Glen Liszczak, Ph.D.
Titles and Appointments
Assistant Professor
- Endowed Title
- Virginia Murchison Linthicum Scholar in Medical Research
- School
- Medical School
- Department
- Biochemistry
- Graduate Programs
- Biological Chemistry
Glen Liszczak is an Assistant Professor in the Department of Biochemistry at the University of Texas Southwestern Medical Center. He received his B.S. in Chemistry and Biology from Ramapo College of New Jersey and his Ph.D. in Chemistry from the University of Pennsylvania at the Wistar Institute under the supervision of Dr. Ronen Marmorstein. As a graduate student, Glen used X-ray crystallography and other biochemical and biophysical tools to determine the molecular basis for catalysis and substrate specificity exhibited by various protein-modifying enzymes.
In 2013, Glen joined the laboratory of Professor Tom Muir as a postdoctoral fellow at Princeton University where he employed a wide array of chemical biology techniques, including protein semisynthesis and intracellular protein delivery, to delineate epigenetic mechanisms and their misregulation in cancer. During his postdoctoral studies, Glen combined protein semi-synthesis with high-throughput biochemistry and cellular biology to study proteins that interact with the genome and regulate gene expression.
In 2018, Glen joined the faculty at UTSW as an Endowed Scholar. His lab integrates chemical and biological approaches to understand the biochemical mechanisms through which enigmatic mutations and aberrant protein post-translational modification cascades lead to disease phenotypes. Current research topics in the lab include epigenetics, chromatin structure, transcriptional regulation, protein and nucleic acid trafficking, and protein post-translational modifications such as mono- and poly-ADP-ribosylation. Our work has uncovered key mechanisms underlying cancer development, neurodegeneration, and other developmental abnormalities.
Throughout his career Glen has been the recipient of numerous awards for his research, including the Dr. Monica H.M. Shander Memorial Fellowship, a Ruth L. Kirschstein National Research Service Award, a Cancer Prevention Research Institute of Texas (CPRIT) Recruitment of First-Time, Tenure-Track Faculty Member Award, a UT System Rising STARs Award, and an American Heart Association Career Development Award.
Featured Publications