Yujin Hoshida, M.D., Ph.D.
Associate Professor

Download Curriculum Vitae

Dr. Hoshida received an M.D. from University of Tsukuba, and completed internal medicine residency and fellowship training for clinical gastroenterology and hepatology, diagnostic pathology, diagnostic and interventional radiology, and biostatistics at University of Tokyo and Toranomon Hospital in Japan. He earned a Ph.D. in medical sciences from University of Tokyo, Graduate School of Medicine. After postdoctoral training for cancer genomics and systems biology at University of Tokyo, Research Center for Advanced Science and Technology and Broad Institute of MIT and Harvard University, he was recruited as faculty at Mount Sinai School of Medicine, Tisch Cancer Institute (2012-2018), and was later recruited to UT Southwestern to direct Liver Tumor Translational Research Program (2018-) and to join one of the nation’s largest liver cancer clinical care and research teams.

Dr. Hoshida has expertise in molecular classification, prognostic prediction, molecular targeted therapies, and chemoprevention in liver cirrhosis and cancer. He has been leading several international translational liver cirrhosis/cancer genomics projects, including Precision Liver Cancer Prevention Consortium, utilizing high-throughput omics technologies and integrative clinical and cross-species systems biology analysis over the past decade. The current focuses of his team include liver cancer risk-predictive molecular biomarkers specific to clinical contexts (e.g., geographic region, liver disease etiology, and patient race/ethnicity), individual risk-stratified personalized cancer screening based on cost-effectiveness, chemoprevention target discovery, radiogenomics, molecular subtype-guided liver cancer therapies, and informatics methodology and software by utilizing patient-derived tissues/cells, liquid biopsy of circulating biomolecules, single-cell omics, molecular digital spatial tissue profiling, clinical diagnostic platforms, nanomedicine technologies, and high-power computation.

• Liver cancer
• Liver cirrhosis
• Molecular classification
• Precision medicine
• Prognostic prediction

Featured Publications

Molecular signatures of long-term hepatocellular carcinoma risk in nonalcoholic fatty liver disease.

Fujiwara N, Kubota N, Crouchet E, Koneru B, Marquez CA, Jajoriya AK, Panda G, Qian T, Zhu S, Goossens N, Wang X, Liang S, Zhong Z, Lewis S, Taouli B, Schwartz ME, Fiel MI, Singal AG, Marrero JA, Fobar AJ, Parikh ND, Raman I, Li QZ, Taguri M, Ono A, Aikata H, Nakahara T, Nakagawa H, Matsushita Y, Tateishi R, Koike K, Kobayashi M, Higashi T, Nakagawa S, Yamashita YI, Beppu T, Baba H, Kumada H, Chayama K, Baumert TF, Hoshida Y, Sci Transl Med 2022 Jun 14 650 eabo4474

Molecular signature predictive of long-term liver fibrosis progression to inform anti-fibrotic drug development.

Qian T, Fujiwara N, Koneru B, Ono A, Kubota N, Jajoriya AK, Tung MG, Crouchet E, Song WM, Marquez CA, Panda G, Hoshida A, Raman I, Li QZ, Lewis C, Yopp A, Rich NE, Singal AG, Nakagawa S, Goossens N, Higashi T, Koh AP, Bian CB, Hoshida H, Tabrizian P, Gunasekaran G, Florman S, Schwarz ME, Hiotis SP, Nakahara T, Aikata H, Murakami E, Beppu T, Baba H, Warren A, Bhatia S, Kobayashi M, Kumada H, Fobar AJ, Parikh ND, Marrero JA, Rwema SH, Nair V, Patel M, Kim-Schulze S, Corey K, O'Leary JG, Klintmalm GB, Thomas DL, Dibas M, Rodriguez G, Zhang B, Friedman SL, Baumert TF, Fuchs B, Chayama K, Zhu S, Chung RT, Hoshida Y, Gastroenterology 2021 Dec

A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery.

