Yinshi Ren, Ph.D.

• 1. Dissect the roles of marrow adipose tissue in osteonecrosis bone healing
• 2. Investigate the chronic inflammation response in osteonecrosis, and seek for potential therapeutic target for preclinical treatment
• 3. Explore the link between obesity, inflammation and osteoarthritis using transgenic animal models

 Featured Publications

HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development.

Rutkowski TP, Kohn A, Sharma D, Ren Y, Mirando AJ, Hilton MJ J. Cell. Sci. 2016 06 129 11 2145-55

NOTCH signaling in skeletal progenitors is critical for fracture repair.

Wang C, Inzana JA, Mirando AJ, Ren Y, Liu Z, Shen J, O'Keefe RJ, Awad HA, Hilton MJ J. Clin. Invest. 2016 Apr 126 4 1471-1481

Expression of the invertebrate sea urchin P16 protein into mammalian MC3T3 osteoblasts transforms and reprograms them into "osteocyte-like" cells.

Alvares K, Ren Y, Feng JQ, Veis A J. Exp. Zool. B Mol. Dev. Evol. 2016 Jan 326 1 38-46

Sclerostin antibody (Scl-Ab) improves osteomalacia phenotype in dentin matrix protein 1(Dmp1) knockout mice with little impact on serum levels of phosphorus and FGF23.

Ren Y, Han X, Jing Y, Yuan B, Ke H, Liu M, Feng JQ Matrix Biol. 2015 Dec

Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance.

Liu Z, Ren Y, Mirando AJ, Wang C, Zuscik MJ, O'Keefe RJ, Hilton MJ Osteoarthr. Cartil. 2015 Oct

Sclerostin antibody preserves the morphology and structure of osteocytes and blocks the severe skeletal deterioration after motor-complete spinal cord injury in rats.

Qin W, Li X, Peng Y, Harlow LM, Ren Y, Wu Y, Li J, Qin Y, Sun J, Zheng S, Brown T, Feng JQ, Ke HZ, Bauman WA, Cardozo CC J. Bone Miner. Res. 2015 May

Complete pulpodentin complex regeneration by modulating the stiffness of biomimetic matrix.

Qu T, Jing J, Ren Y, Ma C, Feng JQ, Yu Q, Liu X Acta Biomater 2015 Apr 16 60-70

Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model.

Ren Y, Han X, Ho SP, Harris SE, Cao Z, Economides AN, Qin C, Ke H, Liu M, Feng JQ FASEB J. 2015 Mar

A novel way to statistically analyze morphologic changes in Dmp1-null osteocytes.

Ren Y, Lin S, Jing Y, Dechow PC, Feng JQ Connect. Tissue Res. 2014 Aug 55 Suppl 1 129-33

Induced ablation of Bmp1 and Tll1 produces osteogenesis imperfecta in mice.

Muir AM, Ren Y, Butz DH, Davis NA, Blank RD, Birk DE, Lee SJ, Rowe D, Feng JQ, Greenspan DS Hum. Mol. Genet. 2014 Jun 23 12 3085-101

• Michael Philip Jagger Research Award
  Duke University (2017)
• ORS New Investigator Recognition Award
  Orthopaedic Research Society (2017)
• ASBMR President's Award
  American Association of Bone and Mineral Research (2015)
• AAA graduate student platform Award
  American Association of Anatomists (2013)
• ICCBMT Young Investigator Award
  International Conference on the Chemistry and Biology of Mineralized Tissues (2013)
• Hatton Award
  American Association for Dental Research (2012)

• American Association of Anatomists (2014)
• American Association of Dental Research (2012)
• American Society for Bone and Mineral Research (2011)
• Orthopaedic Research Society (2017)