Education
Undergraduate
Zhejiang University (2004), Agriculture
Graduate School
Zhejiang University (2009), Biophysics

Research Interest
  • DNA double-strand breaks (DSBs) induce genome instability, trigger cellular senescence and cell death, resulting in diseases. I am pursuing the molecular mechanisms of DSB repair and their relevance to unhealthy aging and tumorigenesis. I am also seeking potential clinical applications by targeting DSB repair pathways.

Publications
ATM phosphorylates the FATC domain of DNA-PKcsat threonine 4102 to promote non-homologous end joining
Lu H, Zhang Q, Laverty DJ, Puncheon AC, Augustine MM, Williams GJ, Nagel ZD, Chen BP, Davis AJ Nucleic acids research 2023 Jul 51 6770-6783
DNA-PKcs-dependent phosphorylation of RECQL4 promotes NHEJ by stabilizing the NHEJ machinery at DNA double-strand breaks
Lu H, Guan J, Wang SY, Li GM, Bohr VA, Davis AJ Nucleic acids research 2022 Jun 50 5635-5651
Restoration of DNA repair mitigates genome instability and increases productivity of Chinese hamster ovary cells
Spahn PN, Zhang X, Hu Q, Lu H, Hamaker NK, Hefzi H, Li S, Kuo CC, Huang Y, Lee JC, Davis AJ, Ly P, Lee KH, Lewis NE Biotechnology and Bioengineering 2022 Mar 119 963-982
Ablating putative Ku70 phosphorylation sites results in defective DNA damage repair and spontaneous induction of hepatocellular carcinoma
Saha J, Bae J, Wang SY, Lu H, Chappell LJ, Gopal P, Davis AJ Nucleic acids research 2021 Sep 49 9836-9850
Human RecQ Helicases in DNA Double-Strand Break Repair
Lu H, Davis AJ Frontiers in Cell and Developmental Biology 2021 Feb 9
MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway
Guan J, Lu C, Jin Q, Lu H, Chen X, Tian L, Zhang Y, Ortega J, Zhang J, Siteni S, Chen M, Gu L, Shay JW, Davis AJ, Chen ZJ, Fu YX, Li GM Cancer Cell 2021 Jan 39 109-121.e5
DNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage response
Lu H, Saha J, Beckmann PJ, Hendrickson EA, Davis AJ Nucleic acids research 2019 Oct 47 9467-9479
Regulation of the Intranuclear Distribution of the Cockayne Syndrome Proteins
Iyama T, Okur MN, Golato T, McNeill DR, Lu H, Hamilton R, Raja A, Bohr VA, Wilson DM Scientific reports 2018 Dec 8
DNA polymerase beta participates in mitochondrial DNA repair
Sykora P, Kanno S, Akbari M, Kulikowicz T, Baptiste BA, Leandro GS, Lu H, Tian J, May A, Becker KA, Croteau DL, Wilson DM, Sobol RW, Yasui A, Bohr VA Molecular and cellular biology 2017 Aug 37
WRN regulates pathway choice between classical and alternative non-homologous end joining
Shamanna RA, Lu H, De Freitas JK, Tian J, Croteau DL, Bohr VA Nature communications 2016 Dec 7

Professional Associations/Affiliations
  • American Association for Cancer Research (2021)
  • American Society for Biochemistry and Molecular Biology (2021)
  • Radiation Research Society (2018)