Eleanor Lederer, M.D.
Professor

Dr. Lederer received her medical training in Houston, Tx, at Baylor College of Medicine, including medical school, internal medicine residency, and nephrology fellowship training. She served as Chief Medical Resident at the Ben Taub General Hospital, co-director of the kidney transplant program and the Medical Director of the Pancreas Transplant Program at the Methodist Hospital. She moved to the University of Louisville in 1991 where she developed an independent research program in the study of phosphate transport in the proximal tubule. She served as Division Chief of Nephrology and Hypertension, Interim Associate Dean of Research for the University of Louisville School of Medicine, and Interim Chair of Medicine. She was a Merit Review-funded investigator at the affiliated Robley Rex VA Medical Center where she also served as Interim Chief of Medical Services and Associate Chief of Staff. She has been very active in the American Society of Nephrology where she served on the Executive Committee of the Training Program Directors, the Publications Committee, and the Council, ultimately serving as President of ASN in 2017.

Dr. Lederer moved to the University of Texas Southwestern, motivated by the strong Division of Nephrology, the commitment to all aspects of the academic mission, and the strength of its Mineral Metabolism Center. She is currently funded through the VA to study the regulation of PTH, phosphate, and calcium in chronic kidney disease and is an active clinician with expertise in general nephrology, renal physiology, nephrolithiasis, genetic kidney disease, and kidney transplantation.

Medical School

Baylor College of Medicine (1978)

Internship

Baylor College of Medicine (1979)

Residency

Baylor College of Medicine (1981), Internal Medicine

Chief Resident

Baylor College of Medicine (1983), Internal Medicine

Fellowship

Baylor College of Medicine (1984), Nephrology

• Epithelial Transport
• Nephrolithiasis
• Phosphate Homeostasis

Featured Publications

Phosphate Transport in Epithelial and Nonepithelial Tissue.

Hernando N, Gagnon KB, Lederer ED, Physiol. Rev. 2020 Apr

Sodium-hydrogen exchanger regulatory factor-1 (NHERF1) confers salt sensitivity in both male and female models of hypertension in aging.

Pushpakumar S, Ahmad A, Ketchem CJ, Jose PA, Weinman EJ, Sen U, Lederer ED, Khundmiri SJ, Life Sci. 2020 Feb 243 117226

Loss of the Na⁺/H⁺ Exchange Regulatory Factor 1 Increases Susceptibility to Cisplatin-Induced Acute Kidney Injury.

Bushau-Sprinkle A, Barati M, Conklin C, Dupre T, Gagnon KB, Khundmiri SJ, Clark B, Siskind L, Doll MA, Rane M, Brier M, Coventry S, Lederer ED, Am. J. Pathol. 2019 Jun 189 6 1190-1200

Loss of NHERF-1 expression prevents dopamine-mediated Na-K-ATPase regulation in renal proximal tubule cells from rat models of hypertension: aged F344 rats and spontaneously hypertensive rats.

Barati MT, Ketchem CJ, Merchant ML, Kusiak WB, Jose PA, Weinman EJ, LeBlanc AJ, Lederer ED, Khundmiri SJ, Am. J. Physiol., Cell Physiol. 2017 Aug 313 2 C197-C206

Identification of an RNA-binding protein that is phosphorylated by PTH and potentially mediates PTH-induced destabilization of Npt2a mRNA.

Murray RD, Merchant ML, Hardin E, Clark B, Khundmiri SJ, Lederer ED, Am. J. Physiol., Cell Physiol. 2016 Feb 310 3 C205-15

Protein-DNA Interactions at the Opossum Npt2a Promoter are Dependent upon NHERF-1.

Clark BJ, Murray RD, Salyer SA, Tyagi SC, Arumugam C, Khundmiri SJ, Lederer ED, Cell. Physiol. Biochem. 2016 39 1 1-12

Role of Na+/H+ exchanger regulatory factor 1 in forward trafficking of the type IIa Na+-Pi cotransporter.

Ketchem CJ, Khundmiri SJ, Gaweda AE, Murray R, Clark BJ, Weinman EJ, Lederer ED, Am. J. Physiol. Renal Physiol. 2015 Jul 309 2 F109-19

Proteomic analysis of renal calculi indicates an important role for inflammatory processes in calcium stone formation.

Merchant ML, Cummins TD, Wilkey DW, Salyer SA, Powell DW, Klein JB, Lederer ED, Am. J. Physiol. Renal Physiol. 2008 Oct 295 4 F1254-8

Novel regulatory function for NHERF-1 in Npt2a transcription.

Khundmiri SJ, Ahmad A, Bennett RE, Weinman EJ, Steplock D, Cole J, Baumann PD, Lewis J, Singh S, Clark BJ, Lederer ED, Am. J. Physiol. Renal Physiol. 2008 Apr 294 4 F840-9

Parathyroid hormone regulation of type II sodium-phosphate cotransporters is dependent on an A kinase anchoring protein.

Khundmiri SJ, Rane MJ, Lederer ED, J. Biol. Chem. 2003 Mar 278 12 10134-41

 Featured Books

Introduction and General Principles. In Essentials of Chronic Kidney Disease, 2nd Ed.

Lederer ED (2018).

Disorders of Fluid and Electrolyte Balance. In Principles of Geriatric Medicine and Gerontology, 7th Ed.

Lederer E, Nayak V (2017).

Renal Transport of Calcium, Magnesium, and Phosphate. In Brenner & Rector's The Kidney, 6th Ed.

Suki WN, Lederer ED, Rose D (2000). Philadelphia, PA, W.B. Saunders

Hyperphosphatemia and Hypophosphatemia. In Primer on the Metabolic Bone Diseases and Disorder of Mineral Metabolism, 5th Ed.

Hruska KA, Lederer ED (2003). Washington, D.C., American Society for Bone and Mineral Research

Severe Electrolyte Distrubances. In Principles of Critical Care, 2nd Ed.

Hammes M, Brennan S, Lederer ED (1997). McGraw-Hill Inc.

• Top Doctor Louisville
  (2019)
• Internal Medicine Resident Teaching Award
  University of Louisville (2018)
• Top Doctor Louisville
  (2017)
• Hans Ussing Lectureship
  American Physiological Society (2014)
• Top Doctor Louisville
  (2014)
• Distinguished Teacher Award
  University of Louisville (2009)
• Internal Medicine Resident Teaching Award
  University of Louisville (2009-2010)
• Internal Medicine Resident Teaching Award
  University of Louisville (2006)
• Internal Medicine Resident Teaching Award
  University of Louisville (2003-2004)
• Phi Beta Kappa
  Scholastic Honor Society (1974)