
Huiming Lu, Ph.D.
Assistant Professor
School Medical School
Department Radiation Oncology
Education
- Undergraduate
- Zhejiang University (2004), Agriculture
- Graduate School
- Zhejiang University (2009), Biophysics
Research Interest
- DNA double-strand breaks (DSBs) induce genome instability, trigger cellular senescence and cell death, resulting in diseases. I am pursuing the molecular mechanisms of DSB repair and their relevance to unhealthy aging and tumorigenesis. I am also seeking potential clinical applications by targeting DSB repair pathways.
Publications
- ATM phosphorylates the FATC domain of DNA-PKcsat threonine 4102 to promote non-homologous end joining
- Lu H, Zhang Q, Laverty DJ, Puncheon AC, Augustine MM, Williams GJ, Nagel ZD, Chen PB, Davis AJ Nucleic acids research 2023 Jul 51 6770-6783
- DNA-PKcs-dependent phosphorylation of RECQL4 promotes NHEJ by stabilizing the NHEJ machinery at DNA double-strand breaks
- Lu H, Guan J, Wang SY, Li GM, Bohr VA, Davis AJ Nucleic acids research 2022 Jun 50 5635-5651
- Restoration of DNA repair mitigates genome instability and increases productivity of Chinese hamster ovary cells
- Spahn PN, Zhang X, Hu Q, Lu H, Hamaker NK, Hefzi H, Li S, Kuo CC, Huang Y, Lee JC, Davis AJ, Ly P, Lee KH, Lewis NE Biotechnology and Bioengineering 2022 Mar 119 963-982
- Ablating putative Ku70 phosphorylation sites results in defective DNA damage repair and spontaneous induction of hepatocellular carcinoma
- Saha J, Bae J, Wang SY, Lu H, Chappell LJ, Gopal P, Davis AJ Nucleic acids research 2021 Sep 49 9836-9850
- Human RecQ Helicases in DNA Double-Strand Break Repair
- Lu H, Davis AJ Frontiers in Cell and Developmental Biology 2021 Feb 9
- MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway
- Guan J, Lu C, Jin Q, Lu H, Chen X, Tian L, Zhang Y, Ortega J, Zhang J, Siteni S, Chen M, Gu L, Shay JW, Davis AJ, Chen ZJ, Fu YX, Li GM Cancer Cell 2021 Jan 39 109-121.e5
- DNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage response
- Lu H, Saha J, Beckmann PJ, Hendrickson EA, Davis AJ Nucleic acids research 2019 Oct 47 9467-9479
- Regulation of the Intranuclear Distribution of the Cockayne Syndrome Proteins
- Iyama T, Okur MN, Golato T, McNeill DR, Lu H, Hamilton R, Raja A, Bohr VA, Wilson DM Scientific reports 2018 Dec 8
- DNA polymerase beta participates in mitochondrial DNA repair
- Sykora P, Kanno S, Akbari M, Kulikowicz T, Baptiste BA, Leandro GS, Lu H, Tian J, May A, Becker KA, Croteau DL, Wilson DM, Sobol RW, Yasui A, Bohr VA Molecular and cellular biology 2017 Aug 37
- WRN regulates pathway choice between classical and alternative non-homologous end joining
- Shamanna RA, Lu H, De Freitas JK, Tian J, Croteau DL, Bohr VA Nature communications 2016 Dec 7
Professional Associations/Affiliations
- American Association for Cancer Research (2021)
- American Society for Biochemistry and Molecular Biology (2021)
- Radiation Research Society (2018)