Yoon Jung Kim, Ph.D. - Faculty Profile

Biography

Yoon Jung Kim, Ph.D., earned her bachelor's degree in environmental engineering from Ewha Woman’s University in Seoul and stayed to complete her master's in environmental microbiology. From there, she pursued a Ph.D. in chemical and biomolecular engineering from the Korean Advanced Institute of Science and Technology in Daejeon. Then she completed a postdoctoral fellowship in genetics at Yale University School of Medicine, where she studied transcriptional mechanisms modulated by enhancer and chromosome structure in cell development and disease. As a research scientist, she continued to work on gene regulation, establishing multiple genomic techniques.

Dr. Kim joined Children’s Medical Center Research Institute at UT Southwestern (CRI) in 2019 as a research scientist focused on genomics and gene regulation by phase-separate condensate formation and cell-specific enhancers. In 2023, she was promoted to Assistant Professor of Research in CRI. She also helps support CRI's Sequencing Shared Facility.

Publications

Featured Publications

Acquired Cross-resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC paralogs.: Pal Choudhuri S, Girard L, Lim JYS, Wise JF, Freitas B, Yang D, Wong E, Hamilton S, Chien VD, Kim YJ, Gilbreath C, Zhong J, Phat S, Myers DT, Christensen CL, Mazloom-Farsibaf H, Stanzione M, Wong KK, Hung YP, Farago AF, Meador CB, Dyson NJ, Lawrence MS, Wu S, Drapkin BJ, Cancer Discov 2024 Feb
Structural variation cooperates with permissive chromatin to control enhancer hijacking-mediated oncogenic transcription.: Botten GA, Zhang Y, Dudnyk K, Kim YJ, Liu X, Sanders JT, Imanci A, Droin N, Cao H, Kaphle P, Dickerson KE, Kumar KR, Chen M, Chen W, Solary E, Ly P, Zhou J, Xu J, Blood 2023 Jul 142 4 336-351
Light-activated macromolecular phase separation modulates transcription by reconfiguring chromatin interactions.: Kim YJ, Lee M, Lee YT, Jing J, Sanders JT, Botten GA, He L, Lyu J, Zhang Y, Mettlen M, Ly P, Zhou Y, Xu J, Sci Adv 2023 Mar 9 13 eadg1123
Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance.: Lyu J, Liu Y, Gong L, Chen M, Madanat YF, Zhang Y, Cai F, Gu Z, Cao H, Kaphle P, Kim YJ, Kalkan FN, Stephens H, Dickerson KE, Ni M, Chen W, Patel P, Mims AS, Borate U, Burd A, Cai SF, Yin CC, You MJ, Chung SS, Collins RH, DeBerardinis RJ, Liu X, Xu J, Cancer Discov 2023 Jan 13 1 170-193
A unified model of human hemoglobin switching through single-cell genome editing.: Shen Y, Verboon JM, Zhang Y, Liu N, Kim YJ, Marglous S, Nandakumar SK, Voit RA, Fiorini C, Ejaz A, Basak A, Orkin SH, Xu J, Sankaran VG, Nat Commun 2021 Aug 12 1 4991
The S-phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1/Hippo signaling pathway.: Hao Q, Zong X, Sun Q, Lin YC, Song YJ, Hashemikhabir S, Hsu RY, Kamran M, Chaudhary R, Tripathi V, Singh DK, Chakraborty A, Li XL, Kim YJ, Orjalo AV, Polycarpou-Schwarz M, Moriarity BS, Jenkins LM, Johansson HE, Zhu YJ, Diederichs S, Bagchi A, Kim TH, Janga SC, Lal A, Prasanth SG, Prasanth KV, Elife 2020 Oct 9
Global transcriptional activity dynamics reveal functional enhancer RNAs.: Kim YJ, Xie P, Cao L, Zhang MQ, Kim TH Genome Res. 2018 Oct
Long genes linked to autism spectrum disorders harbor broad enhancer-like chromatin domains.: Zhao YT, Kwon DY, Johnson BS, Fasolino M, Lamonica JM, Kim YJ, Zhao BS, He C, Vahedi G, Kim TH, Zhou Z Genome Res. 2018 May
Biotin tagging of MeCP2 in mice reveals contextual insights into the Rett syndrome transcriptome.: Johnson BS, Zhao YT, Fasolino M, Lamonica JM, Kim YJ, Georgakilas G, Wood KH, Bu D, Cui Y, Goffin D, Vahedi G, Kim TH, Zhou Z Nat. Med. 2017 Sep
Chromosome Conformation Capture for Research on Innate Antiviral Immunity.: Kim YJ, Kim TH, Methods Mol Biol 2017 1656 195-208

Professional Associations/Affiliations

Children's Medical Center Research Institute at UT Southwestern