Xiao-Song Xie, Ph.D. - Faculty Profile

Biography

Research and Professional Experience

1980-1985 Graduate Research Assistant, Department of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY PhD Thesis Advisor: Efraim Racker, MD

1985-1987 Research Assistant Professor Dept. Internal Medicine, UT Southwestern Medical Center

1987-1990 Assistant Professor, Department of Physiology, UT Southwestern Medical Center

1987-present Member of Graduate Faculty, Graduate Program of Biological Chemistry, UT Southwestern Graduate school of Biomedical Sciences

1990-1998 Associate Professor of Internal Medicine and Physiology, Department of Internal Medicine, UT Southwestern

1998-present Professor of Internal Medicine, Department of Internal Medicine, UT Southwestern

2001-present Professor of Internal Medicine, McDermott Center for Human Growth and Development, UT Southwestern

Research Projects Ongoing or Completed During the last Three years:

Structure and Function of ABCG5 and ABCG8.

The long-term goal of this project is to determine the structure and function of this important ABC transport system and to understand the mechanism by which this ABC transporter translocates sterols across membranes. The project in the current phase is focusing on the role of intestinal expressed ABCG5/ABCG8 and the high-resolution structure of it.

The Structure and Function of Mammalian V-type proton Translocation ATPases.

The long-term goal of this project is to determine the structural basis of the function and regulation of V-type proton pumps. The project characterizes the catalytic center and a regulatory component of the V-type proton pump of clathrin-coated vesicles and studies the isoform structure of the major subunits in its membrane domain to determine the structural basis for the regulation of this pump

Lipid asymmetry in plasma membrane and Apoptosis-induced PS exposure

The long-term goal of this project is to elucidate the mechanism by which the maintenance of lipid asymmetry in plasma membrane and PS exposure during apoptosis are regulated.

Education

Research Interest

Publications

Featured Publications

Structure of the 116-kDa polypeptide of the clathrin-coated vesicle/synaptic vesicle proton pump.: Perin MS, Fried VA, Stone DK, Xie XS, Südhof TC J. Biol. Chem. 1991 Feb 266 6 3877-81
Structural properties of vacuolar proton pumps.: Stone DK, Crider BP, Xie XS Kidney Int. 1990 Oct 38 4 649-53
Aldosterone and urinary acidification.: Stone DK, Crider BP, Xie XS Semin. Nephrol. 1990 Jul 10 4 375-9
Structure of vacuolar proton pumps.: Stone DK, Crider BP, Xie XS Semin. Nephrol. 1990 Mar 10 2 159-65
Isolation and reconstitution of the chloride transporter of clathrin-coated vesicles.: Xie XS, Crider BP, Stone DK J. Biol. Chem. 1989 Nov 264 32 18870-3
Vacuolar proton pumps.: Stone DK, Crider BP, Südhof TC, Xie XS J. Bioenerg. Biomembr. 1989 Oct 21 5 605-20
Human endomembrane H+ pump strongly resembles the ATP-synthetase of Archaebacteria.: Südhof TC, Fried VA, Stone DK, Johnston PA, Xie XS Proc. Natl. Acad. Sci. U.S.A. 1989 Aug 86 16 6067-71
Purification of a vanadate-sensitive ATPase from clathrin-coated vesicles of bovine brain.: Xie XS, Stone DK, Racker E J. Biol. Chem. 1989 Jan 264 3 1710-4
Partial resolution and reconstitution of the subunits of the clathrin-coated vesicle proton ATPase responsible for Ca2+-activated ATP hydrolysis.: Xie XS, Stone DK J. Biol. Chem. 1988 Jul 263 20 9859-67
Proton translocating ATPases: issues in structure and function.: Stone DK, Xie XS Kidney Int. 1988 Apr 33 4 767-74

Professional Associations/Affiliations