Katherine Wert, Ph.D. Titles and Appointments Assistant Professor School Graduate School Department Ophthalmology | Molecular Biology Graduate Programs Genetics, Development and Disease, Neuroscience Education Graduate School Columbia Uni in the City of Ne (2009), Nutrition Graduate School Columbia Uni in the City of Ne (2011), Nutritional Sciences Graduate School Columbia Uni in the City of Ne (2013), Nutritional Sciences Research Interest Embryonic and induced pluripotent stem cells, retinal organoids Gene therapy and genome engineering Inherited retinal degenerations Metabolism and metabolic reprogramming Retinitis Pigmentosa Sexual dimorphism and sex hormone signaling Publications Sensory quiescence induces a cell-non-autonomous integrated stress response curbed by condensate formation of the ATF4 and XRP1 effectors Shekhar S, Tracy C, Lidsky PV, Andino R, Wert KJ, Krämer H Nature communications 2025 Dec 16 Elevated PRDM13 Disrupts Photoreceptor Function and Survival in the Mammalian Retina Nettesheim ER, Rowe AA, Yee T, Alshaikhsalama A, Cepica T, Dutt V, Virani SS, Wickersham G, Mahajan VB, Small KW, Wert KJ Investigative Ophthalmology and Visual Science 2025 Aug 66 Female sex hormones exacerbate retinal neurodegeneration Rowe AA, Velasquez MJ, Aumeier JW, Reyes S, Yee T, Nettesheim ER, McDonald JG, Wert KJ Science Advances 2025 Apr 11 Murine Orchiectomy and Ovariectomy to Reduce Sex Hormone Production Rowe AA, Issioui Y, Johnny B, Wert KJ Journal of Visualized Experiments 2023 Nov 2023 Human retina-in-a-dish: Unlocking the potential to study mechanisms of inherited retinal disease Yee T, Wert KJ Molecular Therapy Methods and Clinical Development 2023 Sep 30 573-575 HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy Kong Y, Liu PK, Li Y, Nolan ND, Quinn PM, Hsu CW, Jenny LA, Zhao J, Cui X, Chang YJ, Wert KJ, Sparrow JR, Wang NK, Tsang SH EMBO Molecular Medicine 2023 Feb 15 Long-term progression of retinal degeneration in a preclinical model of CLN7 Batten disease as a baseline for testing clinical therapeutics Rowe AA, Chen X, Nettesheim ER, Issioui Y, Dong T, Hu Y, Messahel S, Kayani SN, Gray SJ, Wert KJ EBioMedicine 2022 Nov 85 Base and Prime Editing in the Retina—From Preclinical Research toward Human Clinical Trials Yee T, Wert KJ International journal of molecular sciences 2022 Oct 23 Differential effects of obstructive sleep apnea on the corneal subbasal nerve plexus and retinal nerve fiber layer Bussan KA, Stuard WL, Mussi N, Lee W, Whitson JT, Issioui Y, Rowe AA, Wert KJ, Robertson DM PloS one 2022 Jun 17 Replenishment of TCA cycle intermediates provides photoreceptor resilience against neurodegeneration during progression of retinitis pigmentosa Rowe AA, Patel PD, Gordillo R, Wert KJ JCI Insight 2021 Sep 6 Results 1-10 of 35 1 2 3 4 Next Last Professional Associations/Affiliations Columbia University College of Physicians and Surgeons/Institute of Human Nutrition (2008-2009) Columbia University Graduate School of the Arts and Sciences/Institute of Human Nutrition (2009-2013) Stanford University School of Medicine (2017-2019) Whitehead Institute for Biomedical Research/MIT (2014-2017)
