Eleanor Lederer, M.D. Professor Endowed Title John S. Fordtran, M.D. Professorship in Calcium Research School Medical School Department Internal Medicine | Charles and Jane Pak Center for Mineral Metabolism and Clinical Research You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Eleanor Lederer, M.D., is a Professor of Internal Medicine at UT Southwestern Medical Center, and a member of its Division of Nephrology. She specializes in chronic kidney disease complications, kidney stones, and kidney transplants. Dr. Lederer holds a bachelor’s degree in biology from Rice University in Houston. She earned her medical degree at Baylor College of Medicine, where she also completed her residency in internal medicine and fellowship in nephrology. She served as Chief Medical Resident at the Ben Taub General Hospital, co-director of the kidney transplant program and the Medical Director of the Pancreas Transplant Program at the Methodist Hospital. She joined the faculty at the University of Louisville in 1991, where she developed an independent research program in the study of phosphate transport in the proximal tubule. She served as Division Chief of Nephrology and Hypertension, Interim Associate Dean of Research for the University of Louisville School of Medicine, and Interim Chair of Medicine. She was a Merit Review-funded investigator at the affiliated Robley Rex VA Medical Center where she also served as Interim Chief of Medical Services and Associate Chief of Staff. She joined the UT Southwestern faculty in 2020. Dr. Lederer is the John S. Fordtran Endowed Professor in Calcium Research at UTSW’s Charles and Jane Pak Center for Mineral Metabolism. In addition, she serves as the Assistant Chief of Medical Services for Research and Co-Director of the Network of Dedicated Enrollment Sites (NODES) program at the affiliated VA North Texas Health Sciences Center. Dr. Lederer is currently funded through the U.S. Department of Veterans Affairs to study the regulation of parathyroid hormone, phosphate, and calcium in chronic kidney disease. She has published a number of peer-reviewed articles and has authored or coauthored chapters in numerous books, including Essentials of Chronic Kidney Disease and Principles of Geriatric Medicine and Gerontology. She is an active member of several professional organizations, including the Renal Physicians Association, the American College of Physicians, the International Society of Nephrology, the American Association for the Advancement of Science, and the American Society of Nephrology, which she served as a member of the on the Executive Committee of the Training Program Directors, the Publications Committee, and ultimately, as president. Among many other honors, in 2020 Dr. Lederer received the Excellence in Patient Care Award from the National Kidney Foundation of Kentucky, and in 2022, she was selected to deliver the Jack W. Coburn, M.D., Endowed Lecturship. Education Medical School Baylor College of Medicine (1978) Internship Baylor College of Medicine (1979) Residency Baylor College of Medicine (1981), Internal Medicine Chief Resident Baylor College of Medicine (1983), Internal Medicine Fellowship Baylor College of Medicine (1984), Nephrology Research Interest Epithelial Transport Nephrolithiasis Phosphate Homeostasis Publications Featured Publications Phosphate Transport in Epithelial and Nonepithelial Tissue. Hernando N, Gagnon KB, Lederer ED, Physiol. Rev. 2020 Apr Sodium-hydrogen exchanger regulatory factor-1 (NHERF1) confers salt sensitivity in both male and female models of hypertension in aging. Pushpakumar S, Ahmad A, Ketchem CJ, Jose PA, Weinman EJ, Sen U, Lederer ED, Khundmiri SJ, Life Sci. 2020 Feb 243 117226 Loss of the Na+/H+ Exchange Regulatory Factor 1 Increases Susceptibility to Cisplatin-Induced Acute Kidney Injury. Bushau-Sprinkle A, Barati M, Conklin C, Dupre T, Gagnon KB, Khundmiri SJ, Clark B, Siskind L, Doll MA, Rane M, Brier M, Coventry S, Lederer ED, Am. J. Pathol. 