Huiming Lu, Ph.D. Titles and Appointments Assistant Professor School Medical School Department Radiation Oncology Education Undergraduate Zhejiang University (2004), Agriculture Graduate School Zhejiang University (2009), Biophysics Research Interest DNA double-strand breaks (DSBs) induce genome instability, trigger cellular senescence and cell death, resulting in diseases. I am pursuing the molecular mechanisms of DSB repair and their relevance to unhealthy aging and tumorigenesis. I am also seeking potential clinical applications by targeting DSB repair pathways. Publications Defective homologous recombination and genomic instability predict increased responsiveness to carbon ion radiotherapy in pancreatic cancer Sishc BJ, Saha J, Alves EM, Ding L, Lu H, Wang SY, Swancutt KL, Nicholson JH, Facoetti A, Pompos A, Ciocca M, Aguilera TA, Story MD, Davis AJ npj Precision Oncology 2025 Dec 9 Non-homologous end joining shapes the genomic rearrangement landscape of chromothripsis from mitotic errors Hu Q, Espejo Valle-Inclán J, Dahiya R, Guyer A, Mazzagatti A, Maurais EG, Engel JL, Lu H, Davis AJ, Cortés-Ciriano I, Ly P Nature communications 2024 Dec 15 ATM phosphorylates the FATC domain of DNA-PKcsat threonine 4102 to promote non-homologous end joining Lu H, Zhang Q, Laverty DJ, Puncheon AC, Augustine MM, Williams GJ, Nagel ZD, Chen PB, Davis AJ Nucleic acids research 2023 Jul 51 6770-6783 DNA-PKcs-dependent phosphorylation of RECQL4 promotes NHEJ by stabilizing the NHEJ machinery at DNA double-strand breaks Lu H, Guan J, Wang SY, Li G, Bohr VA, Davis AJ Nucleic acids research 2022 Jun 50 5635-5651 Restoration of DNA repair mitigates genome instability and increases productivity of Chinese hamster ovary cells Spahn PN, Zhang X, Hu Q, Lu H, Hamaker NK, Hefzi H, Li S, Kuo CC, Huang Y, Lee JC, Davis AJ, Ly P, Lee KH, Lewis NE Biotechnology and Bioengineering 2022 Mar 119 963-982 Ablating putative Ku70 phosphorylation sites results in defective DNA damage repair and spontaneous induction of hepatocellular carcinoma Saha J, Bae J, Wang SY, Lu H, Chappell LJ, Gopal P, Davis AJ Nucleic acids research 2021 Sep 49 9836-9850 Human RecQ Helicases in DNA Double-Strand Break Repair Lu H, Davis AJ Frontiers in Cell and Developmental Biology 2021 Feb 9 MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway Guan J, Lu C, Jin Q, Lu H, Chen X, Tian L, Zhang Y, Ortega J, Zhang J, Siteni S, Chen M, Gu L, Shay JW, Davis AJ, Chen ZJ, Fu YX, Li GM Cancer Cell 2021 Jan 39 109-121.e5 DNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage response Lu H, Saha J, Beckmann PJ, Hendrickson EA, Davis AJ Nucleic acids research 2019 Oct 47 9467-9479 Regulation of the Intranuclear Distribution of the Cockayne Syndrome Proteins Iyama T, Okur MN, Golato T, McNeill DR, Lu H, Hamilton R, Raja A, Bohr VA, Wilson DM Scientific reports 2018 Dec 8 Results 1-10 of 39 1 2 3 4 Next Last Professional Associations/Affiliations American Association for Cancer Research (2021) American Society for Biochemistry and Molecular Biology (2021) Radiation Research Society (2018)
