Research Interest
  • Alcoholic & non-alcoholic steatohepatitis
  • Hepatocellular carcinoma
  • Liver fibrosis
  • Sterile inflammation

Publications

Featured Publications LegendFeatured Publications

Murine macrophage autophagy protects against alcohol-induced liver injury by degrading interferon regulatory factor 1 (IRF1) and removing damaged mitochondria.
Liang S, Zhong Z, Kim SY, Uchiyama R, Roh YS, Matsushita H, Gottlieb RA, Seki E, J. Biol. Chem. 2019 Jun
NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice.
Liang S, Ma HY, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, Ganguly S, Lan T, Karin M, Kisseleva T, Brenner DA Gastroenterology 2018 Nov
New mitochondrial DNA synthesis enables NLRP3 inflammasome activation.
Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M Nature 2018 Aug 560 7717 198-203
The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts.
Liang S, Kisseleva T, Brenner DA Front Physiol 2016 7 17
Emerging Role of Mitochondrial DNA as a Major Driver of Inflammation and Disease Progression.
Zhong F, Liang S, Zhong Z, Trends Immunol. 2019 Nov
The role of human cytochrome P450 2E1 in liver inflammation and fibrosis.
Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R, Quehenberger O, Davidson NO, Dennis EA, Kisseleva T, Brenner DA Hepatol Commun 2017 12 1 10 1043-1057
TRIF Differentially Regulates Hepatic Steatosis and Inflammation/Fibrosis in Mice.
Yang L, Miura K, Zhang B, Matsushita H, Yang YM, Liang S, Song J, Roh YS, Seki E Cell Mol Gastroenterol Hepatol 2017 May 3 3 469-483
Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.
Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K, Benner C, Heinz S, Bera T, Brenner DA, Kisseleva T J. Clin. Invest. 2017 Mar
NF-?B Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.
Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M Cell 2016 Feb 164 5 896-910
Promising Therapy Candidates for Liver Fibrosis.
Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH, Brenner DA, Kisseleva T Front Physiol 2016 7 47

Honors & Awards
  • CPRIT Individual Investigator Research Award
    (2020-2023)
  • American Association for the Study of Liver Diseases (AASLD) Pinnacle Research Award
    (2019-2022)
  • Keystone Symposia scholarship on Injury, Inflammation and Fibrosis
    (2017)

Professional Associations/Affiliations
  • American Association for the Study of Liver Diseases (2017)