Eleanor Lederer, M.D.

Eleanor Lederer, M.D., is a Professor of Internal Medicine at UT Southwestern Medical Center, and a member of its Division of Nephrology. She specializes in chronic kidney disease complications, kidney stones, and kidney transplants.

Dr. Lederer holds a bachelor’s degree in biology from Rice University in Houston. She earned her medical degree at Baylor College of Medicine, where she also completed her residency in internal medicine and fellowship in nephrology.

She served as Chief Medical Resident at the Ben Taub General Hospital, co-director of the kidney transplant program and the Medical Director of the Pancreas Transplant Program at the Methodist Hospital. She joined the faculty at the University of Louisville in 1991, where she developed an independent research program in the study of phosphate transport in the proximal tubule. She served as Division Chief of Nephrology and Hypertension, Interim Associate Dean of Research for the University of Louisville School of Medicine, and Interim Chair of Medicine. She was a Merit Review-funded investigator at the affiliated Robley Rex VA Medical Center where she also served as Interim Chief of Medical Services and Associate Chief of Staff.

She joined the UT Southwestern faculty in 2020.

Dr. Lederer is the John S. Fordtran Endowed Professor in Calcium Research at UTSW’s Charles and Jane Pak Center for Mineral Metabolism. In addition, she serves as the Assistant Chief of Medical Services for Research and Co-Director of the Network of Dedicated Enrollment Sites (NODES) program at the affiliated VA North Texas Health Sciences Center.

Dr. Lederer is currently funded through the U.S. Department of Veterans Affairs to study the regulation of parathyroid hormone, phosphate, and calcium in chronic kidney disease. She has published a number of peer-reviewed articles and has authored or coauthored chapters in numerous books, including Essentials of Chronic Kidney Disease and Principles of Geriatric Medicine and Gerontology.

She is an active member of several professional organizations, including the Renal Physicians Association, the American College of Physicians, the International Society of Nephrology, the American Association for the Advancement of Science, and the American Society of Nephrology, which she served as a member of the on the Executive Committee of the Training Program Directors, the Publications Committee, and ultimately, as president.

Among many other honors, in 2020 Dr. Lederer received the Excellence in Patient Care Award from the National Kidney Foundation of Kentucky, and in 2022, she was selected to deliver the Jack W. Coburn, M.D., Endowed Lecturship.

Medical School

Baylor College of Medicine (1978)

Internship

Baylor College of Medicine (1979)

Residency

Baylor College of Medicine (1981), Internal Medicine

Chief Resident

Baylor College of Medicine (1983), Internal Medicine

Fellowship

Baylor College of Medicine (1984), Nephrology

• Epithelial Transport
• Nephrolithiasis
• Phosphate Homeostasis

Featured Publications

Phosphate Transport in Epithelial and Nonepithelial Tissue.

Hernando N, Gagnon KB, Lederer ED, Physiol. Rev. 2020 Apr

Sodium-hydrogen exchanger regulatory factor-1 (NHERF1) confers salt sensitivity in both male and female models of hypertension in aging.

Pushpakumar S, Ahmad A, Ketchem CJ, Jose PA, Weinman EJ, Sen U, Lederer ED, Khundmiri SJ, Life Sci. 2020 Feb 243 117226

Loss of the Na⁺/H⁺ Exchange Regulatory Factor 1 Increases Susceptibility to Cisplatin-Induced Acute Kidney Injury.

Bushau-Sprinkle A, Barati M, Conklin C, Dupre T, Gagnon KB, Khundmiri SJ, Clark B, Siskind L, Doll MA, Rane M, Brier M, Coventry S, Lederer ED, Am. J. Pathol. 2019 Jun 189 6 1190-1200

Loss of NHERF-1 expression prevents dopamine-mediated Na-K-ATPase regulation in renal proximal tubule cells from rat models of hypertension: aged F344 rats and spontaneously hypertensive rats.

Barati MT, Ketchem CJ, Merchant ML, Kusiak WB, Jose PA, Weinman EJ, LeBlanc AJ, Lederer ED, Khundmiri SJ, Am. J. Physiol., Cell Physiol. 2017 Aug 313 2 C197-C206

Identification of an RNA-binding protein that is phosphorylated by PTH and potentially mediates PTH-induced destabilization of Npt2a mRNA.

Murray RD, Merchant ML, Hardin E, Clark B, Khundmiri SJ, Lederer ED, Am. J. Physiol., Cell Physiol. 2016 Feb 310 3 C205-15

Protein-DNA Interactions at the Opossum Npt2a Promoter are Dependent upon NHERF-1.

