Shuang Liang, Ph.D.
Assistant Professor

• Alcoholic & non-alcoholic steatohepatitis
• Liver cancer
• Tissue injury, inflammation and fibrosis

Featured Publications

NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice.

Liang S, Ma HY, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, Ganguly S, Lan T, Karin M, Kisseleva T, Brenner DA Gastroenterology 2018 Nov

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation.

Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M Nature 2018 Aug 560 7717 198-203

Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.

Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K, Benner C, Heinz S, Bera T, Brenner DA, Kisseleva T J. Clin. Invest. 2017 Mar

NF-?B Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.

Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M Cell 2016 Feb 164 5 896-910

The role of human cytochrome P450 2E1 in liver inflammation and fibrosis.

Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R, Quehenberger O, Davidson NO, Dennis EA, Kisseleva T, Brenner DA Hepatol Commun 2017 12 1 10 1043-1057

TRIF Differentially Regulates Hepatic Steatosis and Inflammation/Fibrosis in Mice.

Yang L, Miura K, Zhang B, Matsushita H, Yang YM, Liang S, Song J, Roh YS, Seki E Cell Mol Gastroenterol Hepatol 2017 May 3 3 469-483

Promising Therapy Candidates for Liver Fibrosis.

Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH, Brenner DA, Kisseleva T Front Physiol 2016 7 47

The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts.

Liang S, Kisseleva T, Brenner DA Front Physiol 2016 7 17

Amyloid precursor protein (APP) affects global protein synthesis in dividing human cells.

Sobol A, Galluzzo P, Liang S, Rambo B, Skucha S, Weber MJ, Alani S, Bocchetta M J. Cell. Physiol. 2015 May 230 5 1064-74

TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis.

Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky JM, Karin M, Brenner DA, Seki E J. Clin. Invest. 2014 Jul

• Keystone Symposia scholarship on Injury, Inflammation and Fibrosis
  (2017)

• American Association for the Study of Liver Diseases (2017-2018)