Biography

Dr. Guo received a 5-year MD and a 3-year MSc degree from China. He was an established medical scientist and clinician on liver diseases before his come to US (one of few who studied polypeptides and its immunity of native HBsAg in 1980’s; one of pioneers who studied HCV genotypes collaborated with scientists in Japan in 1992). His research on PBC and PSC molecular biology at Ochsner in US has laid the ground of the hypothesis of endogenous retrovirus may triggered biliary inflammation process in PBC patient. He has patented a DNA sequence that dominantly seen in liver tissues of patient with PSC. His work on hepatitis B demonstrated the presence of HBVDNA in liver tissue in patients with evidence of HBsAg clearance and in patients with HBcAb alone. Those findings supported prophylactic antiviral therapy in liver recipients with + HBcAb-donor.

After Hepatology/Transplant fellowship at Mayo Clinic in Scottsdale, Dr. Guo Joined Baylor University Medical center as a full-time staff transplant hepatologist and a liver consultant in 2005 until 2018. He has 15 years expertise on patient’s care and clinical medicine teaching both in general and transplant hepatology. He won multiple wards such as Vital Compassionate doctor awards, Patient’s choice awards, Top Physicians in America and Best Doctors in Dallas. Now Dr. Guo is to bring the opportunity for the harmonious integration of clinical expertise, and research experience on liver diseases to our patients with an emphasis on personalized patient-centered care. He currently specializes in treatment of all liver diseases with strong interests in preventing patient to develop and/or die from liver cirrhosis. Dr. Guo would like to continually proceed his passion on teaching of liver disease integrating with his personal understanding from clinical practice and previous research.

Dr. Guo’s interests outside of medicine include art collection and appreciation.Dr. O’Leary’s interests outside of medicine include skiing, scuba diving, and playing tennis.Dr. O’Leary’s interests outside of medicine include skiing, scuba diving, and playing tennis.

Dr. Guo received a 5-year MD and a 3-year MSc degree from China. He was an established medical scientist and clinician in liver diseases before he came to the US (one of a few who studied polypeptides of native HBsAg and its immunity in 1980’s, one of pioneers who studied HCV genotypes and collaborated with scientists in Japan in 1992). His research on PBC and PSC molecular biology at Ochsner in the US has laid the ground of the hypothesis of endogenous retrovirus may triggered bile inflammation process in PBC patient. He patented a DNA sequence that dominantly seen in liver tissues of patient with PSC. His work on hepatitis B demonstrated the presence of HBVDNA in liver tissue in patients with evidence of HBsAg clearance. This finding supported prophylactic antiviral therapy in liver recipients with + HBcAb-donor.

After Hepatology/Transplant fellowship at Mayo Clinic in Scottsdale, AZ, Dr. Guo Joined Baylor University Medical center as a full-time staff transplant hepatologist and a liver consultant in 2005 until 2018. He has 15 years expertise in patient care and clinical medicine teaching both in general and transplant hepatology. He won multiple wards such as Vital Compassionate doctor awards, Patient’s choice awards, Top Physicians in America and Best Doctors in Dallas. Now Dr. Guo is bringing the opportunity for the harmonious integration of clinical expertise, and research experience in liver diseases to our patients with an emphasis on personalized patient-centered care. He currently specializes in treatment of all liver diseases with strong interests in preventing the development and/or death from liver cirrhosis. Dr. Guo also has strong passion in the teaching of liver disease integrating with his personal understanding from clinical practice and previous research.

Dr. Guo’s interests outside of medicine include art collecting and appreciation. 

Research Interest

  • Management of Chronic Hepatitis B
  • Preventing Development of and Managing Liver Decompensation
  • Severe Alchoholic Hepatitis

Publications

Featured Publications LegendFeatured Publications

Duplication of MER115 on chromosome 4 in patients with primary biliary cirrhosis.
Xu L, Guo L, Shen Z, Loss G, Gish R, Wasilenko S, Mason AL Liver Int. 2009 Mar 29 3 375-83
Living donor liver transplantation for hepatitis C-related cirrhosis: no difference in histological recurrence when compared to deceased donor liver transplantation recipients.
Guo L, Orrego M, Rodriguez-Luna H, Balan V, Byrne T, Chopra K, Douglas DD, Harrison E, Moss A, Reddy KS, Williams JW, Rakela J, Mulligan D, Vargas HE Liver Transpl. 2006 Apr 12 4 560-5
Hepatic B-cell non-Hodgkin's lymphoma of MALT type in the liver explant of a patient with chronic hepatitis C infection.
Orrego M, Guo L, Reeder C, De Petris G, Balan V, Douglas DD, Byrne T, Harrison E, Mulligan D, Rodriguez-Luna H, Moss A, Reddy K, Rakela J, Vargas HE Liver Transpl. 2005 Jul 11 7 796-9
Does a betaretrovirus infection trigger primary biliary cirrhosis?
Xu L, Shen Z, Guo L, Fodera B, Keogh A, Joplin R, O'Donnell B, Aitken J, Carman W, Neuberger J, Mason A Proc. Natl. Acad. Sci. U.S.A. 2003 Jul 100 14 8454-9
GP73, a novel Golgi-localized protein upregulated by viral infection.
Kladney RD, Bulla GA, Guo L, Mason AL, Tollefson AE, Simon DJ, Koutoubi Z, Fimmel CJ Gene 2000 May 249 1-2 53-65
Molecular basis for persistent hepatitis B virus infection in the liver after clearance of serum hepatitis B surface antigen.
Mason AL, Xu L, Guo L, Kuhns M, Perrillo RP Hepatology 1998 Jun 27 6 1736-42
Detection of retroviral antibodies in primary biliary cirrhosis and other idiopathic biliary disorders.
Mason AL, Xu L, Guo L, Munoz S, Jaspan JB, Bryer-Ash M, Cao Y, Sander DM, Shoenfeld Y, Ahmed A, Van de Water J, Gershwin ME, Garry RF Lancet 1998 May 351 9116 1620-4
Hepatitis B virus DNA in serum and liver is commonly found in Chinese patients with chronic liver disease despite the presence of antibodies to HBsAg.
Zhang YY, Hansson BG, Kuo LS, Widell A, Nordenfelt E Hepatology 1993 Apr 17 4 538-44
Analysis of antigenic polypeptides of Dane particles and antibody response ability of HBV infected subjects to PreS1 polypeptides.
Guo LS, Li FH, Yang DL, Song PH, Hao LJ J. Tongji Med. Univ. 1992 12 1 48-53

Books

Featured Books Legend Featured Books

Honors & Awards

  • Vital Compassionate Doctor
    American Registry Honors Physicians (2018)
  • Vital Patient's Choice Award
    American Registry Honors Physicians (2018)
  • Best Doctor
    D Magazine (2017)
  • Vital Patient's Choice Award
    American Registry Honors Physicians (2017)
  • America's Top Physicians
    Consumers Research Countil of America (2016-2018)
  • Best Doctor
    D Magazine (2016)
  • Vital Compassionate Doctor
    American Registry Honors Physicians (2014)
  • Vital Patient's Choice Award
    American Registry Honors Physicians (2014)
  • America's Top Physicians
    Consumers Research Council of America (2008-2014)

Professional Associations/Affiliations

  • American Association for the Study of Liver Diseases (AASLD) (2005)