Subhransu Sahoo, Ph.D. Titles and Appointments Instructor Schools Medical School | Graduate School Departments Radiation Oncology Graduate Programs Cancer Biology Biography Subhransu Sahoo, Ph.D., is an Instructor in the Department of Radiation Oncology at UT Southwestern Medical Center. He is faculty in the Section of Molecular Medicine and a member of the Alluri Lab. Dr. Sahoo earned his master’s degree in human genetics from the National Institute of Science Education and Research in Bhubaneswar, India. He then completed his Ph.D. studies in cancer biology at The University of Newcastle in New South Wales, Australia. A main focus of Dr. Sahoo's research is on elucidating how transcriptional regulation, epigenetic reprogramming, and interactions with the tumor microenvironment drive cancer progression and therapeutic resistance. His research aims to uncover the tumor-intrinsic molecular mechanisms and signaling pathways that contribute to treatment resistance and to determine whether targeting these pathways can enhance therapeutic efficacy and improve tumor control. Dr. Sahoo has contributed to several publications focusing on the molecular mechanisms that regulate endometrial development, epithelial differentiation, and cancer progression. His research has highlighted the role of PAX2 as a tumor suppressor in endometrial cancer, uncovering how epigenetic reprogramming, loss of active chromatin regulation, and superenhancer disruption contribute to PAX2 silencing and tumorigenesis. Research Interest Cancer biology Cancer genetics Tumor intrinsic resistance mechanism Tumor microenvironment and metabolism Publications Featured Publications A distinct mechanism of epigenetic reprogramming silences PAX2 and initiates endometrial carcinogenesis Sahoo SS, Ramanand SG, Cuevas IC, Gao Y, Lee S, Abbas A, Zhang X, Kumar A, Koduru P, Roy S, Broaddus RR, Bae-Jump VL, Gladden AB, Lea J, Lucas E, Xing C, Kobayashi A, Mani RS, Castrillon DH, J Clin Invest 2025 Endometrial polyps are non-neoplastic but harbor epithelial mutations in endometrial cancer drivers at low allelic frequencies. Sahoo SS, Aguilar M, Xu Y, Lucas E, Miller V, Chen H, Zheng W, Cuevas IC, Li HD, Hitrys D, Wachsmann MB, Bishop JA, Cantarell B, Gagan J, Koduru P, SoRelle JA, Castrillon DH, Mod Pathol 2022 Jul FOXA2 suppresses endometrial carcinogenesis and epithelial-mesenchymal transition by regulating enhancer activity. Sahoo SS, Ramanand SG, Gao Y, Abbas A, Kumar A, Cuevas IC, Li HD, Aguilar M, Xing C, Mani RS, Castrillon DH, J Clin Invest 2022 06 132 12 Fbxw7 is a driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition. Cuevas IC, Sahoo SS, Kumar A, Zhang H, Westcott J, Aguilar M, Cortez JD, Sullivan SA, Xing C, Hayes DN, Brekken RA, Bae-Jump VL, Castrillon DH, Proc Natl Acad Sci U S A 2019 12 116 51 25880-25890 The Emerging Role of the Microenvironment in Endometrial Cancer. Sahoo SS, Zhang XD, Hondermarck H, Tanwar PS, Cancers (Basel) 2018 Oct 10 11 Adipose-Derived VEGF-mTOR Signaling Promotes Endometrial Hyperplasia and Cancer: Implications for Obese Women. Sahoo SS, Lombard JM, Ius Y, O'Sullivan R, Wood LG, Nahar P, Jaaback K, Tanwar PS, Mol Cancer Res 2018 02 16 2 309-321 Inhibition of extracellular matrix mediated TGF-? signalling suppresses endometrial cancer metastasis. Sahoo SS, Quah MY, Nielsen S, Atkins J, Au GG, Cairns MJ, Nahar P, Lombard JM, Tanwar PS, Oncotarget 2017 Sep 8 42 71400-71417 Reliable Identification of Endometrial Precancers Through Combined Pax2, ?-Catenin, and Pten Immunohistochemistry. Aguilar M, Chen H, Rivera-Colon G, Niu S, Carrick K, Gwin K, Cuevas IC, Sahoo SS, Li HD, Zhang S, Zheng W, Lucas E, Castrillon DH, Am J Surg Pathol 2022 03 46 3 404-414 A PoleP286R mouse model of endometrial cancer recapitulates high mutational burden and immunotherapy response. Li HD, Lu C, Zhang H, Hu Q, Zhang J, Cuevas IC, Sahoo SS, Aguilar M, Maurais EG, Zhang S, Wang X, Akbay EA, Li GM, Li B, Koduru P, Ly P, Fu YX, Castrillon DH, JCI Insight 2020 07 5 14 Results 1-9 of 9 1 Honors & Awards Society for Reproductive Biology Travel Grant (2018) Beautiful Science Award, The University of Newcastle (2017) Lorne Cancer Conference Travel Grant (2016) Professional Associations/Affiliations American Association for Cancer Research (2020) Society for Reproductive Biology (2018)
