Yinshi Ren, Ph.D.

• 1. Dissect the roles of marrow adipose tissue in osteonecrosis bone healing
• 2. Investigate the chronic inflammation response in osteonecrosis, and seek for potential therapeutic target for preclinical treatment
• 3. Explore the link between obesity, inflammation and osteoarthritis using transgenic animal models

 Featured Publications

Obesity impairs revascularization and bone healing in a mouse model of osteonecrosis.

Deng Z, Aguirre-Flores M, Kim HKW, Ren Y, J Orthop Res 2023 Nov

Local BMP2 hydrogel therapy for robust bone regeneration in a porcine model of Legg-Calvé-Perthes disease.

Ma C, Park MS, Alves do Monte F, Gokani V, Aruwajoye OO, Ren Y, Liu X, Kim HKW, NPJ Regen Med 2023 Sep 8 1 50

Glutathione limits RUNX2 oxidation and degradation to regulate bone formation.

Hu G, Yu Y, Sharma D, Pruett-Miller SM, Ren Y, Zhang GF, Karner CM, JCI Insight 2023 Jul

Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget's Disease of Bone.

Rabjohns EM, Rampersad RR, Ghosh A, Hurst K, Eudy AM, Brozowski JM, Lee HH, Ren Y, Mirando A, Gladman J, Bowser JL, Berg K, Wani S, Ralston SH, Hilton MJ, Tarrant TK, Cells 2023 Mar 12 7

Local Administration of Bone Morphogenetic Protein-2 Using a Hydrogel Carrier for Robust Bone Regeneration in a Large Animal Model of Legg-Calvé-Perthes disease.

Kim H, Ma C, Park M, Monte F, Gokani V, Aruwajoye O, Ren Y, Liu X, Res Sq 2023 Jan

Interleukin-6 signaling mediates cartilage degradation and pain in posttraumatic osteoarthritis in a sex-specific manner.

Liao Y, Ren Y, Luo X, Mirando AJ, Long JT, Leinroth A, Ji RR, Hilton MJ, Sci Signal 2022 Jul 15 744 eabn7082

Hypertrophic chondrocytes serve as a reservoir for marrow associated skeletal stem and progenitor cells, osteoblasts, and adipocytes during skeletal development.

Long JT, Leinroth A, Liao Y, Ren Y, Mirando AJ, Nguyen T, Guo W, Sharma D, Rouse D, Wu C, Cheah KSE, Karner CM, Hilton MJ, Elife 2022 Feb 11

G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation.

Brozowski JM, Timoshchenko RG, Serafin DS, Allyn B, Koontz J, Rabjohns EM, Rampersad RR, Ren Y, Eudy AM, Harris TF, Abraham D, Mattox D, Rubin CT, Hilton MJ, Rubin J, Allbritton NL, Billard MJ, Tarrant TK, Stem Cell Res Ther 2022 Jan 13 1 37

Development of a murine model of ischemic osteonecrosis to study the effects of aging on bone repair.

Yamaguchi R, Kamiya N, Kuroyanagi G, Ren Y, Kim HKW, J Orthop Res 2021 Dec 39 12 2663-2670

Damage Associated Molecular Patterns in Necrotic Femoral Head Inhibit Osteogenesis and Promote Fibrogenesis of Mesenchymal Stem Cells.

Deng Z, Ren Y, Park MS, Kim HKW, Bone 2021 Sep 116215

• Michael Philip Jagger Research Award
  Duke University (2017)
• ORS New Investigator Recognition Award
  Orthopaedic Research Society (2017)
• ASBMR President's Award
  American Association of Bone and Mineral Research (2015)
• AAA graduate student platform Award
  American Association of Anatomists (2013)
• ICCBMT Young Investigator Award
  International Conference on the Chemistry and Biology of Mineralized Tissues (2013)
• Hatton Award
  American Association for Dental Research (2012)

• American Association of Anatomists (2014)
• American Association of Dental Research (2012)
• American Society for Bone and Mineral Research (2011)
• Orthopaedic Research Society (2017)