2018-Present: Assistant Professor, Department of Immunology, UT Southwestern Medical Center

2013-2018: Postdoctoral Fellow, Department of Pharmacology, University of California, San Diego

2006-2013: Ph.D Student, Department of Microbiology and Immunology, Loyola University Chicago

Research Interest

  • Chronic Liver Diseases
  • Innate Immunity
  • Mitochondrial Stress Reponse
  • Tumor Immunology


Featured Publications LegendFeatured Publications

Soluble a-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia.
Trudler D, Nazor KL, Eisele YS, Grabauskas T, Dolatabadi N, Parker J, Sultan A, Zhong Z, Goodwin MS, Levites Y, Golde TE, Kelly JW, Sierks MR, Schork NJ, Karin M, Ambasudhan R, Lipton SA, Proc Natl Acad Sci U S A 2021 Apr 118 15
Murine macrophage autophagy protects against alcohol-induced liver injury by degrading interferon regulatory factor 1 (IRF1) and removing damaged mitochondria.
Liang S, Zhong Z, Kim SY, Uchiyama R, Roh YS, Matsushita H, Gottlieb RA, Seki E, J. Biol. Chem. 2019 Jun
Choline Uptake and Metabolism Modulate Macrophage IL-1ß and IL-18 Production.
Sanchez-Lopez E, Zhong Z, Stubelius A, Sweeney SR, Booshehri LM, Antonucci L, Liu-Bryan R, Lodi A, Terkeltaub R, Lacal JC, Murphy AN, Hoffman HM, Tiziani S, Guma M, Karin M, Cell Metab. 2019 Apr

Honors & Awards

  • NIH/NIGMS MIRA R35 Award
  • American Cancer Society IRG Award
  • Milstein Young Investigator Award, International Cytokine and Interferon Society
  • NIH/NIAID K22 Career Transition Award
  • UT Southwestern Circle of Friends Award in Cancer Research
  • Cancer Prevention Research Institute of Texas (CPRIT) Scholar Recruitment of First-Time, Tenure-Track Faculty Members
  • University of Texas System Rising STARs Award
  • American Association for the Study of Liver Diseases (AASLD) Pinnacle Research Award
  • Prevent Cancer Foundation Board of Directors Award
  • American Association of Immunologists (AAI) Trainee Achievement Award
  • Cancer Research Institute Irvington Postdoctoral Fellowship Award

Professional Associations/Affiliations

  • International Cytokine and Interferon Society (2020)
  • American Association for the Study of Liver Diseases (2017)
  • American Association for Cancer Research (2012)
  • American Association of Immunologists (2010)