Mark Henkemeyer, Ph.D. Titles and Appointments Professor Endowed Title Dick and Martha Brooks Professorship in Nerve Growth Research Schools Medical School | Graduate School Departments Neuroscience Graduate Programs Neuroscience Education Undergraduate University of Minnesota-Twin C (1984), Cell Biology Undergraduate University of Minnesota-Twin C (1984), Genetics Graduate School Uni of Wisconsin-Madison (1990), Oncology Research Interest 1. Ephrin-Eph Bidirectional cell-cell Signaling in Development and Disease 2. Brain Development, Axon Guidance and Pathfinding, Synapse Formation, Maturation, Plasticity, Learning and Memory 3. Neurological Diseases, Spinal Cord, Chronic Pain, Neuropathic Pain 4. Inflammatory/Fibrotic Diseases of the Skin, Liver, Kidney 5. Metabolic Disorders and Obesity Publications Featured Publications Eph-Ephrin Tetramerization Inhibitors Target Bidirectional Signaling to Combat Pain and Addiction. Wang H, Khambete A, Sprouse F, Karsi M, Cortez K, Bellinghausen E, Khuu T, Block N, Talebian A, Ahmed MS, Gedara MU, Ortiz M, Henkemeyer M, bioRxiv 2025 Dec Proteinaceous Metal-Binding Eph-Ephrin Tetramerization is Modulated by Copper and Chelators. Khambete A, Wang H, Henkemeyer M, bioRxiv 2025 Dec Diet-induced MASH liver fibrosis promoted by EphB2 can be targeted by small molecule tetramerization inhibitors. Yoshigi M, Kamdem SD, Wang H, Khambete A, Sprouse F, Kameni EM, Atiogue E, Pellizzari S, Evason KJ, Helms MN, Goodman M, Wang S, So J, Roh HC, Boudina S, Henkemeyer M, Mimche PN, bioRxiv 2025 Dec EphB2 receptor promotes dermal fibrosis in systemic sclerosis. Egal ES, Kamdem SD, Yoshigi M, Yang CC, Pellizzari S, Kameni EM, Helms MN, Assassi S, Henkemeyer M, Frech TM, Mimche PN, Arthritis Rheumatol 2024 Apr Key role for EphB2 receptor in kidney fibrosis. Huang Z, Liu S, Tang A, Al-Rabadi L, Henkemeyer M, Mimche PN, Huang Y, Clin Sci (Lond) 2021 Aug Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain. Ahmed MS, Wang P, Nguyen NUN, Nakada Y, Menendez-Montes I, Ismail M, Bachoo R, Henkemeyer M, Sadek HA, Kandil ES, Proc Natl Acad Sci U S A 2021 Mar 118 10 EphB2 receptor tyrosine kinase promotes hepatic fibrogenesis in mice via activation of hepatic stellate cells. Mimche PN, Lee CM, Mimche SM, Thapa M, Grakoui A, Henkemeyer M, Lamb TJ, Sci Rep 2018 02 8 1 2532 Ephrin-B3 reverse signaling through Grb4 and cytoskeletal regulators mediates axon pruning. Xu NJ, Henkemeyer M Nat. Neurosci. 2009 Mar 12 3 268-76 Ephrins in reverse, park and drive. Cowan CA, Henkemeyer M, Trends Cell Biol 2002 Jul 12 7 339-46 The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals. Cowan CA, Henkemeyer M Nature 2001 Sep 413 6852 174-9 Results 1-10 of 81 1 2 3 4 5 Next Last Honors & Awards Commercialization Innovation PrizeBoehringer Ingelheim and UT Arlington (2024) Lyda Hill Philanthropies Commercialization Milestone AwardUTSW Biotech+ at Pegasus Park (2022) Carl B. and Florence E. King Endowed Fund in Alzheimers Disease (2013) Rita Allen Foundation Scholar (2002-2005) Bristol-Myers Squibb postdoctoral fellowship (1994-1996) Medical Research Council of Canada postdoctoral fellowship (1990-1993) E.I. Du Pont De Nemours and Company graduate student fellowship (1989-1990) Graduated summa cum laude (1984) National Cancer Institute predoctoral training grant (1984-1989)
