Venuprasad Poojary, Ph.D.

Venuprasad Poojary, Ph.D., is an Associate Professor in the Departments of Internal Medicine and Immunology at UT Southwestern Medical Center and a member of the Division of Digestive and Liver Diseases.

Originally from Mangalore, India, Dr. Poojary holds a bachelor's degree in biochemistry and a master's degree in bioscience from Mangalore University. He earned his doctoral degree in immunology at the National Center for Cell Science in Kolkata, India. He was a postdoctoral fellow in immunology and cell signaling at the La Jolla Institute for Allergy and Immunology in San Diego, California.

Dr. Poojary joined the UT Southwestern faculty in 2019.

Dr. Poojary is a member of the American Association of Immunologists, the American Association for Cancer Research, the American Society of Cell Biology, and the American Association for the Advancement of Science.

• Colon Cancer
• Gut Microbiota
• Inflammasome
• Inflammatory Bowel Diseases (IBDs)
• Th17/Treg Differentiation

Featured Publications

The synthetic small molecule FL3 combats intestinal tumorigenesis via Axin1-mediated inhibition of Wnt/beta-catenin signaling.

Jackson DN, Alula KM, Delgado-Deida Y, Tabti R, Turner K, Wang X, Venuprasad K, Souza RF, Désaubry L, Theiss AL, Cancer Res. 2020 Jul

Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation.

Mukherjee S, Kumar R, Tsakem Lenou E, Basrur V, Kontoyiannis DL, Ioakeimidis F, Mosialos G, Theiss AL, Flavell RA, Venuprasad K, Nat. Immunol. 2020 Jun 21 6 626-635

Gut Microbiota Contributes to Spontaneous Colitis in E3 Ligase Itch-Deficient Mice.

Kathania M, Tsakem EL, Theiss AL, Venuprasad K, J. Immunol. 2020 Apr 204 8 2277-2284

Mitochondrial dysfunction during loss of prohibitin 1 triggers Paneth cell defects and ileitis.

Jackson DN, Panopoulos M, Neumann WL, Turner K, Cantarel BL, Thompson-Snipes L, Dassopoulos T, Feagins LA, Souza RF, Mills JC, Blumberg RS, Venuprasad K, Thompson WE, Theiss AL, Gut 2020 Feb

SUMOylation of ROR-?t inhibits IL-17 expression and inflammation via HDAC2.

Singh AK, Khare P, Obaid A, Conlon KP, Basrur V, DePinho RA, Venuprasad K, Nat Commun 2018 10 9 1 4515

IL-17-driven intestinal fibrosis is inhibited by Itch-mediated ubiquitination of HIC-5.

Paul J, Singh AK, Kathania M, Elviche TL, Zeng M, Basrur V, Theiss AL, Venuprasad K, Mucosal Immunol 2018 03 11 2 427-436

Elevated d-2-hydroxyglutarate during colitis drives progression to colorectal cancer.

Han J, Jackson D, Holm J, Turner K, Ashcraft P, Wang X, Cook B, Arning E, Genta RM, Venuprasad K, Souza RF, Sweetman L, Theiss AL Proc. Natl. Acad. Sci. U.S.A. 2018 Jan 115 5 1057-1062

Itch inhibits IL-17-mediated colon inflammation and tumorigenesis by ROR-?t ubiquitination.

Kathania M, Khare P, Zeng M, Cantarel B, Zhang H, Ueno H, Venuprasad K Nat. Immunol. 2016 Jun

The E3 ubiquitin ligase Itch inhibits p38a signaling and skin inflammation through the ubiquitylation of Tab1.

Theivanthiran B, Kathania M, Zeng M, Anguiano E, Basrur V, Vandergriff T, Pascual V, Wei WZ, Massoumi R, Venuprasad K Sci Signal 2015 Feb 8 365 ra22

The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation.

Ahmed N, Zeng M, Sinha I, Polin L, Wei WZ, Rathinam C, Flavell R, Massoumi R, Venuprasad K, Nat. Immunol. 2011 Nov 12 12 1176-83

 Featured Books

Immune regulation by ubiquitin conjugation. In Lymphocyte Signal Transduction

Venuprasad K, Yang C, Shao Y, Demydenko D, Harada Y, Jeon MS, Liu YC. (2008). Springer Link

Cbl-b-mediated regulation of cell signaling and cancer. In Signaling Pathways in Immune Cells

Venuprasad K. (2011). Springer Link

• American Association for Advancement of Science (2009)
• American Association for Cancer Research (2009)
• American Society of Cell Biology (2009)
• American Association of Immunologists (2006)