2019 Jun 189 6 1190-1200 Loss of NHERF-1 expression prevents dopamine-mediated Na-K-ATPase regulation in renal proximal tubule cells from rat models of hypertension: aged F344 rats and spontaneously hypertensive rats. Barati MT, Ketchem CJ, Merchant ML, Kusiak WB, Jose PA, Weinman EJ, LeBlanc AJ, Lederer ED, Khundmiri SJ, Am. J. Physiol., Cell Physiol. 2017 Aug 313 2 C197-C206 Identification of an RNA-binding protein that is phosphorylated by PTH and potentially mediates PTH-induced destabilization of Npt2a mRNA. Murray RD, Merchant ML, Hardin E, Clark B, Khundmiri SJ, Lederer ED, Am. J. Physiol., Cell Physiol. 2016 Feb 310 3 C205-15 Protein-DNA Interactions at the Opossum Npt2a Promoter are Dependent upon NHERF-1. Clark BJ, Murray RD, Salyer SA, Tyagi SC, Arumugam C, Khundmiri SJ, Lederer ED, Cell. Physiol. Biochem. 2016 39 1 1-12 Role of Na+/H+ exchanger regulatory factor 1 in forward trafficking of the type IIa Na+-Pi cotransporter. Ketchem CJ, Khundmiri SJ, Gaweda AE, Murray R, Clark BJ, Weinman EJ, Lederer ED, Am. J. Physiol. Renal Physiol. 2015 Jul 309 2 F109-19 Role of vacuolar ATPase in the trafficking of renal type IIa sodium-phosphate cotransporter. Ahmad A, Khundmiri SJ, Pribble F, Merchant ML, Ameen M, Klein JB, Levi M, Lederer ED, Cell. Physiol. Biochem. 2011 27 6 703-14 Proteomic analysis of renal calculi indicates an important role for inflammatory processes in calcium stone formation. Merchant ML, Cummins TD, Wilkey DW, Salyer SA, Powell DW, Klein JB, Lederer ED, Am. J. Physiol. Renal Physiol. 2008 Oct 295 4 F1254-8 Novel regulatory function for NHERF-1 in Npt2a transcription. Khundmiri SJ, Ahmad A, Bennett RE, Weinman EJ, Steplock D, Cole J, Baumann PD, Lewis J, Singh S, Clark BJ, Lederer ED, Am. J. Physiol. Renal Physiol. 2008 Apr 294 4 F840-9 Results 1-10 of 12 1 2 Next Last Books Featured Books Introduction and General Principles. In Essentials of Chronic Kidney Disease, 2nd Ed. Lederer ED (2018). Disorders of Fluid and Electrolyte Balance. In Principles of Geriatric Medicine and Gerontology, 7th Ed. Lederer E, Nayak V (2017). Renal Transport of Calcium, Magnesium, and Phosphate. In Brenner & Rector's The Kidney, 6th Ed. Suki WN, Lederer ED, Rose D (2000). Philadelphia, PA, W.B. Saunders Hyperphosphatemia and Hypophosphatemia. In Primer on the Metabolic Bone Diseases and Disorder of Mineral Metabolism, 5th Ed. Hruska KA, Lederer ED (2003). Washington, D.C., American Society for Bone and Mineral Research Severe Electrolyte Distrubances. In Principles of Critical Care, 2nd Ed. Hammes M, Brennan S, Lederer ED (1997). McGraw-Hill Inc. Hyperphosphatemia. In Medscape Reference Lederer E, Ouseph R, Nayak V (2020). Transplantation Complications. In Kidney Transplantation Toledo-Pereyra L, Lederer ED, Suki WN (1988). F.A. Davis Clinical course and care of the post-transplant patient. In Kidney Transplantation Lederer ED, Suki WN (1988). F.A. Davis Co Transplantation in systemic, inherited and metabolic disorders. In Therapy of Renal Disease and Related Disorders Lederer ED, Suki WN (1991). Kluwer, Inc Severe electrolyte disturbances. In Principles of Critical Care Brennan TS, Lederer ED (1992). McGraw Hill Inc Dialysis in the critical care patient. In Principles of Critical Care Lederer ED, Gillum DM (1992). McGraw-Hill, Inc Severe Electrolyte Disturbances. In Principles of Critical Care, 2nd ed Hammes M, Brennan S, Lederer ED (1997). McGraw-Hill Inc Dialysis in the Critical Care Patient. In Principles of Critical Care, 2nd ed Chen MS, Lederer ED, Gillum DM (197). McGraw-Hill Inc Pregnancy in Transplant Recipients. In Transplantation: A Primer Lederer ED (1997). Acute renal failure. In Critical Care Pearls Lederer ED. (1997). Philadelphia, Pa, Hanley and Belfus Urinary tract infection. In Primary Care in Obstetrics and Gynecology Lederer ED (1997). New York, Springer-Verlag Transplantation in systemic inherited and metabolic disorders. In Therapy of Renal Disease and Related Disorders Lederer ED (1997). Kluwer, Inc. Hyperphosphatemia and Hypophosphatemia. In Primer on the Metabolic Bone Diseases and Disorder of Mineral Metabolism Hruska KA, Lederer ED (1999). Philadelphia, Pa, Lippincott Williams & Wilkins Renal Transport