2018-Present: Assistant Professor, Department of Immunology, UT Southwestern Medical Center

2013-2018: Postdoctoral Fellow, Department of Pharmacology, University of California, San Diego

2006-2013: Graduate Student, Department of Microbiology and Immunology, Loyola University Chicago

Research Interest

  • Cancer Vaccine
  • Chronic Liver Diseases
  • Hepatocellular Carcinoma
  • Innate Immunity
  • Mitochondrial Stress Reponses
  • Neuroinflammation
  • Tumor Immunology


Featured Publications LegendFeatured Publications

NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice.
Liang S, Ma HY, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, Ganguly S, Lan T, Karin M, Kisseleva T, Brenner DA Gastroenterology 2018 Nov
Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity.
Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M Nature 2017 Nov 551 7680 340-345
p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells.
Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M Cancer Cell 2016 06 29 6 935-948
Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy.
Shalapour S, Font-Burgada J, Di Caro G, Zhong Z, Sanchez-Lopez E, Dhar D, Willimsky G, Ammirante M, Strasner A, Hansel DE, Jamieson C, Kane CJ, Klatte T, Birner P, Kenner L, Karin M Nature 2015 May 521 7550 94-8

Honors & Awards

  • Cancer Prevention Research Institute of Texas (CPRIT) Scholar Recruitment of First-Time, Tenure-Track Faculty Members
  • University of Texas System Rising STARs Award
  • American Association for the Study of Liver Diseases (AASLD) Pinnacle Research Award
  • Prevent Cancer Foundation Board of Directors Award
  • American Association of Immunologists (AAI) Trainee Achievement Award
  • Cancer Research Institute Irvington Postdoctoral Fellowship Award

Professional Associations/Affiliations

  • American Association for the Study of Liver Diseases (2017)
  • American Association for Cancer Research (2012)
  • American Association of Immunologists (2010)