Yazan Madanat, M.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center, and a member of its Division of Hematology and Oncology. His clinical research interest lies in understanding the molecular and genomic drivers of disease and to better understand ways to incorporate novel therapies for our patients.

Originally from Amman, Jordan, Dr. Madanat earned his medical degree at the University of Jordan. He completed his residency training in internal medicine at the Cleveland Clinic, in Cleveland, Ohio. Then, drawn by the opportunity for harmonious integration of clinical medicine, pathophysiology of disease and novel treatment approaches, he completed his hematology and medical oncology fellowship at the Cleveland Clinic with clinical and research focus on myeloid malignancies; myelodysplastic syndromes, myelodysplastic/myeloproliferative neoplasms (MDS/MPN) and acute myeloid leukemia.

Certified by the American Board of Internal Medicine, he joined the UT Southwestern faculty in 2019.

Dr. Madanat is a member of several professional organizations, including the American Society of Clinical Oncology, the American Society of Hematology, and the American College of Physicians. He earned Abstract Achievement Awards from the American Society of Hematology for two consecutive years (2017 and 2018) and received an honorable distinction award from the Society of Hematologic Oncology in 2018.  

He has delivered several presentations and published numerous academic articles and book chapters that focus on the treatment of myeloid malignancies, acute leukemia, and myelodysplastic syndromes.


Personal Note

Outside of medicine, Dr. Madanat's interests include swimming, cooking, and spending time with his family.


Medical School
University of Jordan Faculty of Medicine, Jordan (2011)
Al-Hussein Hospital, Jordan (2012), General Medicine & Surgery
King Hussein Cancer Center, Jordan (2013), Internal Medicine
Cleveland Clinic Foundation (2016), Internal Medicine
Cleveland Clinic Foundation (2019), Hematology Oncology

Research Interest

  • Incorporating novel therapies in the treatment paradigm of MDS
  • Uncovering differences in stem cell biology in MDS
  • Using genomic alterations to personalize therapy in MDS


Featured Publications LegendFeatured Publications

Advances in Acute Myeloid Leukemia Genomics, Where Do We Stand in 2018?
Madanat YF, Kalaycio ME, Nazha A, Acta Med Acad 2019 Apr 48 1 35-44
Wilms tumor 1 expression: addressing the 'elephant' in MDS.
Madanat YF, Sekeres MA, Leuk. Lymphoma 2019 Mar 60 3 566-567
Can allogeneic hematopoietic cell transplant cure therapy-related acute leukemia?
Madanat YF, Gerds AT, Best Pract Res Clin Haematol 2019 03 32 1 104-113
Long-Term Outcomes of Hairy Cell Leukemia Treated With Purine Analogs: A Comparison With the General Population.
Madanat YF, Rybicki L, Radivoyevitch T, Jagadeesh D, Dean R, Pohlman B, Kalaycio M, Sekeres MA, Smith MR, Hill BT, Clin Lymphoma Myeloma Leuk 2017 Dec 17 12 857-862
Optimizing the use of hypomethylating agents in myelodysplastic syndromes: Selecting the candidate, predicting the response, and enhancing the activity.
Madanat Y, Sekeres MA, Semin. Hematol. 2017 07 54 3 147-153
Idelalisib therapy of indolent B-cell malignancies: chronic lymphocytic leukemia and small lymphocytic or follicular lymphomas.
Madanat YF, Smith MR, Almasan A, Hill BT, Blood Lymphat Cancer 2016 6 1-6
Got zinc? An exfoliative rash in a parenteral nutrition-dependent patient.
Sidana S, Madanat Y, Pile J, J Gen Intern Med 2015 Apr 30 4 529-30


Featured Books Legend Featured Books

Honors & Awards

  • Young Investigator Award
    Acute Leukemia Forum (2019)
  • Abstract Achievement Award
    American Society of Hematology (2018)
  • Honorable Distinction Award
    Society of Hematologic Oncology (2018)
  • Abstract Achievement Award
    American Society of Hematology (2017)

Professional Associations/Affiliations

  • American College of Physicians
  • American Medical Association
  • American Society of Clinical Oncology
  • American Society of Hematology
  • MDS Foundation