Syed Kazmi, M.D. Titles and Appointments Associate Professor Endowed Title Eugene P. Frenkel, M.D. Scholar in Clinical Medicine School Medical School Department Internal Medicine You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Syed Kazmi, M.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center, and a member of the Division of Hematology and Oncology. A Eugene P. Frenkel, M.D. Scholar in Clinical Medicine, his clinical focus is gastrointestinal malignancies. A native of Pakistan, Dr. Kazmi received his medical degree from Aga Khan University and his master’s degree in biological and biomedical sciences from the University of Glasgow. He completed internal medicine residency training at UT Health Science Center in Houston, then completed advanced training through a fellowship in hematology and oncology at MD Anderson Cancer Center, where he was Chief Fellow for hematology and received the Young Investigator Award from the ASCO Conquer Cancer Foundation. Certified by the American Board of Internal Medicine in hematology and oncology, Dr. Kazmi joined the UT Southwestern faculty in 2017. Dr. Kazmi’s research interests include clinical and translational research in colorectal cancer and quality improvement in clinical oncology. His investigations have resulted in several publications in peer-reviewed journals. At UT Southwestern, Dr. Kazmi teaches medical and graduate students in classroom settings, lectures, and clinical experience. He has been part of several quality-improvement projects, including better documentation of nutrition in GI cancer patients, and introduction to chemotherapy for patients at UT Southwestern and Parkland Memorial Hospital. Dr. Kazmi is a member of the American Society of Clinical Oncology and section editor for Systemic Therapies in Colorectal Cancer for Current Colorectal Cancer Reports. Personal Note Outside of medicine, Dr. Kazmi likes to spend time with family, cook, and enjoy outdoor activities. Education Medical School Aga Khan University, Pakistan (2004) Medical School University of Glasgow, UK (2006) Residency UT Medical Branch at Houston (2010), Internal Medicine Fellowship UT MD Anderson Cancer Center (2013), Hematology Oncology Research Interest Clinical and Translational Research in Colorectal Cancer Quality Assessment and Improvement in Clinical Oncology Publications Featured Publications Gastric adenocarcinoma with recurrence as cutaneous metastatic disease. Sawyer M, Brown T, Kazmi S, Verma N, BMJ Case Rep 2025 Aug 18 8 Comprehensive analysis of PIK3CA mutations in advanced colorectal cancer using circulating tumor DNA profiling. Milsap A, Tsai J, Jafry B, Kim A, Ali Kazmi SM, Verma N, NPJ Precis Oncol 2025 Jul 9 1 220 Phase 1 first-in-human dose-escalation study of IMSA101, a novel cyclic di-nucleotide STING agonist, for patients with advanced solid tumor malignancies. Jacoby J, Mahalingam D, Alistar A, Garmey E, Kazmi S, Mooneyham T, Sun L, Yap TA, Vu P, Moser J, J Immunother Cancer 2025 Jun 13 6 Presurgical ablative radiation is associated with local control and immune response in pancreatic cancer. Leung PQ, Elghonaimy EA, Elamir AM, Wachsmann M, Zhang S, Barrows N, Notgrass H, Johnson E, Lewis CM, von Ebers R, Hamilton C, Castillo-Flores S, Nunez-Rocha RE, Josephson G, Chi Z, Al Mutar S, Polanco PM, Sanford NN, Ali Kazmi SM, Porembka MR, Hsiehchen D, Yopp AC, Mansour JC, Beg MS, Zeh HJ, Aguilera TA, Clin Cancer Res 2025 May Trastuzumab Plus Pertuzumab Versus Cetuximab Plus Irinotecan in Patients With RAS/BRAF Wild-Type, HER2-Positive, Metastatic Colorectal Cancer (S1613): A Randomized Phase II Trial. Raghav KPS, Guthrie KA, Tan B, Denlinger CS, Fakih M, Overman MJ, Dasari NA, Corum LR, Hicks LG, Patel MS, Esparaz BT, Kazmi SM, Alluri N, Colby S, Gholami S, Gold PJ, Chiorean EG, Kopetz S, Hochster HS, Philip PA, J Clin Oncol 2025 Jan JCO2401710 Clinical, pathological, and adjuvant chemotherapy use differences among microsatellite unstable and microsatellite stable colon cancers. Jafry BH, Buhaya MH, Milsap A, Jones AL, Goksu SY, Verma N, Brown TJ, Hughes A, Nair R, Sanford N, Su J, Huang E, Kazmi SMA, J Natl Cancer Cent 2024 Jun 4 2 169-175 Transferring care to enhance access to early-phase cancer clinical trials: Protocol to evaluate a novel program. Nwachukwu C, Makhnoon S, Person M, Muthukrishnan M, Kazmi S, Anderson LD, Kaur G, Kapinos KA, Williams EL, Fatunde O, Sadeghi N, Robles F, Basey A, Hulsey T, Pruitt SL, Gerber DE, Contemp Clin Trials Commun 2024 Jun 39 101292 Making progress against rare cancers: A case study on neuroendocrine tumors. O'Rorke M, Chrischilles E, Cancer 2024 May 130 9 1568-1574 The phosphatidylserine targeting antibody bavituximab plus pembrolizumab in unresectable hepatocellular carcinoma: a phase 2 trial. Hsiehchen D, Beg MS, Kainthla R, Lohrey J, Kazmi SM, Khosama L, Maxwell MC, Kline H, Katz C, Hassan A, Kubota N, Siglinsky E, Pillai AK, Youssoufian H, Mockbee C, Culm K, Uhlik M, Benjamin L, Brekken RA, Ahn C, Singal AG, Zhu H, Hoshida Y, Yopp AC, Nat Commun 2024 Mar 15 1 2178 Characteristics and clinical outcomes in young-onset cholangiocarcinoma. Reddy S, Goksu SY, Sanford NN, Kainthla R, Hsiehchen D, Sanjeevaiah A, Jones AL, Karagkounis G, Al Mutar S, Ahn C, Beg MS, Kazmi SM, Cancer Med 2023 Jul 12 13 14094-14103 Results 1-10 of 32 1 2 3 4 Next Last Honors & Awards Young Investigator AwardAmerican Society of Clinical Oncology (2012-2013) Best Teacher AwardAga Khan University (2005) Commonwealth Shared Scholarship Program Recipient AwardUniversity of Glasgow/Department of International Development, UK (2005-2006) Best Graduate of Medical ClassAga Khan University (2004) Professional Associations/Affiliations American Society of Clinical Oncology (2010)
