
Mark Henkemeyer, Ph.D.
Professor
Endowed Title Dick and Martha Brooks Professorship in Nerve Growth Research
School Medical School
Department Neuroscience
Graduate Programs Neuroscience
Education
- Undergraduate
- University of Minnesota-Twin C (1984), Cell Biology
- Undergraduate
- University of Minnesota-Twin C (1984), Genetics
- Graduate School
- Uni of Wisconsin-Madison (1990), Oncology
Research Interest
- Axon Guidance, Synaptic development, Plasticity
- Brain Development
- Ephrin-Eph Bidirectional Signaling
- Neuropathic Pain, Alzheimer's Disease, Autism
Publications
Featured Publications
- Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain.
- Ahmed MS, Wang P, Nguyen NUN, Nakada Y, Menendez-Montes I, Ismail M, Bachoo R, Henkemeyer M, Sadek HA, Kandil ES, Proc Natl Acad Sci U S A 2021 Mar 118 10
- EphB2 receptor cell-autonomous forward signaling mediates auditory memory recall and learning-driven spinogenesis.
- Talebian A, Henkemeyer M, Commun Biol 2019 2 372
- EphB2 receptor tyrosine kinase promotes hepatic fibrogenesis in mice via activation of hepatic stellate cells.
- Mimche PN, Lee CM, Mimche SM, Thapa M, Grakoui A, Henkemeyer M, Lamb TJ, Sci Rep 2018 02 8 1 2532
- Autonomous and non-autonomous roles for ephrin-B in interneuron migration.
- Talebian A, Britton R, Ammanuel S, Bepari A, Sprouse F, Birnbaum SG, Szabó G, Tamamaki N, Gibson J, Henkemeyer M Dev. Biol. 2017 Sep
- A dual shaping mechanism for postsynaptic ephrin-B3 as a receptor that sculpts dendrites and synapses.
- Xu NJ, Sun S, Gibson JR, Henkemeyer M Nat. Neurosci. 2011 Nov 14 11 1421-9
- EphB2 tyrosine kinase-dependent forward signaling in migration of neuronal progenitors that populate and form a distinct region of the dentate niche.
- Catchpole T, Henkemeyer M J. Neurosci. 2011 Aug 31 32 11472-83
- Ephrin-B reverse signaling controls septation events at the embryonic midline through separate tyrosine phosphorylation-independent signaling avenues.
- Dravis C, Henkemeyer M Dev. Biol. 2011 Jul 355 1 138-51
- Ephrin-B3 reverse signaling through Grb4 and cytoskeletal regulators mediates axon pruning.
- Xu NJ, Henkemeyer M Nat. Neurosci. 2009 Mar 12 3 268-76
- Ephrins in reverse, park and drive.
- Cowan CA, Henkemeyer M, Trends Cell Biol 2002 Jul 12 7 339-46
- The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals.
- Cowan CA, Henkemeyer M Nature 2001 Sep 413 6852 174-9
Honors & Awards
- Rita Allen Foundation Scholar
(2002-2005) - Bristol-Myers Squibb postdoctoral fellowship
(1994-1996) - Medical Research Council of Canada postdoctoral fellowship
(1990-1993) - E.I. Du Pont De Nemours and Company graduate student fellowship
(1989-1990) - Graduated summa cum laude
(1984) - National Cancer Institute predoctoral training grant
(1984-1989)