1980 BA, Biochemistry Department, University of California, Berkeley

1987 PhD, Biochemistry Department, University of Washington, with Dr. Richard D. Palmiter Thesis: Transmission Ratio Distortion and Mosaicism in Transgenic Mice

1986-1992 NIH Postdoctoral Fellow with Dr. Melvin I. Simon, California Institute of Technology, Pasadena CA

Academic Appointments

1993 Assistant Professor, Department of Pharmacology

2000 Associate Professor, Department of Pharmacology

2011 Member, UTSW Simmons Comprehensive Cancer Center

2012 Adjunct Faculty, UT Dallas, Biological Sciences

2013 Director, UTSW First Year Graduate School Core Course

2014 co-Director, Mechanisms of Disease & Translational Science Graduate Track


Uni of California, Berkeley (1980), Biochemistry
Graduate School
University of Washington (1986), Biochemistry

Research Interest

  • G Protein Signaling in Pancreas Development, Adult Physiology and Behavior
  • Pancreatic cancer
  • Pancreatic islet and beta cell expansion in diabetes


Featured Publications LegendFeatured Publications

New roles for G alpha and RGS proteins: Communication continues despite driving sisters apart.
Wilkie TM & Kinch L. Current Biology November 2005 15 R843-R854
G alpha-q and G alpha-11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme.
Ivey K, Tyson B, Ukidwe P, McFadden D, Levi G, Olson E, Srivastava D & Wilkie TM Developmental Biology 2003 255 230-237
Regulators of G protein signaling provide biochemical control of agonist-evoked [Ca2+]i oscillations.
Luo X, Popov S, Bera AK, Wilkie TM & Muallem S Molecular Cell 2001 7 651-660
The N-terminal domain of RGS4 confers receptor selective inhibition of G protein signaling
Zeng W, Xu X, Popov S, Mukhopadhyay S, Chidiac P, Swistok J, Danho W, Yagaloff K, Fisher S, Ross EM, Muallem S & Wilkie TM J. Biol. Chem. 1998 273 34687-34690


Featured Books Legend Featured Books

Honors & Awards

  • Haberecht Wildhare-Idea Research Grant Award
    UT Southwestern (2016)
  • Outstanding Teacher Award
    UTSW Graduate School of Biomedical Sciences (2015)
  • Established Investigator Award
    American Heart Association (1996)
  • Starter Scholar Research Award
    Basil OConner MOD (1995)

Professional Associations/Affiliations

  • AACR (2010)
  • ASBMB (1988)
  • ASPET (1996)