Daisuke Hattori, Ph.D.

Daisuke Hattori received his bachelor's degree from University of Tokyo in Japan. His thesis project in Masanori Taira’s lab focused on the early development of vertebrate brain. For his graduate work in Larry Zipursky's lab at University of California, Los Angeles, Daisuke studied molecular mechanisms that mediate neural circuit assembly. His work contributed to demonstrating that the diversity encoded by Drosophila Dscam1 gene generates neuronal identity labels and this is essential to mediate neurite self-avoidance. As a postdoc in Richard Axel's lab at Columbia University, Daisuke studied the anatomy and function of a neural circuit that supports learning and memory. He contributed to a study that identified a complete circuit diagram of Drosophila learning center, the mushroom body. In addition, his work revealed a simple dopamine-dependent neural mechanism in the mushroom body that mediates detection of novelty and transition to familiarity. In 2018, Daisuke joined the faculty in the Department of Physiology with a secondary appointment in the Department of Neuroscience.

The Hattori lab studies how neural circuits integrate sensorimotor information, memory, and internal state to guide behavior. We use Drosophila as a primary model and employ a multidisciplinary approach that encompasses molecular genetics, neural recording, behavioral experiments, and computational modeling.

Contact Daisuke by email at:
daisuke.hattori@utsouthwestern.edu

Undergraduate

University of Tokyo (2002), Biological Sciences

Graduate School

University of California-Los A (2009), Biological Chemistry

Featured Publications

A rapid and bidirectional reporter of neural activity reveals neural correlates of social behaviors in Drosophila.

Bonheur M, Swartz KJ, Metcalf MG, Wen X, Zhukovskaya A, Mehta A, Connors KE, Barasch JG, Jamieson AR, Martin KC, Axel R, Hattori D, Nat Neurosci 2023 Jul 26 7 1295-1307

A neural theory for counting memories.

Dasgupta S, Hattori D, Navlakha S, Nat Commun 2022 Oct 13 1 5961

Representations of Novelty and Familiarity in a Mushroom Body Compartment.

Hattori D, Aso Y, Swartz KJ, Rubin GM, Abbott LF, Axel R Cell 2017 May 169 5 956-969.e17

The neuronal architecture of the mushroom body provides a logic for associative learning.

Aso Y, Hattori D, Yu Y, Johnston RM, Iyer NA, Ngo TT, Dionne H, Abbott LF, Axel R, Tanimoto H, Rubin GM Elife 2014 3 e04577

Robust discrimination between self and non-self neurites requires thousands of Dscam1 isoforms.

Hattori D, Chen Y, Matthews BJ, Salwinski L, Sabatti C, Grueber WB, Zipursky SL Nature 2009 Oct 461 7264 644-8

Dscam-mediated cell recognition regulates neural circuit formation.

Hattori D, Millard SS, Wojtowicz WM, Zipursky SL Annu. Rev. Cell Dev. Biol. 2008 24 597-620

Dscam diversity is essential for neuronal wiring and self-recognition.

Hattori D, Demir E, Kim HW, Viragh E, Zipursky SL, Dickson BJ Nature 2007 Sep 449 7159 223-7

Dendrite self-avoidance is controlled by Dscam.

Matthews BJ, Kim ME, Flanagan JJ, Hattori D, Clemens JC, Zipursky SL, Grueber WB Cell 2007 May 129 3 593-604

Got diversity? Wiring the fly brain with Dscam.

Zipursky SL, Wojtowicz WM, Hattori D Trends Biochem. Sci. 2006 Oct 31 10 581-8

DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling.

Fan G, Martinowich K, Chin MH, He F, Fouse SD, Hutnick L, Hattori D, Ge W, Shen Y, Wu H, ten Hoeve J, Shuai K, Sun YE Development 2005 Aug 132 15 3345-56

• Jane Coffin Childs Memorial Fund
  Postdoctoral Fellowship (2010-2013)