Education

Medical School
University of Tsukuba , Medicine
Graduate School
University of Tsukuba (1988), Pharmacology

Research Interest

  • Molecular genetics of sleep/wake regulation
  • Orphan GPCRs and their neuropeptide ligands

Publications

Featured Publications LegendFeatured Publications

[Development of a Therapeutic Drug for Narcolepsy].
Irukayama-Tomobe Y, Yanagisawa M Brain Nerve 2018 Nov 70 11 1255-1263
A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice.
Honda T, Fujiyama T, Miyoshi C, Ikkyu A, Hotta-Hirashima N, Kanno S, Mizuno S, Sugiyama F, Takahashi S, Funato H, Yanagisawa M Proc. Natl. Acad. Sci. U.S.A. 2018 Sep
Continuous intrathecal orexin delivery inhibits cataplexy in a murine model of narcolepsy.
Kaushik MK, Aritake K, Imanishi A, Kanbayashi T, Ichikawa T, Shimizu T, Urade Y, Yanagisawa M Proc. Natl. Acad. Sci. U.S.A. 2018 May
Ablation of Central Serotonergic Neurons Decreased REM Sleep and Attenuated Arousal Response.
Iwasaki K, Komiya H, Kakizaki M, Miyoshi C, Abe M, Sakimura K, Funato H, Yanagisawa M Front Neurosci 2018 12 535
Sleep/wakefulness behaviors in mice during pregnancy and pregnancy-associated hypertensive mice.
Komiya H, Miyoshi C, Iwasaki K, Hotta-Hirashima N, Ikkyu A, Kanno S, Honda T, Gosho M, Hamada H, Satoh T, Fukamizu A, Funato H, Yanagisawa M Sleep 2017 Dec
Anatomical and Electrophysiological Development of the Hypothalamic Orexin Neurons from Embryos to Neonates.
Ogawa Y, Kanda T, Vogt K, Yanagisawa M J. Comp. Neurol. 2017 Jun
Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models.
Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M Proc. Natl. Acad. Sci. U.S.A. 2017 May 114 22 5731-5736

Honors & Awards

  • Bristol-Myers Squibb Achievement Award in Cardiovascular Research
    (2003)
  • Elected Member, National Academy of Sciences
    (2003)
  • The Amgen Award, American Society of Biochemistry and Molecular Biology
    (1999)
  • The Kilby Award, The Kilby Award Foundation
    (1998)
  • The Novartis Award, American Heart Association
    (1998)

Professional Associations/Affiliations

  • Investigator, Howard Hughes Medical Institute