Shuang Liang, Ph.D.

• Alcoholic & non-alcoholic steatohepatitis
• Hepatocellular carcinoma
• Liver fibrosis
• Sterile inflammation

Featured Publications

Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development.

Wang X, He Q, Zhou C, Xu Y, Liu D, Fujiwara N, Kubota N, Click A, Henderson P, Vancil J, Marquez CA, Gunasekaran G, Schwartz ME, Tabrizian P, Sarpel U, Fiel MI, Diao Y, Sun B, Hoshida Y, Liang S, Zhong Z, Immunity 2022 Dec

Murine macrophage autophagy protects against alcohol-induced liver injury by degrading interferon regulatory factor 1 (IRF1) and removing damaged mitochondria.

Liang S, Zhong Z, Kim SY, Uchiyama R, Roh YS, Matsushita H, Gottlieb RA, Seki E, J. Biol. Chem. 2019 Jun

NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice.

Liang S, Ma HY, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, Ganguly S, Lan T, Karin M, Kisseleva T, Brenner DA Gastroenterology 2018 Nov

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation.

Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M Nature 2018 Aug 560 7717 198-203

The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts.

Liang S, Kisseleva T, Brenner DA Front Physiol 2016 7 17

Molecular signatures of long-term hepatocellular carcinoma risk in nonalcoholic fatty liver disease.

Fujiwara N, Kubota N, Crouchet E, Koneru B, Marquez CA, Jajoriya AK, Panda G, Qian T, Zhu S, Goossens N, Wang X, Liang S, Zhong Z, Lewis S, Taouli B, Schwartz ME, Fiel MI, Singal AG, Marrero JA, Fobar AJ, Parikh ND, Raman I, Li QZ, Taguri M, Ono A, Aikata H, Nakahara T, Nakagawa H, Matsushita Y, Tateishi R, Koike K, Kobayashi M, Higashi T, Nakagawa S, Yamashita YI, Beppu T, Baba H, Kumada H, Chayama K, Baumert TF, Hoshida Y, Sci Transl Med 2022 Jun 14 650 eabo4474

Non-degradable collagen increases liver fibrosis but not hepatocellular carcinoma in mice.

Baglieri J, Zhang C, Liang S, Liu X, Nishio T, Rosenthal SB, Dhar D, Su H, Cong M, Jia J, Hosseini M, Karin M, Kisseleva T, Brenner DA, Am J Pathol 2021 Jun

IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease.

Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY, Alexandrov LB, Koyama Y, Nishio T, Benner C, Heinz S, Rosenthal SB, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop IH, Quehenberger O, Dennis E, Saltiel A, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T, J. Hepatol. 2019 Dec

Emerging Role of Mitochondrial DNA as a Major Driver of Inflammation and Disease Progression.

Zhong F, Liang S, Zhong Z, Trends Immunol. 2019 Nov

Activated Hepatic Stellate Cells and Portal Fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice.

Nishio T, Hu R, Koyama Y, Liang S, Rosenthal SB, Yamamoto G, Karin D, Baglieri J, Ma HY, Xu J, Liu X, Dhar D, Iwaisako K, Taura K, Brenner DA, Kisseleva T, J. Hepatol. 2019 May

• American Institute for Cancer Research Investigator-initiated Grant Award
  (2023)
• CPRIT Individual Investigator Research Award
  (2020)
• American Association for the Study of Liver Diseases (AASLD) Pinnacle Research Award
  (2019)
• Keystone Symposia scholarship on Injury, Inflammation and Fibrosis
  (2017)

• American Association for the Study of Liver Diseases (2017)