Jonathan Weissler, M.D., is a Professor in the Department of Internal Medicine at UT Southwestern Medical Center and holds the James M. Collins Professorship in Biomedical Research. He is the Chief of Medicine for UT Southwestern University Hospitals.

Dr. Weissler earned his medical degree from the New York University School of Medicine and completed his residency and fellowship in pulmonary diseases at UT Southwestern Medical Center.

Certified by the American Board of Internal Medicine, he joined the UT Southwestern faculty in 1985.

His areas of clinical expertise include pulmonology and critical care medicine. In his role as Chief of Medicine, Dr. Weissler supervises the housestaff, residents, and medical students at UT Southwestern University Hospitals. In his career, he has served as Chief of Pulmonary and Critical Care Medicine and Director of Respiratory Therapy at Parkland Memorial Hospital. Dr. Weissler is active in training the next generation of pulmonary and critical care doctors through UT Southwestern's academic programs.

Among many honors and awards, Dr. Weissler has been recognized as a Best Doctor by D Magazine and a Super Doctor by Texas Monthly.


Medical School
New York University School of Medicine (1979)
UT Southwestern Medical Center (1982), Internal Medicine
UT Southwestern Medical Center (1985), Pulmonary Diseases

Research Interest

  • Idiopathic Pulmonary Fibrosis
  • Severe Asthma
  • Transcriptional Regulation of Surfactant proteins


Featured Publications LegendFeatured Publications

PLAGL-2 expression induced epithelium damages in emphysema
Yang, Y.S., Yang M.C.,Guo M, and J.C. Weissler Am J Phys (Lung) September 2009 297 455-466
Nuclear relocation of PLAGL2 modulates gene activity in hypoxic lung cells: a mechanism in maintaining SP-C expression
Guo,Y., Yang,M.C., Weissler, J.C., and Y.S. Yang Biochem and Biophys Res Communications August 2007 360 (3) 659-665
Adult-onset pulmonary fibrosis caused by mutations in telomerase
Tsakiri,K.,Cronkhite,J.,Kuan,P.,Xing,C.,Raghu,G.,Weissler J.C., Rosenblatt R.,Shay,J.,Garcia, C.K. PNAS May 2007 Vol 104, No. 18 7552-7557
TTF-1/TAP26 Complex Differentially Modulates Surfactant Protein-B (SP-B) and -C (SP-C) Promoters in Lung Cells
Yang, M.C., Guo,Y, Liu, C, Deng, F, Weissler J.C., and Y.S. Yang Biochem and Biophys Res Communications June 2006 344 (2) 484-490
Pleiomorphic Adenoma Gene-like 2 Expression Is Associated with the Development of Lung Adenocarcinoma and Emphysema
Yih-Sheng Yang, Meng-Chun W. Yang, and J.C. Weissler Lung Cancer Oct 2011 72(2) in press

Honors & Awards

  • President, Association of Subspecialty Professors
  • Best Doctors in America
  • America's Top Doctors
  • President, Association of Pulmonary and Critical Care Medicine Program Directors
  • President, American Federation for Clinical Research

Professional Associations/Affiliations

  • American College of Physicians
  • American Thoracic Society
  • Dallas County Medical Society
  • Texas Medical Association