Clark BJ, Murray RD, Salyer SA, Tyagi SC, Arumugam C, Khundmiri SJ, Lederer ED, Cell. Physiol. Biochem. 2016 39 1 1-12

Role of Na+/H+ exchanger regulatory factor 1 in forward trafficking of the type IIa Na+-Pi cotransporter.

Ketchem CJ, Khundmiri SJ, Gaweda AE, Murray R, Clark BJ, Weinman EJ, Lederer ED, Am. J. Physiol. Renal Physiol. 2015 Jul 309 2 F109-19

Role of vacuolar ATPase in the trafficking of renal type IIa sodium-phosphate cotransporter.

Ahmad A, Khundmiri SJ, Pribble F, Merchant ML, Ameen M, Klein JB, Levi M, Lederer ED, Cell. Physiol. Biochem. 2011 27 6 703-14

Proteomic analysis of renal calculi indicates an important role for inflammatory processes in calcium stone formation.

Merchant ML, Cummins TD, Wilkey DW, Salyer SA, Powell DW, Klein JB, Lederer ED, Am. J. Physiol. Renal Physiol. 2008 Oct 295 4 F1254-8

Novel regulatory function for NHERF-1 in Npt2a transcription.

Khundmiri SJ, Ahmad A, Bennett RE, Weinman EJ, Steplock D, Cole J, Baumann PD, Lewis J, Singh S, Clark BJ, Lederer ED, Am. J. Physiol. Renal Physiol. 2008 Apr 294 4 F840-9

 Featured Books

Introduction and General Principles. In Essentials of Chronic Kidney Disease, 2nd Ed.

Lederer ED (2018).

Disorders of Fluid and Electrolyte Balance. In Principles of Geriatric Medicine and Gerontology, 7th Ed.

Lederer E, Nayak V (2017).

Renal Transport of Calcium, Magnesium, and Phosphate. In Brenner & Rector's The Kidney, 6th Ed.

Suki WN, Lederer ED, Rose D (2000). Philadelphia, PA, W.B. Saunders

Hyperphosphatemia and Hypophosphatemia. In Primer on the Metabolic Bone Diseases and Disorder of Mineral Metabolism, 5th Ed.

Hruska KA, Lederer ED (2003). Washington, D.C., American Society for Bone and Mineral Research

Severe Electrolyte Distrubances. In Principles of Critical Care, 2nd Ed.

Hammes M, Brennan S, Lederer ED (1997). McGraw-Hill Inc.

Hyperphosphatemia. In Medscape Reference

Lederer E, Ouseph R, Nayak V (2020).

Transplantation Complications. In Kidney Transplantation

Toledo-Pereyra L, Lederer ED, Suki WN (1988). F.A. Davis

Clinical course and care of the post-transplant patient. In Kidney Transplantation

Lederer ED, Suki WN (1988). F.A. Davis Co

Transplantation in systemic, inherited and metabolic disorders. In Therapy of Renal Disease and Related Disorders

Lederer ED, Suki WN (1991). Kluwer, Inc

Severe electrolyte disturbances. In Principles of Critical Care

Brennan TS, Lederer ED (1992). McGraw Hill Inc

Dialysis in the critical care patient. In Principles of Critical Care

Lederer ED, Gillum DM (1992). McGraw-Hill, Inc

Severe Electrolyte Disturbances. In Principles of Critical Care, 2nd ed

Hammes M, Brennan S, Lederer ED (1997). McGraw-Hill Inc

Dialysis in the Critical Care Patient. In Principles of Critical Care, 2nd ed

Chen MS, Lederer ED, Gillum DM (197). McGraw-Hill Inc

Pregnancy in Transplant Recipients. In Transplantation: A Primer

Lederer ED (1997).

Acute renal failure. In Critical Care Pearls

Lederer ED. (1997). Philadelphia, Pa, Hanley and Belfus

Urinary tract infection. In Primary Care in Obstetrics and Gynecology

Lederer ED (1997). New York, Springer-Verlag

Transplantation in systemic inherited and metabolic disorders. In Therapy of Renal Disease and Related Disorders

Lederer ED (1997). Kluwer, Inc.

Hyperphosphatemia and Hypophosphatemia. In Primer on the Metabolic Bone Diseases and Disorder of Mineral Metabolism

Hruska KA, Lederer ED (1999). Philadelphia, Pa, Lippincott Williams & Wilkins

Renal Transport of Calcium, Magnesium, and Phosphate. In Brenner & Rector?s The Kidney, 6th ed

Suki WN, Lederer ED (2000). Philadelphia, Pa, W.B. Saunders

Hyperphosphatemia. In eMedicine Textbook of Medicine, OB/GYN, Psychiatry, and Surgery

Lederer ED, Ouseph R, Erbeck K (2002).