of Calcium, Magnesium, and Phosphate. In Brenner & Rector?s The Kidney, 6th ed Suki WN, Lederer ED (2000). Philadelphia, Pa, W.B. Saunders Hyperphosphatemia. In eMedicine Textbook of Medicine, OB/GYN, Psychiatry, and Surgery Lederer ED, Ouseph R, Erbeck K (2002). Hypophosphatemia. In eMedicine Textbook of Medicine, OB/GYN, Psychiatry, and Surgery Lederer ED, Ouseph R, Erbeck K (2002). Hyperkalemia. In eMedicine Textbook of Medicine, OB/GYN, Psychiatry, and Surgery Lederer ED, Ouseph R, Erbeck K (2002). Hypokalemia. In eMedicine Textbook of Medicine, OB/GYN, Psychiatry, and Surgery Lederer ED, Erbeck K, Ouseph R. (2002). Hyperphosphatemia and Hypophosphatemia. In Primer on the Metabolic Bone Diseases and Disorder of Mineral Metabolism, 5th ed. Hruska KA, Lederer ED (2003). Washington, DC, American Society for Bone and Mineral Research Hyperphosphatemia. In eMedicine Textbook of Medicine, OB/GYN, Psychiatry, and Surgery Lederer ED, Ouseph R, Dailey A, Hill S. (2006). Hypophosphatemia. In eMedicine Textbook of Adult Medicine Lederer ED, Ouseph R, Mittal D, Deo D. (2007). WebMD Hyperkalemia. In eMedicine Textbook of Adult Medicin Lederer ED, Ouseph R, Nayak V, Dinh S (2007). WebMD Hypokalemia. In eMedicine Textbook of Adult Medicine Lederer ED, Ouseph R, Yazel L (2007). WebMD Lithium Nephropathy. In eMedicine Textbook of Adult Medicin Lederer ED, Dacso C, Tran M (2007). WebMD Hypokalemia. In eMedicine Lederer E, Ouseph R, Ford L (2009). WebMD Hyperphosphatemia. In eMedicine Lederer E, Ouseph R, Nayak V (2009). WebMD Hypophosphatemia. In eMedicine Lederer E, Ouseph R, Patel S (2009). WebMD Lithium Nephropathy. In eMedicine Lederer E, Dacso CC, Tran MD (2009). WebMD Pharmacologic Treatment of Hypertension. In Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation Vasavada N, Lederer E (2012). Lifestyle Modifications in the Treatment of Hypertension. In Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation Nayak N, Caster, D, Lederer E (2012). Hypertensive Emergencies and Resistant Hypertension. In Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation Mackelaite L, Lederer E (2012). Springer Secondary Hypertension. In Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation Lederer E (2012). Springer Primary Hypertension. In Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation Lederer E (2012). Springer Classification of Hypertension. In Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation Burtnett W, Lederer E (2012). Springer Hyperkalemia. In Medscape Reference Lederer E, Alsauskas ZC, Mackelaite L, Nayak V (2013). Hypokalemia. In Medscape Reference Lederer E, Alsauskas ZC, Mackelaite L, Nayak V (2013). The Role of Vacuolar ATPase in the Regulation of Npt2a Trafficking.. In Handbook of H+-ATPases Lederer E and Khundmiri SJ (2014). Stanford Honors & Awards Jack W. Coburn, M.D., Endowed LectureshipAmerican Society of Nephrology (2022) CouncilorSouthern Society for Clinical Investigation (2021) Excellence in Patient Care AwardNational Kidney Foundation of Kentucky (2020) Top Doctor in NephrologyCastle Connolly (2020) Excellence in LeadershipRobley Rex VA Medical Center (2019) Top Doctor Louisville (2019) Internal Medicine Resident Teaching AwardUniversity of Louisville (2018) Top Doctor Louisville (2017) Hans Ussing LectureshipAmerican Physiological Society (2014) Top Doctor Louisville (2014) Distinguished Teacher AwardUniversity of Louisville (2009) Internal Medicine Resident Teaching AwardUniversity of Louisville (2009-2010) Internal Medicine Resident Teaching AwardUniversity of Louisville (2006) Internal Medicine Resident Teaching AwardUniversity of Louisville (2003-2004) Phi Beta KappaScholastic Honor Society (1974) Professional Associations/Affiliations American Association for the Advancement of Science American College of Physicians American Heart Association's Council on the Kidney in Cardiovascular Disease American Physiological Society American Society for Bone and Mineral Research American Society of Nephrology International Society of Nephrology National Kidney Foundation Renal Physicians Association
