Stephen Chung, M.D. Titles and Appointments Assistant Professor School Medical School Department Internal Medicine | Children's Medical Center Research Institute at UT Southwestern Graduate Programs Cancer Biology You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Stephen Chung, M.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of the Division of Hematology and Oncology, He is part of the Children’s Research Institute at UT Southwestern Medical Center. Originally from Highland Park, Illinois, Dr. Chung holds a bachelor's degree in biology and biochemistry from Cornell University in Ithaca, New York. He earned his medical degree at Washington University School of Medicine in St. Louis. He completed a residency in internal medicine at Massachusetts General Hospital in Boston followed by a medical oncology fellowship at Memorial Sloan Kettering Cancer Center in New York. As a postdoctoral fellow in the Human Oncology and Pathogenesis Program at MSKCC, Dr. Chung’s work led to the identification of the hematopoietic stem cell as the cell of origin for hairy cell leukemia, as well as the identification of CD99 as a disease stem cell marker and therapeutic target in cancer treatments. Certified by the American Board of Internal Medicine in medical oncology, Dr. Chung joined the UT Southwestern faculty in 2018. Dr. Chung’s laboratory research focuses on studying the molecular alterations in the hematopoietic (blood-forming) stem cells that underlie the development of AML and MDS. By studying these immature blood cells he aims to better understand what causes these diseases, as well as the mechanisms by which they sometimes become resistant to standard therapies. He is also interested in identifying novel alterations in cell surface protein expression in these diseases to identify new therapeutic targets and to develop new diagnostic tests. Dr. Chung's clinical interest is the care of patients with clonal hematopoiesis, the myelodysplastic syndromes, and acute myeloid leukemia. Dr. Chung is a member of the American College of Physicians, the Dallas County Medical Society, the American Society of Clinical Oncology, the American Society of Hematology, and the International Society for Experimental Hematology. Education Medical School Washington University School of Medicine (2006) Residency Massachusetts General Hospital (2009), Internal Medicine Fellowship Memorial Sloan-Kettering Cancer Center (2012), Medical Oncology Research Interest Acute Myeloid Leukemia Clonal Hematopoiesis Hematopoiesis Leukemia Stem Cells The Myelodysplastic Syndromes Publications Featured Publications TET2-mutant Clonal Hematopoiesis Promotes Heart Failure with Preserved Ejection Fraction. Pandey A, Thomas T, Ji Y, Kroger B, Irion CI, Kalkan F, Segar M, Subramanian V, Genis AB, Hu W, Son A, Young KA, Trowbridge JJ, Carlsgaard P, Premnath N, Jiang N, Daou D, Ware SA, Tong D, Chung SS Circulation 2025 (in press) Non-selective b adrenergic receptor inhibitors impair hematopoietic regeneration in mice and humans after hematopoietic cell transplants. Nishino J, Hu W, Kishtagari A, Shen B, Gao X, Blackman CM, Kassim A, Marneni N, Cherukuri AV, Vittrup R, Kalkan FN, Shah R, Ahn C, Gao A, Ahmedrabie A, Collins RH, Zeidan AM, Bidikian A, Gowda L, Shaffer BC, Madanat YF, Zhao Z, Chung SS, Morrison SJ Cancer Discov 2024 CD99 is a therapeutic target on disease stem cells in myeloid malignancies. Chung SS, Eng WS, Hu W, Khalaj M, Garrett-Bakelman FE, Tavakkoli M, Levine RL, Carroll M, Klimek VM, Melnick AM, Park CY Sci Transl Med 2017 01 9 374 Hematopoietic stem cell origin of BRAFV600E mutations in hairy cell leukemia. Chung SS, Kim E, Park