Jin Ye, Ph.D. Titles and Appointments Professor Schools Medical School | Graduate School Departments Molecular Genetics Graduate Programs Biological Chemistry, Cell and Molecular Biology Biography Download Curriculum Vitae Jin Ye received a MS degree in Biochemistry from Case Western Reserve University in 1995. He was mentored by Nobel laureates Michael Brown and Joseph Goldstein at UT Southwestern, obtaining his PhD in Cell Regulation in 2000, and continuing in a postdoctoral fellowship from 2000 to 2004. He joined the faculty at the UT Southwestern Medical Center in 2004 as an Assistant Professor. He was promoted to Professor in 2022. Dr. Ye’s research interests are to understand the mechanism of diseases caused by abnormal lipid metabolism. Currently, his lab is investigating how ferroptosis, a cell death pathway caused by iron-catalyzed peroxidation of polyunsaturated fatty acids, contributes to development of human diseases such as alcoholic liver disease. His lab has employed multiple approaches ranging from in vitro biochemical assays to mouse models of the human diseases to develop novel treatments of diseases caused by ferroptosis. Education Graduate School Case Western Reserve Univ (1995), Biochemistry Graduate School Univ of Tx Southwestern Med Ct (2000), Cell Regulation Research Interest Cell biological and biochemical mechanism of ferroptosis Development of novel therapies to treat diseases caused by ferroptosis such as alcoholic liver disease Regulation of lipid metabolism Publications Featured Publications Protection against ferroptosis through maintaining homeostasis of docosahexaenoate-containing phospholipids. Deng Y, Vale G, Liang Y, Cui S, Xu S, McDonald JG, Ye J, Mol Cell 2025 Sep 85 18 3474-3485.e5 Advanced alcoholic liver disease driven by a pro-ferroptotic diet Liang Y, Xu Y, Virostek M, Johnson A, Evers B, Deng Y, Meng Y, McDonald JG, Scherer PE, Cui S, Ye J. J Lipid Res 2025 5H7c: A rabbit monoclonal antibody detecting ferroptotic cells. Cui S, Donnelly L, Ghai A, Achilefu S, Ye J, Mol Cell 2024 Dec 84 23 4471-4472 Identification of hyperoxidized PRDX3 as a ferroptosis marker reveals ferroptotic damage in chronic liver diseases. Cui S, Ghai A, Deng Y, Li S, Zhang R, Egbulefu C, Liang G, Achilefu S, Ye J, Mol Cell 2023 Oct FAF1 blocks ferroptosis by inhibiting peroxidation of polyunsaturated fatty acids. Cui S, Simmons G, Vale G, Deng Y, Kim J, Kim H, Zhang R, McDonald JG, Ye J, Proc Natl Acad Sci U S A 2022 Apr 119 17 e2107189119 Ferroptosis: The Demise of Cells Through Phospholipid Peroxidation. Cui S, Ye J, Adv Sci (Weinh) 2026 Mar e24387 MAFLD: a ferroptotic disease. Cui S, Ye J, Trends Mol Med 2025 Sep 7-Dehydrocholesterol: A sterol shield against an iron sword. Cui S, Ye J, Mol Cell 2024 Apr 84 7 1183-1185 Topological regulation of a transmembrane protein by luminal-to-cytosolic retrotranslocation of glycosylated sequence. Wang J, Han S, Ye J, Cell Rep 2023 Mar 42 4 112311 Identification of TRAMs as Sphingolipid-Binding Proteins Using a Photoactivatable and Clickable Short Chain Ceramide Analog. Deng Y, You L, Lu Y, Han S, Wang J, Vicas N, Chen C, Ye J, J Biol Chem 2021 Nov 101415 Results 1-10 of 35 1 2 3 4 Next Last Books Featured Books Regulated Intramembrane Proteolysis. In Encyclopedia of Biological Chemistry, 2nd edition Jin Ye (2013). Oxford, United Kingdom, Elsevier Inc. Regulation of Cholesterol and Fatty Acid Metabolism. In Discoveries in Modern Science: Exploration, Invention, Technology Jin Ye (2015). Farmington Hills, MI, Gale Ferroptosis and NADPH Oxidases. In E. Pick (Ed,), Advances in NADPH Oxidases Research, From Molecules to Diseases Cui S, Ye J (2026). Gewerbestrasse, Switzerland, Springer Nature. Detecting ferroptotic cells using an antibody against hyperoxidized PRDX3. In Methods in Cell Biology Sun, P., Yin, W., Sheng, M., Meng, Y., Han, K., Li, Z., Xu, Y., Cui, S., and Ye, J (2006). Oxford, United Kingdom, Elsevier Inc. Professional Associations/Affiliations Department of Molecular Genetics (2004) Simmons Comprehensive Cancer Center (2016)