Hypophosphatemia. In eMedicine Textbook of Medicine, OB/GYN, Psychiatry, and Surgery

Lederer ED, Ouseph R, Erbeck K (2002).

Hyperkalemia. In eMedicine Textbook of Medicine, OB/GYN, Psychiatry, and Surgery

Lederer ED, Ouseph R, Erbeck K (2002).

Hypokalemia. In eMedicine Textbook of Medicine, OB/GYN, Psychiatry, and Surgery

Lederer ED, Erbeck K, Ouseph R. (2002).

Hyperphosphatemia and Hypophosphatemia. In Primer on the Metabolic Bone Diseases and Disorder of Mineral Metabolism, 5th ed.

Hruska KA, Lederer ED (2003). Washington, DC, American Society for Bone and Mineral Research

Hyperphosphatemia. In eMedicine Textbook of Medicine, OB/GYN, Psychiatry, and Surgery

Lederer ED, Ouseph R, Dailey A, Hill S. (2006).

Hypophosphatemia. In eMedicine Textbook of Adult Medicine

Lederer ED, Ouseph R, Mittal D, Deo D. (2007). WebMD

Hyperkalemia. In eMedicine Textbook of Adult Medicin

Lederer ED, Ouseph R, Nayak V, Dinh S (2007). WebMD

Hypokalemia. In eMedicine Textbook of Adult Medicine

Lederer ED, Ouseph R, Yazel L (2007). WebMD

Lithium Nephropathy. In eMedicine Textbook of Adult Medicin

Lederer ED, Dacso C, Tran M (2007). WebMD

Hypokalemia. In eMedicine

Lederer E, Ouseph R, Ford L (2009). WebMD

Hyperphosphatemia. In eMedicine

Lederer E, Ouseph R, Nayak V (2009). WebMD

Hypophosphatemia. In eMedicine

Lederer E, Ouseph R, Patel S (2009). WebMD

Lithium Nephropathy. In eMedicine

Lederer E, Dacso CC, Tran MD (2009). WebMD

Pharmacologic Treatment of Hypertension. In Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation

Vasavada N, Lederer E (2012).

Lifestyle Modifications in the Treatment of Hypertension. In Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation

Nayak N, Caster, D, Lederer E (2012).

Hypertensive Emergencies and Resistant Hypertension. In Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation

Mackelaite L, Lederer E (2012). Springer

Secondary Hypertension. In Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation

Lederer E (2012). Springer

Primary Hypertension. In Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation

Lederer E (2012). Springer

Classification of Hypertension. In Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation

Burtnett W, Lederer E (2012). Springer

Hyperkalemia. In Medscape Reference

Lederer E, Alsauskas ZC, Mackelaite L, Nayak V (2013).

Hypokalemia. In Medscape Reference

Lederer E, Alsauskas ZC, Mackelaite L, Nayak V (2013).

The Role of Vacuolar ATPase in the Regulation of Npt2a Trafficking.. In Handbook of H+-ATPases

Lederer E and Khundmiri SJ (2014). Stanford

• Jack W. Coburn, M.D., Endowed Lectureship
  American Society of Nephrology (2022)
• Councilor
  Southern Society for Clinical Investigation (2021)
• Excellence in Patient Care Award
  National Kidney Foundation of Kentucky (2020)
• Top Doctor in Nephrology
  Castle Connolly (2020)
• Excellence in Leadership
  Robley Rex VA Medical Center (2019)
• Top Doctor Louisville
  (2019)
• Internal Medicine Resident Teaching Award
  University of Louisville (2018)
• Top Doctor Louisville
  (2017)
• Hans Ussing Lectureship
  American Physiological Society (2014)
• Top Doctor Louisville
  (2014)
• Distinguished Teacher Award
  University of Louisville (2009)
• Internal Medicine Resident Teaching Award
  University of Louisville (2009-2010)
• Internal Medicine Resident Teaching Award
  University of Louisville (2006)
• Internal Medicine Resident Teaching Award
  University of Louisville (2003-2004)
• Phi Beta Kappa
  Scholastic Honor Society (1974)

• American Association for the Advancement of Science
• American College of Physicians
• American Heart Association's Council on the Kidney in Cardiovascular Disease
• American Physiological Society
• American Society for Bone and Mineral Research
• American Society of Nephrology
• International Society of Nephrology
• National Kidney Foundation
• Renal Physicians Association