Ru-Feng Wu, M.D., Ph.D. Assistant Professor School Medical School Department Internal Medicine Biography Ru-Feng Wu, M.D., Ph.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of the Division of Pulmonary and Critical Care Medicine. Originally from China, Dr. Wu earned his medical degree and a master's degree in toxicology at China Medical University. He earned his doctorate in biochemistry at Kagawa Medical School in Japan. He completed postdoctoral fellowships in biochemistry and internal medicine at UT Southwestern Medical Center. Dr. Wu joined the UT Southwestern faculty in 2008. Education Medical School China Medical University - Chi (1984) Graduate School Kagawa Medical School - ? (1995) Research Interest Cell signal transduction HIV Tat and Endothelial Cell Dysfunction Oxidant signaling pathways Publications Featured Publications Porcine FAD-containing monooxygenase metabolizes lidocaine, bupivacaine and propranolol in vitro Wu, R.F.,(Corresponding author) Liao, C.X., Tomita, S., Ichikawa, Y., Terada, L.S. Life Sci July 2004 75(8) 1011-9 Human immunodeficiciency virus type 1 Tat regulates endothelial cell actin cytoskeletal dynamics through PAK1 activation and oxidant production Wu, R.F., Y. Gu, Y.C. Xu, S. Mitola, F. Bussolino, and L.S. Terada J. Virol. January 2004 78:(2) 779-789 Identification of Translin/Trax complex as a glucose response element binding protein in liver Wu, R.F.,(Corresponding author)Osatomi, K., Trerada, L.S., Uyeda, K Biochim Biophys Acta December 2003 1624(1-3) 29-35 VEGF causes translocation of p47phox to membrane ruffles through WAVE1 Wu, R.F., Y. Gu, Y.C. Xu, F.E. Nwariaku, and L.S. Terada. J. Biol. Chem. September 2003 278 (38) 36830-36840 Mutations in the charged residues of the amino terminus of rat liver fructose 6-phosphate,2-kinase: Fructose 2,6-bisphosphatase: Effects on regulation Wu RF, Uyeda K ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS November 1999 371 (1): 15-23 Nox4-derived H2O2 mediates endoplasmic reticulum signaling through local Ras activation Wu RF, Ma Z and Terada LS Mol Cell Biol July 2010 14 (30) 3553-3568 Ras and Nox: linked signaling networks? Wu RF and Terada LS Free Radical Biology & Medicine November 2009 47 (9) 1278-81 HIV1 Tat activates dual Nox pathways leading to independent activation of ERK and JNK MAP kinases. Wu RF, Ma Z, Myers DP, et al. JOURNAL OF BIOLOGICAL CHEMISTRY December 2007 282 (52) 37412-37419 Oxidative modification of protein tyrosine phosphatases. Wu, R.F., and Terada, L.S., Sci STKE April 2006 2006 (332) P12 Subcellular targeting of oxidants during endothelial cell migration Wu, R.F., Y.C. Xu, Z. Ma, F.E. Nwariaku, G.A, Sarosi, and L.S. Terada J. Cell Biol December 2005 171(5) 893-904 Results 1-10 of 10 1 Honors & Awards Scholar in Scientific Researchministry of education, science and culture, Japan (1991)
