of the ATF4 and XRP1 effectors. Shekhar S, Tracy C, Lidsky PV, Andino R, Wert KJ, Krämer H, Nat Commun 2025 Jan 16 1 252 Female sex hormones exacerbate retinal neurodegeneration. Rowe AA, Reyes S, Velasquez MJ, Yee T, Nettesheim ER, McDonald JG, Wert KJ, bioRxiv 2024 Jul Murine Orchiectomy and Ovariectomy to Reduce Sex Hormone Production. Rowe AA, Issioui Y, Johnny B, Wert KJ, J Vis Exp 2023 Nov 201 Visual impairment cell non-autonomously dysregulates brain-wide proteostasis. Shekhar S, Wert KJ, Krämer H, bioRxiv 2023 Oct Human retina-in-a-dish: Unlocking the potential to study mechanisms of inherited retinal disease. Yee T, Wert KJ, Mol Ther Methods Clin Dev 2023 Sep 30 573-575 Results 1-10 of 41 1 2 3 4 5 Next Last Professional Associations/Affiliations Columbia University College of Physicians and Surgeons/Institute of Human Nutrition (2008-2009) Columbia University Graduate School of the Arts and Sciences/Institute of Human Nutrition (2009-2013) Stanford University School of Medicine (2017-2019) Whitehead Institute for Biomedical Research/MIT (2014-2017)
