Zhejiang University (2004), Agriculture
Graduate School
Zhejiang University (2009), Biophysics

Research Interest

  • DNA double-strand breaks (DSBs) induce genome instability, trigger cellular senescence and cell death, resulting in diseases. I am pursuing the molecular mechanisms of DSB repair and their relevance to unhealthy aging and tumorigenesis. I am also seeking potential clinical applications by targeting DSB repair pathways.


Featured Publications LegendFeatured Publications

Ablating putative Ku70 phosphorylation sites results in defective DNA damage repair and spontaneous induction of hepatocellular carcinoma.
Saha J, Bae J, Wang SY, Lu H, Chappell LJ, Gopal P, Davis AJ, Nucleic Acids Res 2021 Aug
Human RecQ Helicases in DNA Double-Strand Break Repair.
Lu H, Davis AJ, Front Cell Dev Biol 2021 9 640755
MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway.
Guan J, Lu C, Jin Q, Lu H, Chen X, Tian L, Zhang Y, Ortega J, Zhang J, Siteni S, Chen M, Gu L, Shay JW, Davis AJ, Chen ZJ, Fu YX, Li GM, Cancer Cell 2020 Dec
WRN regulates pathway choice between classical and alternative non-homologous end joining.
Shamanna RA, Lu H, de Freitas JK, Tian J, Croteau DL, Bohr VA Nat Commun 2016 Dec 7 13785
NAD(+) Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair.
Fang EF, Kassahun H, Croteau DL, Scheibye-Knudsen M, Marosi K, Lu H, Shamanna RA, Kalyanasundaram S, Bollineni RC, Wilson MA, Iser WB, Wollman BN, Morevati M, Li J, Kerr JS, Lu Q, Waltz TB, Tian J, Sinclair DA, Mattson MP, Nilsen H, Bohr VA Cell Metab. 2016 Oct 24 4 566-581
RECQL4 helicase has oncogenic potential in sporadic breast cancers.
Arora A, Agarwal D, Abdel-Fatah TM, Lu H, Croteau DL, Moseley P, Aleskandarany MA, Green AR, Ball G, Rakha EA, Chan SY, Ellis IO, Wang LL, Zhao Y, Balajee AS, Bohr VA, Madhusudan S, J Pathol 2016 Mar 238 4 495-501

Professional Associations/Affiliations

  • American Association for Cancer Research (2021)
  • American Society for Biochemistry and Molecular Biology (2021)
  • Radiation Research Society (2018)