Research and Professional Experience

1980-1985 Graduate Research Assistant, Department of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY  PhD Thesis Advisor: Efraim Racker, MD

1985-1987 Research Assistant Professor Dept. Internal Medicine, UT Southwestern Medical Center

1987-1990 Assistant Professor, Department of Physiology, UT Southwestern Medical Center

1987-present Member of Graduate Faculty, Graduate Program of Biological Chemistry, UT Southwestern Graduate school of Biomedical Sciences

1990-1998 Associate Professor of Internal Medicine and Physiology, Department of Internal Medicine, UT Southwestern

1998-present Professor of Internal Medicine, Department of Internal Medicine, UT Southwestern

2001-present Professor of Internal Medicine, McDermott Center for Human Growth and Development, UT Southwestern

Research Projects Ongoing or Completed During the last Three years:

  1. Structure and Function of ABCG5 and ABCG8.

 The long-term goal of this project is to determine the structure and function of this important ABC transport system and to understand the mechanism by which this ABC transporter translocates sterols across membranes.  The project in the current phase is focusing on the role of intestinal expressed ABCG5/ABCG8 and the high-resolution structure of it.

  1. The Structure and Function of Mammalian V-type proton Translocation ATPases.

The long-term goal of this project is to determine the structural basis of the function and regulation of V-type proton pumps. The project characterizes the catalytic center and a regulatory component of the V-type proton pump of clathrin-coated vesicles and studies the isoform structure of the major subunits in its membrane domain to determine the structural basis for the regulation of this pump

  1. Lipid asymmetry in plasma membrane and Apoptosis-induced PS exposure

The long-term goal of this project is to elucidate the mechanism by which the maintenance of lipid asymmetry in plasma membrane and PS exposure during apoptosis are regulated.


Beijing University - China (1975)
Beijing University - China (1975)
Graduate School
Cornell University (1985)

Research Interest

  • Biochemistry of ABC transporters-ABCG5 and ABCG8.
  • Structure and function of V-type Proton translocating ATPase.


Featured Publications LegendFeatured Publications

Incomplete Distal Renal Tubular Acidosis from a Heterozygous Mutation of the V-ATPase B1 Subunit.
Zhang J, Fuster DG, Cameron MA, QuiƱones H, Griffith C, Xie XS, Moe OW Am. J. Physiol. Renal Physiol. 2014 Aug
Palmerolide macrolides from the Antarctic tunicate Synoicum adareanum.
Noguez JH, Diyabalanage TK, Miyata Y, Xie XS, Valeriote FA, Amsler CD, McClintock JB, Baker BJ Bioorganic & medicinal chemistry 2011 Jun
Purification and reconstitution of sterol transfer by native mouse ABCG5 and ABCG8.
Wang J, Zhang DW, Lei Y, Xu F, Cohen JC, Hobbs HH, Xie XS Biochemistry 2008 May 47 18 5194-204
The vacuolar-ATPase B1 subunit in distal tubular acidosis: novel mutations and mechanisms for dysfunction.
Fuster DG, Zhang J, Xie XS, Moe OW Kidney Int. 2008 May 73 10 1151-8
Three-dimensional reconstruction of bovine brain V-ATPase by cryo-electron microscopy and single particle analysis
Marco Gregorini, Jin Wang, Xiao-Song Xie, Ronald, Milligan, Andreas, Engel Journal of Structural Biology June 2007 Vol. 158 pp.445-454
C. elegans mitochondrial factor WAH-1 promotes PS externalization in apoptotic cells through phospholipid scramblase SCRM-1
Xiaochen Wang, Jin Wang, Keiko Gengyo-Ando, Lichan Gu, Chen-Ling sun, Chonglin Yang, Yong Shi, TetsuoKobayashi, Yigong Shi, Shohei Mitani, Xiao-Song Xie, and Ding Xue Nature Cell Biology May 2007 Vol. 9 pp.541-549
Sterol Transfer by ABCG5 and ABCG8
Jin Wang, Fang Sun, Da-wei Zhang, Yongming Ma, Fang Xu, Jitendra belani, Jonathan Cohen, Helen, Hobbs, and Xiao-Song Xie Journal of Biologicla Chemistry September 2006 Vol. 281 pp.27894-27904

Professional Associations/Affiliations

  • American Society for Biochemistry and Molecular Biology