Crouchet E, Bandiera S, Fujiwara N, Li S, El Saghire H, Fernández-Vaquero M, Riedl T, Sun X, Hirschfield H, Jühling F, Zhu S, Roehlen N, Ponsolles C, Heydmann L, Saviano A, Qian T, Venkatesh A, Lupberger J, Verrier ER, Sojoodi M, Oudot MA, Duong FHT, Masia R, Wei L, Thumann C, Durand SC, González-Motos V, Heide D, Hetzer J, Nakagawa S, Ono A, Song WM, Higashi T, Sanchez R, Kim RS, Bian CB, Kiani K, Croonenborghs T, Subramanian A, Chung RT, Straub BK, Schuppan D, Ankavay M, Cocquerel L, Schaeffer E, Goossens N, Koh AP, Mahajan M, Nair VD, Gunasekaran G, Schwartz ME, Bardeesy N, Shalek AK, Rozenblatt-Rosen O, Regev A, Felli E, Pessaux P, Tanabe KK, Heikenwälder M, Schuster C, Pochet N, Zeisel MB, Fuchs BC, Hoshida Y, Baumert TF, Nat Commun 2021 Sep 12 1 5525

A blood-based prognostic liver secretome signature and long-term hepatocellular carcinoma risk in advanced liver fibrosis.

Fujiwara N, Kobayashi M, Fobar AJ, Hoshida A, Marquez CA, Koneru B, Panda G, Taguri M, Qian T, Raman I, Li QZ, Hoshida H, Sezaki H, Kumada H, Tateishi R, Yokoo T, Yopp AC, Chung RT, Fuchs BC, Baumert TF, Marrero JA, Parikh ND, Zhu S, Singal AG, Hoshida Y, Med (N Y) 2021 Jul 2 7 836-850.e10

A Blood-Based Prognostic Liver Secretome Signature Predicts Long-term Risk of Hepatic Decompensation in Cirrhosis.

Fujiwara N, Fobar AJ, Raman I, Li QZ, Marrero JA, Parikh ND, Singal AG, Hoshida Y, Clin Gastroenterol Hepatol 2021 Mar

Plasma-Signature-Model for End-Stage Liver Disease Score to Predict Survival in Severe Alcoholic Hepatitis.

Fujiwara N, Trépo E, Raman I, Li QZ, Degré D, Gustot T, Moreno C, Hoshida Y, Clin Gastroenterol Hepatol 2021 Mar

MPIC: Molecular Prognostic Indicators in Cirrhosis Database for Clinical Context-Specific in Silico Prognostic Biomarker Validation.

Yip SH, Fujiwara N, Burke J, Shetler A, Peralta C, Qian T, Hoshida H, Zhu S, Hoshida Y, Front Genet 2019 10 830

Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine.

Fujiwara N, Friedman SL, Goossens N, Hoshida Y J. Hepatol. 2018 Mar 68 3 526-549

Cost-Effectiveness of Risk Score-Stratified Hepatocellular Carcinoma Screening in Patients with Cirrhosis.

Goossens N, Singal AG, King LY, Andersson KL, Fuchs BC, Besa C, Taouli B, Chung RT, Hoshida Y Clin Transl Gastroenterol 2017 Jun 8 6 e101

Molecular Liver Cancer Prevention in Cirrhosis by Organ Transcriptome Analysis and Lysophosphatidic Acid Pathway Inhibition.

Nakagawa S, Wei L, Song WM, Higashi T, Ghoshal S, Kim RS, Bian CB, Yamada S, Sun X, Venkatesh A, Goossens N, Bain G, Lauwers GY, Koh AP, El-Abtah M, Ahmad NB, Hoshida H, Erstad DJ, Gunasekaran G, Lee Y, Yu ML, Chuang WL, Dai CY, Kobayashi M, Kumada H, Beppu T, Baba H, Mahajan M, Nair VD, Lanuti M, Villanueva A, Sangiovanni A, Iavarone M, Colombo M, Llovet JM, Subramanian A, Tager AM, Friedman SL, Baumert TF, Schwarz ME, Chung RT, Tanabe KK, Zhang B, Fuchs BC, Hoshida Y Cancer Cell 2016 Dec 30 6 879-890

 Featured Books

Hepatocellular Carcinoma: Translational Precision Medicine Approaches

Hoshida (Ed.) (2019). Humana Press/Springer

Molecular Prognosis in Liver Cirrhosis. In Genomic and Precision Medicine: Infectious and Inflammatory Disease

Athuluri-Divakar, Hoshida (2019). Academic Press/Elsevier

• CPRIT Scholar in Cancer Research
  (2018)
• Elected member, American Society for Clinical Investigation (ASCI)
  (2018)
• Career Scientist Award, Irma T Hirschl Trust
  (2015-2018)
• Dr. Harold and Golden Lamport Research Award
  (2015)
• Research Fellowship, Charles A. King Trust
  (2007-2009)
• Research Resident, Viral Hepatitis Research Foundation
  (2003-2004)