Carol Wise, Ph.D. Titles and Appointments Professor Schools Medical School | Graduate School Departments Eugene McDermott Center for Human Growth and Development | Orthopaedic Surgery | Pediatrics Graduate Programs Genetics, Development and Disease Biography Download Curriculum Vitae Dr. Carol Wise is Director of Basic Research at Texas Scottish Rite Hospital for Children and Professor in the McDermott Center for Human Growth and Development and departments of Orthopaedic Surgery and Pediatrics at UTSW. Originally from Texas, she received her undergraduate degree in chemistry from Texas A&M University and her doctorate degree in biochemistry from The University of Texas Southwestern Medical Center at Dallas. She completed postdoctoral fellowships in human molecular genetics with James Lupski at Baylor College of Medicine in Houston and with Michael Lovett at The University of Texas Southwestern Medical Center at Dallas. Dr. Wise is a founding member and chair of the International Consortium for Spinal Genetics, Development, and Disease. She also co-directs the TSRHC GOOD for KIDs program aimed at solving rare debilitating musculoskeletal diseases in children using next-generation genomic methods. Dr. Wise’s laboratory hosts the TSRHC Scoliosis Biobank and the U.S. DNA and Cell repository for the Primordial Registry, a joint effort with Dr. Michael Bober at A. I. duPont Hospital for Children. Dr. Wise leads NIH-funded projects focused on mechanistic understanding of adolescent idiopathic scoliosis, the most common musculoskeletal disorder in children, and on earlier onset forms. Education Undergraduate Texas A & M University (1985), Chemistry Graduate School UT Southwestern Medical Center (1991), Biochemistry Research Interest Genetic and Biochemical Causes of Pediatric Musculoskeletal Disorders Genetics Risk Factors for Idiopathic Scoliosis Publications The importance of imperfect pre-clinical models in adolescent idiopathic scoliosis Sepich DS, Gray RS, Ahituv N, Gurnett CA, Rios JJ, Solnica-Krezel L, Wise CA DMM Disease Models and Mechanisms 2025 Aug 18 Rare missense variants in FNDC1 are associated with severe adolescent idiopathic scoliosis Charng WL, Haller G, Whittle J, Nikolov M, Avery A, Morcuende J, Giampietro P, Raggio C, Miller N, Justice AE, Strande NT, Seeley M, Bodian DL, Wise CA, Sepich DS, Dobbs MB, Gurnett CA Journal of medical genetics 2025 Jul 62 427-435 Molecular Evidence Supporting MEK Inhibitor Therapy in NF1 Pseudarthrosis Paria N, Oxendine I, Podeszwa D, Wassell M, Cornelia R, Wise CA, Rios JJ Journal of Bone and Joint Surgery 2025 May 107 1098-1106 Biallelic SLC13A1 loss-of-function variants result in impaired sulfate transport and skeletal phenotypes, including short stature, scoliosis, and skeletal dysplasia Tise CG, Ashton K, de Hayr L, Lee KD, Patkar OL, Krzesinski E, Bassetti JA, Carter EM, Raggio C, Zankl A, Khanshour AM, Atala KN, Rios JJ, Wise CA, Zhu Y, Zhang F, Roscioli T, Buckley M, Harvey RJ, Dawson PA Genetics in Medicine Open 2025 Jan 3 Perspectives from the 2024 International Consortium for Spinal Genetics, Development and Disease (ICSGDD) Wu N, Hadley-Miller N, Gray R, Schauer S, Redding G, Cheng T, Chen Z, Yang J, Blecher R, Gerdhem P, Wise CA Genetics in Medicine Open 2025 Jan 3 Dominant missense variants in SREBF2 are associated with complex dermatological, neurological, and skeletal abnormalities Author Collaboration UD, Moulton MJ, Atala K, Zheng Y, Dutta D, Grange DK, Lin WW, Wegner DJ, Wambach JA, Duker AL, Bober MB, Kratz L, Wise CA, Oxendine I, Khanshour A, Bacino CA, Balasubramanyam A, Burrage LC, Chao HT, Chinn I, Clark GD, Craigen WJ, Dai H, Emrick LT, Ketkar S, Lalani SR, Lee BH, Lewis RA, Marom R, Orengo JP, Posey JE, Potocki L, Rosenfeld JA, Seto E, Scott DA, Tarakad A, Tran AA, Vogel TP, Hubshman MW, Worley K, Bellen HJ, Wangler MF, Yamamoto S, Kanca O, Eng CM, Liu P, Ward PA, Behrens E, Falk M, Izumi K, Rios J Genetics in Medicine 2024 Sep 26 Spatial transcriptomics implicates impaired BMP signaling in NF1 fracture pseudarthrosis in murine and patient tissues Rios JJ, Juan C, Shelton JM, Paria N, Oxendine I, Wassell M, Kidane YH, Cornelia R, Jeffery EC, Podeszwa DA, Conway SJ, Wise CA, Tower RJ JCI Insight 2024 Aug 9 Deep Learning-Based Automated Measurement of Murine Bone Length in Radiographs Rong R, Denton K, Jin KW, Quan P, Wen Z, Kozlitina J, Lyon S, Wang A, Wise CA, Beutler B, Yang DM, Li Q, Rios JJ, Xiao G Bioengineering 2024 Jul 11 Deletion of Pax1 scoliosis-associated regulatory elements leads to a female-biased tail abnormality Ushiki A, Sheng RR, Zhang Y, Zhao J, Nobuhara M, Murray E, Ruan X, Rios JJ, Wise CA, Ahituv N Cell Reports 2024 Mar 43 Impaired glycine neurotransmission causes adolescent idiopathic scoliosis Wang X, Yue M, Cheung JP, Cheung PW, Fan Y, Wu M, Wang X, Zhao S, Khanshour AM, Rios JJ, Chen Z, Wang X, Tu W, Chan D, Yuan Q, Qin D, Qiu G, Wu Z, Zhang TJ, Ikegawa S, Wu N, Wise CA, Hu Y, Luk KD, Song YQ, Gao B Journal of Clinical Investigation 2024 Jan 134 Results 1-10 of 135 1 2 3 4 5 Next Last Books Featured Books Molecular Genetics of Pediatric Orthopaedic Disorders (Ed.) (2014). New York, New York, Springer Honors & Awards Russell A. Hibbs Basic Science Award, Scoliosis Research Society (2014) Russell A. Hibbs Basic Science Award, Scoliosis Research Society (2012) Distinguished Service Award, Texas Genetics Society (2011) Community Builder Award, Brooklyn Lodge (2010) Anson Jones Award, Ft. Worth Scottish Rite Foundation (2009) Community Builder Award, John L. DeGrozier Lodge (2009) Forney High School Hall of Honor (2009) Texas Trailblazer, The Family Place (2008) YWCA Centennial Award (2007) Professional Associations/Affiliations Scottish Rite Hospital Children (1996) University of Texas Southwestern Medical Center (1997)
