Thomas Wilkie, Ph.D. Associate Professor School Medical School Department Pharmacology Graduate Programs Cancer Biology, Genetics, Development and Disease Biography Education 1980 BA, Biochemistry Department, University of California, Berkeley 1987 PhD, Biochemistry Department, University of Washington, with Dr. Richard D. Palmiter Thesis: Transmission Ratio Distortion and Mosaicism in Transgenic Mice 1986-1992 NIH Postdoctoral Fellow with Dr. Melvin I. Simon, California Institute of Technology, Pasadena CA Academic Appointments 1993 Assistant Professor, Department of Pharmacology 2000 Associate Professor, Department of Pharmacology 2011 Member, UTSW Simmons Comprehensive Cancer Center 2012 Adjunct Faculty, UT Dallas, Biological Sciences 2013 Director, UTSW First Year Graduate School Core Course 2014 co-Director, Mechanisms of Disease & Translational Science Graduate Track Education Undergraduate Uni of California, Berkeley (1980), Biochemistry Graduate School University of Washington (1986), Biochemistry Research Interest G Protein Signaling in Pancreas Development, Adult Physiology and Behavior Pancreatic cancer Pancreatic islet and beta cell expansion in diabetes Publications Featured Publications A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics. Ocal O, Pashkov V, Kollipara RK, Heath BR, Zolghadri Y, Cruz VH, Hale M, Artyukhin AB, Christie AL, Tsoulfas P, Lorens JB, Swift GH, Brekken RA & Wilkie TM Disease Models & Mechanisms 2015 8 1201-1211 Regulator of G protein Signaling (Rgs16) inhibits hepatic fatty acid oxidation in a ChREBP-dependent manner Pashkov V*, Huang J*, Parameswara VK, Kedzierski W, Kurrasch DM, Tall GG, Gerard RD, Esser V, Uyeda K, Towle H & Wilkie TM J Biol Chem April 2011 286 [Cover] 15116-15127 Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes Villasenor A, Wang ZV, Rivera LB, Ocal O, Wernstedt Asterholm I, Scherer PE, Brekken RA, Cleaver O*, & Wilkie TM* Disease Models & Mechanisms September 2010 3 567-580 GTPase-activating proteins (GAPs) for heterotrimeric G proteins: Regulators of G protein signaling (RGS proteins) and their relatives. Ross EM & Wilkie TM Annual Review of Biochemistry 2000 69 795-827 Ca2+/calmodulin reverses 3,4,5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity. Popov S, Krishna UM, Falck JR & Wilkie TM J. Biol. Chem. 2000 275 18962-18968 GAIP and RGS4 are GTPase accelerating proteins (GAPs) for the Gi family of heterotrimeric guanine nucleotide binding proteins. Berman DM, Wilkie TM & Gilman AG Cell 1996 86 445-452 New roles for G alpha and RGS proteins: Communication continues despite driving sisters apart. Wilkie TM & Kinch L. Current Biology November 2005 15 R843-R854 G alpha-q and G alpha-11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme. Ivey K, Tyson B, Ukidwe P, McFadden D, Levi G, Olson E, Srivastava D & Wilkie TM Developmental Biology 2003 255 230-237 Regulators of G protein signaling provide biochemical control of agonist-evoked [Ca2+]i oscillations. Luo X, Popov S, Bera AK, Wilkie TM & Muallem S Molecular Cell 2001 7 651-660 The N-terminal domain of RGS4 confers receptor selective inhibition of G protein signaling Zeng W, Xu X, Popov S, Mukhopadhyay S, Chidiac P, Swistok J, Danho W, Yagaloff K, Fisher S, Ross EM, Muallem S & Wilkie TM J. Biol. Chem. 1998 273 34687-34690 Results 1-10 of 11 1 2 Next Last Books Featured Books RGS Protein Superfamily. In Encyclopedia of Hormones Sierra DA & Wilkie TM (2003). San Diego CA, Academic Press G proteins: Large and small guanine nucleotide binding proteins. In Principles of Molecular Regulation Wilkie TM & White MA (2000). Totowa NJ, The Humana Press Mammalian spermiogenesis: Assembly and fate of perinuclear theca constituents. In Cellular and Molecular Events in Spermatogenesis Bellve AR, Thomas KH Chandrika R, Wilkie TM & Simon MI (1990). Cambridge, United Kingdom, Cambridge University Press Honors & Awards Haberecht Wildhare-Idea Research Grant AwardUT Southwestern (2016) Outstanding Teacher AwardUTSW Graduate School of Biomedical Sciences (2015) Established Investigator AwardAmerican Heart Association (1996) Starter Scholar Research AwardBasil OConner MOD (1995) Professional Associations/Affiliations AACR (2010) ASBMB (1988) ASPET (1996)
