Li Li, Ph.D. Instructor School Medical School Department Internal Medicine Biography Li Li, Ph.D., is an Instructor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of the Center for Hypothalamic Research. Dr. Li earned his Ph.D. from the John R. Speakman Laboratory at the Institute of Genetics and Developmental Biology at the Chinese Academy of Sciences (IGDB-CAS). To gain expertise in neuronal control of metabolism, he joined Dr. Chen Liu’s laboratory at UT Southwestern Medical Center in 2018, focusing on the neuronal mechanisms of appetite regulation. Dr. Li's research interests include antipsychotic drugs induced metabolic syndrome and serotonin receptor pathways in appetite control. His long-term research goal is to uncover the key mechanisms underlying obesity and diabetes and to develop effective therapeutic strategies to address these clinical challenges. Dr. Li is active in several professional societies including, the American Heart Association, The Obesity Society, and The Society for the Study of Ingestive Behavior. Dr. Li's interests outside of research include his family, cooking, reading, and the great outdoors. Research Interest Antipsychotic drugs induced metabolic syndrome Serotonin receptor pathways in appetite control Publications Featured Publications Functional coupling between MC4R and Kir7.1 contributes to clozapine-induced hyperphagia. Li L, Hernandez CC, Gimenez LE, Xu B, Dahir NS, SwatiBirnbaum SG, Cone RD, Liu C, bioRxiv 2024 Jun The hedonic overdrive model best explains high-fat diet-induced obesity in C57BL/6 mice. Gao L, Hu S, Yang D, Wang L, Togo J, Wu Y, Li B, Li M, Wang G, Zhang X, Li L, Xu Y, Mazidi M, Couper E, Whittington-Davies A, Niu C, Speakman JR, Obesity (Silver Spring) 2024 Apr 32 4 733-742 Hyperleptinemia contributes to antipsychotic drug-associated obesity and metabolic disorders. Zhao S, Lin Q, Xiong W, Li L, Straub L, Zhang D, Zapata R, Zhu Q, Sun XN, Zhang Z, Funcke JB, Li C, Chen S, Zhu Y, Jiang N, Li G, Xu Z, Wyler SC, Wang MY, Bai J, Han X, Kusminski CM, Zhang N, An Z, Elmquist JK, Osborn O, Liu C, Scherer PE, Sci Transl Med 2023 Nov 15 723 eade8460 Maternal High Fat Diet in Lactation Impacts Hypothalamic Neurogenesis and Neurotrophic Development, Leading to Later Life Susceptibility to Obesity in Male but Not Female Mice. Xu Y, Yang D, Wang L, Król E, Mazidi M, Li L, Huang Y, Niu C, Liu X, Lam SM, Shui G, Douglas A, Speakman JR, Adv Sci (Weinh) 2023 Oct e2305472 Sample enrichment for single-nucleus sequencing using concanavalin A-conjugated magnetic beads. Li L, Xu B, Liu C, STAR Protoc 2023 Sep 4 4 102595 Delineating a serotonin 1B receptor circuit for appetite suppression in mice. Li L, Wyler SC, León-Mercado LA, Xu B, Oh Y, SwatiChen X, Wan R, Arnold AG, Jia L, Wang G, Nautiyal K, Hen R, Sohn JW, Liu C, J Exp Med 2022 Aug 219 8 Calorie restriction and calorie dilution have different impacts on body fat, metabolism, behavior, and hypothalamic gene expression. Liu X, Jin Z, Summers S, Derous D, Li M, Li B, Li L, Speakman JR, Cell Rep 2022 May 39 7 110835 Effects of dietary macronutrients on the hepatic transcriptome and serum metabolome in mice. Wu Y, Green CL, Wang G, Yang D, Li L, Li B, Wang L, Li M, Li J, Xu Y, Zhang X, Niu C, Hu S, Togo J, Mazidi M, Derous D, Douglas A, Speakman JR, Aging Cell 2022 Mar e13585 A single nucleotide mutation in the dual-oxidase 2 (DUOX2) gene causes some of the panda's unique metabolic phenotypes. Rudolf AM, Wu Q, Li L, Wang J, Huang Y, Togo J, Liechti C, Li M, Niu C, Nie Y, Wei F, Speakman JR, Natl Sci Rev 2022 Feb 9 2 nwab125 Increased Variation in Body Weight and Food Intake Is Related to Increased Dietary Fat but Not Increased Carbohydrate or Protein in Mice. Wu Y, Hu S, Yang D, Li L, Li B, Wang L, Li M, Wang G, Li J, Xu Y, Zhang X, Niu C, Speakman JR, Front Nutr 2022 9 835536 Results 1-10 of 24 1 2 3 Next Last Honors & Awards Best Poster AwardGordon Research Conference Hypothalamus (2024) Career Development AwardAmerican Heart Association (2024) Oral presentation AwardThe 15th CADA Annual Meeting (2024) 1st place in Donald Seldin Symposium Basic Science AwardUT Southwestern Medical Center (2023) American Heart Association Postdoctoral FellowshipAmerican Heart Association (2023) FinalistBrown-Goldstein Award for Excellence in Postdoctoral Research (2023) Future of Science Fund scholarshipKeystone Symposia (2022) Postdoctoral Association Travel AwardUT Southwestern Medical Center (2022) Professional Associations/Affiliations American Heart Association The Obesity Society The Society for the Study of Ingestive Behavior
