Biography

Venuprasad K. Poojary, Ph.D., a faculty member in Internal Medicine and Immunology, studies regulatory mechanisms in immune cells that prevent chronic inflammation. Dr. Poojary got his postdoctoral training at La Jolla Institute for Allergy and Immunology in San Diego, CA. His current research interests include post-translational modifications, immune tolerance, and T cell differentiation in regulation of gastrointestinal inflammation and cancer. The goal of his research is to identify key immune checkpoints of gastrointestinal disorders that could be targeted for therapeutic intervention and drug development.

Research Interest

  • Colon Cancer
  • Gut Microbiota
  • Inflammasome
  • Inflammatory Bowel Diseases (IBDs)
  • Th17/Treg Differentiation

Publications

Featured Publications LegendFeatured Publications

The synthetic small molecule FL3 combats intestinal tumorigenesis via Axin1-mediated inhibition of Wnt/beta-catenin signaling.
Jackson DN, Alula KM, Delgado-Deida Y, Tabti R, Turner K, Wang X, Venuprasad K, Souza RF, D├ęsaubry L, Theiss AL, Cancer Res. 2020 Jul
Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation.
Mukherjee S, Kumar R, Tsakem Lenou E, Basrur V, Kontoyiannis DL, Ioakeimidis F, Mosialos G, Theiss AL, Flavell RA, Venuprasad K, Nat. Immunol. 2020 Jun 21 6 626-635
Gut Microbiota Contributes to Spontaneous Colitis in E3 Ligase Itch-Deficient Mice.
Kathania M, Tsakem EL, Theiss AL, Venuprasad K, J. Immunol. 2020 Apr 204 8 2277-2284
Mitochondrial dysfunction during loss of prohibitin 1 triggers Paneth cell defects and ileitis.
Jackson DN, Panopoulos M, Neumann WL, Turner K, Cantarel BL, Thompson-Snipes L, Dassopoulos T, Feagins LA, Souza RF, Mills JC, Blumberg RS, Venuprasad K, Thompson WE, Theiss AL, Gut 2020 Feb
SUMOylation of ROR-?t inhibits IL-17 expression and inflammation via HDAC2.
Singh AK, Khare P, Obaid A, Conlon KP, Basrur V, DePinho RA, Venuprasad K, Nat Commun 2018 10 9 1 4515
IL-17-driven intestinal fibrosis is inhibited by Itch-mediated ubiquitination of HIC-5.
Paul J, Singh AK, Kathania M, Elviche TL, Zeng M, Basrur V, Theiss AL, Venuprasad K, Mucosal Immunol 2018 03 11 2 427-436
Elevated d-2-hydroxyglutarate during colitis drives progression to colorectal cancer.
Han J, Jackson D, Holm J, Turner K, Ashcraft P, Wang X, Cook B, Arning E, Genta RM, Venuprasad K, Souza RF, Sweetman L, Theiss AL Proc. Natl. Acad. Sci. U.S.A. 2018 Jan 115 5 1057-1062
Itch inhibits IL-17-mediated colon inflammation and tumorigenesis by ROR-?t ubiquitination.
Kathania M, Khare P, Zeng M, Cantarel B, Zhang H, Ueno H, Venuprasad K Nat. Immunol. 2016 Jun
The E3 ubiquitin ligase Itch inhibits p38a signaling and skin inflammation through the ubiquitylation of Tab1.
Theivanthiran B, Kathania M, Zeng M, Anguiano E, Basrur V, Vandergriff T, Pascual V, Wei WZ, Massoumi R, Venuprasad K Sci Signal 2015 Feb 8 365 ra22
The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation.
Ahmed N, Zeng M, Sinha I, Polin L, Wei WZ, Rathinam C, Flavell R, Massoumi R, Venuprasad K, Nat. Immunol. 2011 Nov 12 12 1176-83

Books

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Professional Associations/Affiliations

  • American Association for Advancement of Science (2009)
  • American Association for Cancer Research (2009)
  • American Society of Cell Biology (2009)
  • American Association of Immunologists (2006)