Featured Publications LegendFeatured Publications

Protein kinase inhibitor ? reciprocally regulates osteoblast and adipocyte differentiation by downregulating leukemia inhibitory factor.
Chen X, Hausman BS, Luo G, Zhou G, Murakami S, Rubin J, Greenfield EM Stem Cells 2013 Dec 31 12 2789-99
Stimulation of macrophage TNFalpha production by orthopaedic wear particles requires activation of the ERK1/2/Egr-1 and NF-kappaB pathways but is independent of p38 and JNK.
Beidelschies MA, Huang H, McMullen MR, Smith MV, Islam AS, Goldberg VM, Chen X, Nagy LE, Greenfield EM J. Cell. Physiol. 2008 Dec 217 3 652-66
Endogenous PKI gamma limits the duration of the anti-apoptotic effects of PTH and beta-adrenergic agonists in osteoblasts.
Chen X, Song IH, Dennis JE, Greenfield EM J. Bone Miner. Res. 2007 May 22 5 656-64
Lipopolysaccharide found in aseptic loosening of patients with inflammatory arthritis.
Nalepka JL, Lee MJ, Kraay MJ, Marcus RE, Goldberg VM, Chen X, Greenfield EM Clin. Orthop. Relat. Res. 2006 Oct 451 229-35
TNFalpha and PTH utilize distinct mechanisms to induce IL-6 and RANKL expression with markedly different kinetics.
Dai JC, He P, Chen X, Greenfield EM Bone 2006 Apr 38 4 509-20
Endogenous protein kinase inhibitor gamma terminates immediate-early gene expression induced by cAMP-dependent protein kinase (PKA) signaling: termination depends on PKA inactivation rather than PKA export from the nucleus.
Chen X, Dai JC, Orellana SA, Greenfield EM J. Biol. Chem. 2005 Jan 280 4 2700-7
Protein kinase inhibitor and the anabolic effects of PTH.
Chen X, Greenfield EM Ortho J CWRU 2005 2 279-94
Review: Regulation of PKA signaling by PKI in osteoblast.
Keenan E, Chen X, Greenfield EM Ortho J CWRU 2004 1 61-4
Termination of immediate-early gene expression after stimulation by parathyroid hormone or isoproterenol.
Chen X, Dai JC, Greenfield EM Am. J. Physiol., Cell Physiol. 2002 Nov 283 5 C1432-40
Effect of ?-adrenergic receptor kinase 1 (?ARK1) on the very rapid phase homologous desensitization of PTH/PTHrP receptor in rat osteoblastic osteosarcoma cell, ROS17/2.8.
Chen X, Nakata H, Baba H J Kobe Univ Sch Med 2001 62 1-10


Featured Books Legend Featured Books

Use of siRNA and antisense knockdown to study regulation of PKA by PKI.. In Handbook of Cell Signaling (Second Edition)

Greenfield EM & Chen X (2010). New York, NY, El Sevier