JH, Chung YR, Lito P, Teruya-Feldstein J, Hu W, Beguelin W, Monette S, Duy C, Rampal R, Telis L, Patel M, Kim MK, Huberman K, Bouvier N, Berger MF, Melnick AM, Rosen N, Tallman MS, Park CY, Abdel-Wahab O Sci Transl Med 2014 May 6 238 238ra71 Real world efficacy of luspatercept in patients with lower-risk myelodysplastic syndromes/neoplasms (MDS); a single center study in a heavily pretreated cohort. Kometas ML, Hoff FW, Hyak J, Irizarry-Gatell V, Marinos Velarde A, Jackson C, Anderson J, Kalkan FN, Ramakrishnan Geethakumari P, Alvarenga Thiebaud J, Chen W, Weinberg OK, Cantu MD, Collins RH, Chung SS, Madanat YF, Leuk Lymphoma 2025 Mar 1-9 CD44-Mediated Metabolic Rewiring is A Targetable Dependency of IDH-Mutant Leukemia. Lyu J, Liu Y, Liu N, Vu H, Cai F, Cao H, Kaphle P, Wu Z, Botten GA, Zhang Y, Wang J, Achyutuni S, Gao X, Iacobucci I, Mullighan CG, Chung SS, Ni M, DeBerardinis RJ, Xu J, Blood 2025 Jan RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax. Sango J, Carcamo S, Sirenko M, Maiti A, Mansour H, Ulukaya G, Tomalin LE, Cruz-Rodriguez N, Wang T, Olszewska M, Olivier E, Jaud M, Nadorp B, Kroger B, Hu F, Silverman L, Chung SS, Wagenblast E, Chaligne R, Eisfeld AK, Demircioglu D, Landau DA, Lito P, Papaemmanuil E, DiNardo CD, Hasson D, Konopleva M, Papapetrou EP, Nature 2024 Oct Impact of the Affordable Care Act and Medicaid Expansion Among Patients With HIV-Associated Aggressive B-Cell Non-Hodgkin Lymphomas. Premnath N, Liu Y, Reves H, Pandey U, Nair RG, Anderson J, Afrough A, Anderson LD, Chung SS, Kaur G, Khan AM, Kumar KA, Madanat YF, Wolfe HR, Yilmaz E, Awan FT, Sweetenham J, Ramakrishnan Geethakumari P, JCO Oncol Pract 2024 Oct OP2400354 Risk Prediction for Clonal Cytopenia: Multicenter Real-World Evidence. Xie Z, Komrokji RS, Al-Ali N, Regelson A, Geyer S, Patel AA, Saygin C, Zeidan AM, Bewersdorf JP, Mendez LM, Kishtagari A, Zeidner JF, Coombs CC, Madanat YF, Chung SS, Badar T, Foran JM, Desai P, Tsai C, Griffiths EA, Al Malki MM, Amanam I, Lai C, Deeg HJ, Ades L, Arana-Yi C, Osman AE, Dinner SN, Abaza Y, Taylor J, Chandhok NS, Soong D, Brunner AM, Carraway HE, Singh A, Elena C, Ferrari J, Galli A, Pozzi S, Padron E, Patnaik MM, Malcovati L, Savona MR, Al-Kali A, Blood 2024 Jul Racial and ethnic disparities in Acute Myeloid Leukemia: 15-year experience at a safety net hospital system. Dong S, Premnath N, Sadeghi N, Kainthla R, Chung SS, Collins RH, Li HC, Madanat YF, Leuk Res 2024 Apr 141 107503 Results 1-10 of 32 1 2 3 4 Next Last Books Featured Books Acute Myeloid Leukemia Stem Cells. In Cancer Stem Cells Chung SS, Park CY (2014). Wiley Honors & Awards Individual Investigator Research AwardCancer Prevention Institute of Texas (2025) R37 MERIT AwardNational Cancer Institute (2023) Discovery Research GrantEvans MDS Foundation (2022) Idea Development AwardDoD Rare Cancers Research Program (2022) Junior Faculty Scholar Award in Basic/Translational ResearchAmerican Society of Hematology (2020-2022) Cancer Prevention and Research Institute of Texas ScholarFirst time tenure-track faculty member (2018-2023) Disease-Oriented Clinical ScholarUT Southwestern (2018-2021) Clinical Scientist Research Career Development Award (K08)NCI (2017) Paul Sherlock Housestaff Teaching AwardMSKCC Department of Medicine (2017) Fellow Scholar Award in Basic/Translational ResearchAmerican Society of Hematology (2015-2017) Postdoctoral Research AwardBone Marrow Failure Research Program, Department of Defense (2013-2015) Young Investigator AwardAmerican Socity of Clinical Oncology (2012) Professional Associations/Affiliations American Society of Hematology (2009) International Society for Experimental Hematology (2013)
