Carol Wise, Ph.D.

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Dr. Carol Wise is Director of Basic Research at Texas Scottish Rite Hospital for Children and Professor in the McDermott Center for Human Growth and Development and departments of Orthopaedic Surgery and Pediatrics at UTSW. Originally from Texas, she received her undergraduate degree in chemistry from Texas A&M University and her doctorate degree in biochemistry from The University of Texas Southwestern Medical Center at Dallas. She completed postdoctoral fellowships in human molecular genetics with James Lupski at Baylor College of Medicine in Houston and with Michael Lovett at The University of Texas Southwestern Medical Center at Dallas. Dr. Wise is a founding member and chair of the International Consortium for Spinal Genetics, Development, and Disease. She also co-directs the TSRHC GOOD for KIDs program aimed at solving rare debilitating musculoskeletal diseases in children using next-generation genomic methods. Dr. Wise’s laboratory hosts the TSRHC Scoliosis Biobank and the U.S. DNA and Cell repository for the Primordial Registry, a joint effort with Dr. Michael Bober at A. I. duPont Hospital for Children. Dr. Wise leads NIH-funded projects focused on mechanistic understanding of adolescent idiopathic scoliosis, the most common musculoskeletal disorder in children, and on earlier onset forms. 

Undergraduate

Texas A & M University (1985), Chemistry

Graduate School

UT Southwestern Medical Center (1991), Biochemistry

• Genetic and Biochemical Causes of Pediatric Musculoskeletal Disorders
• Genetics Risk Factors for Idiopathic Scoliosis

Featured Publications

Association of an estrogen-sensitive Pax1-Col11a1-Mmp3 signaling axis with adolescent idiopathic scoliosis.

Yu H, Khanshour AM, Ushiki A, Otomo N, Koike Y, Einarsdottir E, Fan Y, Antunes L, Kidane YH, Cornelia R, Sheng R, Zhang Y, Pei J, Grishin NV, Evers BM, Yin Cheung JP, Herring JA, Terao C, Song YQ, Gurnett CA, Gerdhem P, Ikegawa S, Rios JJ, Ahituv N, Wise CA, bioRxiv 2023 May

Molecular Dissection of Somatic Skeletal Disease in Neurofibromatosis Type 1.

Paria N, Khalid A, Shen B, Lemoine B, Chan J, Kidane YH, Oxendine I, Cornelia R, Wise CA, Rios JJ, J Bone Miner Res 2023 Feb 38 2 288-299

Saturation mutagenesis defines novel mouse models of severe spine deformity.

Rios JJ, Denton K, Yu H, Manickam K, Garner S, Russell J, Ludwig S, Rosenfeld JA, Liu P, Munch J, Sucato DJ, Beutler B, Wise CA, Dis Model Mech 2021 Jun

The cartilage matrisome in adolescent idiopathic scoliosis.

Wise CA, Sepich D, Ushiki A, Khanshour AM, Kidane YH, Makki N, Gurnett CA, Gray RS, Rios JJ, Ahituv N, Solnica-Krezel L, Bone Res 2020 Mar 8 1 13

Genome-wide meta-analysis and replication studies in multiple ethnicities identify novel adolescent idiopathic scoliosis susceptibility loci.

Khanshour AM, Kou I, Fan Y, Einarsdottir E, Makki N, Kidane YH, Kere J, Grauers A, Johnson TA, Paria N, Patel C, Singhania R, Kamiya N, Takeda K, Otomo N, Watanabe K, Luk KDK, Cheung KMC, Herring JA, Rios JJ, Ahituv N, Gerdhem P, Gurnett CA, Song YQ, Ikegawa S, Wise CA Hum. Mol. Genet. 2018 11 27 22 3986-3998

Mutations Preventing Regulated Exon Skipping in MET Cause Osteofibrous Dysplasia.

Gray MJ, Kannu P, Sharma S, Neyt C, Zhang D, Paria N, Daniel PB, Whetstone H, Sprenger HG, Hammerschmidt P, Weng A, Dupuis L, Jobling R, Mendoza-Londono R, Dray M, Su P, Wilson MJ, Kapur RP, McCarthy EF, Alman BA, Howard A, Somers GR, Marshall CR, Manners S, Flanagan AM, Rathjen KE, Karol LA, Crawford H, Markie DM, Rios JJ, Wise CA, Robertson SP Am. J. Hum. Genet. 2015 Dec 97 6 837-47

A PAX1 enhancer locus is associated with susceptibility to idiopathic scoliosis in females.

Sharma S, Londono D, Eckalbar WL, Gao X, Zhang D, Mauldin K, Kou I, Takahashi A, Matsumoto M, Kamiya N, Murphy KK, Cornelia R, Herring JA, Burns D, Ahituv N, Ikegawa S, Gordon D, Wise CA Nat Commun 2015 6 6452

Summary of the first inaugural joint meeting of the International Consortium for scoliosis genetics and the International Consortium for vertebral anomalies and scoliosis, March 16-18, 2017, Dallas, Texas.

Giampietro PF, Pourquie O, Raggio C, Ikegawa S, Turnpenny PD, Gray R, Dunwoodie SL, Gurnett CA, Alman B, Cheung K, Kusumi K, Hadley-Miller N, Wise CA Am. J. Med. Genet. A 2017 Nov

Neurofibromin Deficiency-Associated Transcriptional Dysregulation Suggests a Novel Therapy for Tibial Pseudoarthrosis in NF1.

Paria N, Cho TJ, Choi IH, Kamiya N, Kayembe K, Mao R, Margraf RL, Obermosser G, Oxendine I, Sant DW, Song MH, Stevenson DA, Viskochil DH, Wise CA, Kim HK, Rios JJ J. Bone Miner. Res. 2014 Jun

ptk7 mutant zebrafish models of congenital and idiopathic scoliosis implicate dysregulated Wnt signalling in disease.

Hayes M, Gao X, Yu LX, Paria N, Henkelman RM, Wise CA, Ciruna B Nat Commun 2014 5 4777

 Featured Books

Molecular Genetics of Pediatric Orthopaedic Disorders

(Ed.) (2014). New York, New York, Springer

• Russell A. Hibbs Basic Science Award, Scoliosis Research Society
  (2014)
• Russell A. Hibbs Basic Science Award, Scoliosis Research Society
  (2012)
• Distinguished Service Award, Texas Genetics Society
  (2011)
• Community Builder Award, Brooklyn Lodge
  (2010)
• Anson Jones Award, Ft. Worth Scottish Rite Foundation
  (2009)
• Community Builder Award, John L. DeGrozier Lodge
  (2009)
• Forney High School Hall of Honor
  (2009)
• Texas Trailblazer, The Family Place
  (2008)
• YWCA Centennial Award
  (2007)

• Scottish Rite Hospital Children (1996)
• University of Texas Southwestern Medical Center (1997)