Medical School
University of Tsukuba , Medicine
Graduate School
University of Tsukuba (1988), Pharmacology

Research Interest

  • Molecular genetics of sleep/wake regulation
  • Orphan GPCRs and their neuropeptide ligands


Featured Publications LegendFeatured Publications

Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice.
Chang I, Bramall AN, Baynash AG, Rattner A, Rakheja D, Post M, Joza S, McKerlie C, Stewart DJ, McInnes RR, Yanagisawa M J. Clin. Invest. 2013 Jun 123 6 2643-53
Behavioral and biochemical dissociation of arousal and homeostatic sleep need influenced by prior wakeful experience in mice.
Suzuki A, Sinton CM, Greene RW, Yanagisawa M Proc. Natl. Acad. Sci. U.S.A. 2013 May
Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep.
Funato H, Sato M, Sinton CM, Gautron L, Williams SC, Skach A, Elmquist JK, Skoultchi AI, Yanagisawa M Proc. Natl. Acad. Sci. U.S.A. 2010 Oct 107 42 18155-60
Low blood pressure in endothelial cell-specific endothelin 1 knockout mice.
Kisanuki YY, Emoto N, Ohuchi T, Widyantoro B, Yagi K, Nakayama K, Kedzierski RM, Hammer RE, Yanagisawa H, Williams SC, Richardson JA, Suzuki T, Yanagisawa M Hypertension 2010 Jul 56 1 121-8
Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivity.
Funato H, Tsai AL, Willie JT, Kisanuki Y, Williams SC, Sakurai T, Yanagisawa M. Cell Metab. January 2009 9 64-76
Endothelin: 20 years from discovery to therapy.
Barton M, Yanagisawa M. Can J. Physiol. Pharmacol. 2008 86 485-98
An essential role for orexins in emergence from general anesthesia.
Kelz MB, Sun Y, Chen J, Cheng Meng Q, Moore JT, Veasey SC, Dixon S, Thornton M, Funato H, Yanagisawa M. Proc. Natl. Acad. Sci. USA 2008 105 1309-14
Reduced expression of the endothelin receptor type B gene in piebald mice caused by insertion of a retroposon-like element in intron 1.
Yamada T, Ohtani S, Sakurai T, Tsuji T, Kunieda T, Yanagisawa M. J. Biol. Chem. 2006 281 10799-807
The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker.
Mieda M, Williams SC, Richardson JA, Tanaka K, Yanagisawa M. Proc. Natl. Acad. Sci. USA 2006 103 12150-5

Honors & Awards

  • Bristol-Myers Squibb Achievement Award in Cardiovascular Research
  • Elected Member, National Academy of Sciences
  • The Amgen Award, American Society of Biochemistry and Molecular Biology
  • The Kilby Award, The Kilby Award Foundation
  • The Novartis Award, American Heart Association

Professional Associations/Affiliations

  • Investigator, Howard Hughes Medical Institute