Dagan Segal, Ph.D.

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Since October 2021, Dagan Segal has been appointed as Instructor in the Lyda Hill Department of Bioinformatics. Since March 2021, she is also a member of the Cecil H. and Ida Green Center for Systems Biology. Prior to joining UT Southwestern, Dr. Segal received her PhD degree from Weizmann University in Rehovot, Israel.

 

Dr. Segal currently performs research in Dr. Gaudenz Danuser’s lab in the Lyda Hill Department of Bioninformatics, where she combines in vitro and zebrafish models to study mechanisms of cancer cell plasticity in Ewing Sarcoma. Specific areas of interest include cellular response to microenvironmental cues and the role of Caveolin-1 in cancer cell adaptation. Her work is supported by an EMBO long-term research fellowship.

Featured Publications

In vivo 3D profiling of site-specific human cancer cell morphotypes in zebrafish.

Segal D, Mazloom-Farsibaf H, Chang BJ, Roudot P, Rajendran D, Daetwyler S, Fiolka R, Warren M, Amatruda JF, Danuser G, J Cell Biol 2022 Nov 221 11

Feedback inhibition of actin on Rho mediates content release from large secretory vesicles.

Segal D, Zaritsky A, Schejter ED, Shilo BZ, J Cell Biol 2018 05 217 5 1815-1826

Adhesion and Fusion of Muscle Cells Are Promoted by Filopodia.

Segal D, Dhanyasi N, Schejter ED, Shilo BZ, Dev Cell 2016 08 38 3 291-304

The AHR target gene Scinderin activates the WNT pathway by facilitating the nuclear translocation of ?-catenin.

Perez-Castro L, Venkateswaran N, Garcia R, Hao YH, Lafita-Navarro MC, Kim J, Segal D, Saponzik E, Chang BJ, Fiolka R, Danuser G, Xu L, Brabletz T, Conacci-Sorrell M, J Cell Sci 2022 Sep