Thomas Wilkie, Ph.D.

Education

1980 BA, Biochemistry Department, University of California, Berkeley

1987 PhD, Biochemistry Department, University of Washington, with Dr. Richard D. Palmiter Thesis: Transmission Ratio Distortion and Mosaicism in Transgenic Mice

1986-1992 NIH Postdoctoral Fellow with Dr. Melvin I. Simon, California Institute of Technology, Pasadena CA

Academic Appointments

1993 Assistant Professor, Department of Pharmacology

2000 Associate Professor, Department of Pharmacology

2011 Member, UTSW Simmons Comprehensive Cancer Center

2012 Adjunct Faculty, UT Dallas, Biological Sciences

2013 Director, UTSW First Year Graduate School Core Course

2014 co-Director, Mechanisms of Disease & Translational Science Graduate Track

Undergraduate

Uni of California, Berkeley (1980), Biochemistry

Graduate School

University of Washington (1986), Biochemistry

• G Protein Signaling in Pancreas Development, Adult Physiology and Behavior
• Pancreatic cancer
• Pancreatic islet and beta cell expansion in diabetes

Featured Publications

A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics.

Ocal O, Pashkov V, Kollipara RK, Heath BR, Zolghadri Y, Cruz VH, Hale M, Artyukhin AB, Christie AL, Tsoulfas P, Lorens JB, Swift GH, Brekken RA & Wilkie TM Disease Models & Mechanisms 2015 8 1201-1211

Regulator of G protein Signaling (Rgs16) inhibits hepatic fatty acid oxidation in a ChREBP-dependent manner

Pashkov V*, Huang J*, Parameswara VK, Kedzierski W, Kurrasch DM, Tall GG, Gerard RD, Esser V, Uyeda K, Towle H & Wilkie TM J Biol Chem April 2011 286 [Cover] 15116-15127

Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes

Villasenor A, Wang ZV, Rivera LB, Ocal O, Wernstedt Asterholm I, Scherer PE, Brekken RA, Cleaver O*, & Wilkie TM* Disease Models & Mechanisms September 2010 3 567-580

GTPase-activating proteins (GAPs) for heterotrimeric G proteins: Regulators of G protein signaling (RGS proteins) and their relatives.

Ross EM & Wilkie TM Annual Review of Biochemistry 2000 69 795-827

Ca2+/calmodulin reverses 3,4,5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity.

Popov S, Krishna UM, Falck JR & Wilkie TM J. Biol. Chem. 2000 275 18962-18968

GAIP and RGS4 are GTPase accelerating proteins (GAPs) for the Gi family of heterotrimeric guanine nucleotide binding proteins.

Berman DM, Wilkie TM & Gilman AG Cell 1996 86 445-452

New roles for G alpha and RGS proteins: Communication continues despite driving sisters apart.

Wilkie TM & Kinch L. Current Biology November 2005 15 R843-R854

G alpha-q and G alpha-11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme.

Ivey K, Tyson B, Ukidwe P, McFadden D, Levi G, Olson E, Srivastava D & Wilkie TM Developmental Biology 2003 255 230-237

Regulators of G protein signaling provide biochemical control of agonist-evoked [Ca2+]i oscillations.

Luo X, Popov S, Bera AK, Wilkie TM & Muallem S Molecular Cell 2001 7 651-660

The N-terminal domain of RGS4 confers receptor selective inhibition of G protein signaling

Zeng W, Xu X, Popov S, Mukhopadhyay S, Chidiac P, Swistok J, Danho W, Yagaloff K, Fisher S, Ross EM, Muallem S & Wilkie TM J. Biol. Chem. 1998 273 34687-34690

 Featured Books

RGS Protein Superfamily. In Encyclopedia of Hormones

Sierra DA & Wilkie TM (2003). San Diego CA, Academic Press

G proteins: Large and small guanine nucleotide binding proteins. In Principles of Molecular Regulation

Wilkie TM & White MA (2000). Totowa NJ, The Humana Press

Mammalian spermiogenesis: Assembly and fate of perinuclear theca constituents. In Cellular and Molecular Events in Spermatogenesis

Bellve AR, Thomas KH Chandrika R, Wilkie TM & Simon MI (1990). Cambridge, United Kingdom, Cambridge University Press

• Haberecht Wildhare-Idea Research Grant Award
  UT Southwestern (2016)
• Outstanding Teacher Award
  UTSW Graduate School of Biomedical Sciences (2015)
• Established Investigator Award
  American Heart Association (1996)
• Starter Scholar Research Award
  Basil OConner MOD (1995)

• AACR (2010)
• ASBMB (1988)
• ASPET (1996)