Zhikai Chi, M.D., Ph.D. - Faculty Profile

Biography

Dr. Chi grew up in Beijing China. He attended undergraduate study at Peking University and medical school at Peking Union Medical College. He later joined Drs. Valina and Ted Dawson’s laboratory at the Johns Hopkins University School of Medicine, where he studied the molecular mechanisms of neuroprotection and neurodevelopment. His Ph.D. works were published in high-profile journals including Cell, Development Cell, Cell reports, Nature Medicine, and Proceedings of the National Academy of Sciences. Dr. Chi subsequently trained in anatomic and clinical pathology residency at Indiana University School of Medicine, and gastrointestinal and liver pathology fellowship at Cedars Sinai Medical Center. He joined the faculty as an Assistant Professor at UTSW in July 2018.

Dr. Chi’s current research interests include clinicopathological, immunohistochemical, and molecular characterization of gastrointestinal, pancreatic, and liver neoplasm as well as inflammatory diseases. He also actively engages in collaborative research projects with basic scientists interested in gastrointestinal and pancreatic diseases. Dr. Chi currently serves as co-investigators for multiple NIH funded studies and always looks forward to more collaborating opportunities.

Education

Other Post Graduate Training: John Hopkins University School of Medicine
Medical School: Peking Union Medical College (2003)
Graduate School: Johns Hopkins University School of Medicine (2009)
Fellowship: Johns Hopkins Hospital (2013), Post Doctoral
Residency: Indiana University School of Medicine (2017), Pathology
Fellowship: Cedars Sinai Medical Center (2018), Gastrointestinal & Liver Pathology

Research Interest

Clinicopathologic characterization of gastrointestinal tract inflammatory diseases such as inflammatory bowel disease and microscopic colitis.
Clinicopathologic characterization of gastrointestinal tract, liver, and pancreatic tumors, with a current emphasis on esophageal squamous cell carcinoma and pancreatic ductal adenocarcinoma.

Publications

Featured Publications

PD-L1 (22C3) expression and prognostic implications in esophageal squamous cell carcinoma.: Chi Z, Peng L, Karamchandani DM, Xu J, Ann Diagn Pathol 2024 Nov 74 152394
A critical assessment of using ChatGPT for extracting structured data from clinical notes.: Huang J, Yang DM, Rong R, Nezafati K, Treager C, Chi Z, Wang S, Cheng X, Guo Y, Klesse LJ, Xiao G, Peterson ED, Zhan X, Xie Y, NPJ Digit Med 2024 May 7 1 106
INSM1 is a useful neuroendocrine marker to differentiate pancreatic serous cystadenoma from pancreatic well-differentiated neuroendocrine tumors in cytology and surgical specimens.: Chi Z, Xu J, Karamchandani DM, Peng L, Ann Diagn Pathol 2024 Apr 71 152304
Esophageal carcinoma with SMARCA4 mutation: a narrative review for this rare entity.: Xu J, Chi Z, Transl Gastroenterol Hepatol 2024 9 24
Deep learning of cell spatial organizations identifies clinically relevant insights in tissue images.: Wang S, Rong R, Zhou Q, Yang DM, Zhang X, Zhan X, Bishop J, Chi Z, Wilhelm CJ, Zhang S, Pickering CR, Kris MG, Minna J, Xie Y, Xiao G, Nat Commun 2023 Dec 14 1 7872
Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth.: Jeong MH, Urquhart G, Lewis C, Chi Z, Jewell JL, JCI Insight 2023 Jul 8 13
Pax8 as a useful adjunct marker to differentiate pancreatic serous cystadenoma from clear cell renal cell carcinoma in both cytologic and surgical specimens.: Chi Z, Xu J, Karamchandani DM, Peng L, Diagn Pathol 2023 Apr 18 1 54
GATA3 positivity is associated with poor prognosis in patients with oesophageal squamous cell carcinoma.: Chi Z, Balani J, Gopal P, Hammer S, Xu J, Peng L, J Clin Pathol 2022 Jan
The Use of Intraoperative Frozen Sections in Guiding the Extent of Pancreatic Resections for Intraductal Papillary Mucinous Neoplasms: A Single Institution Experience and Review of the Literature.: Chi Z, Dhall D, Mertens R, Pancreas 2022 Jan 51 1 63-74
Variations of P40 and P63 Immunostains in Different Grades of Esophageal Squamous Cell Carcinoma: A Potential Diagnostic Pitfall.: Chi Z, Balani J, Gopal P, Peng L, Hammer S, Appl Immunohistochem Mol Morphol 2021 May