Biography

2011-2017 Post-doc, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

2005-2011 Ph.D., Molecular and Cell Biology, University of California, Berkeley

2001-2005 B.S., Biology, University of Texas at Austin

Research Overview: Eggs can survive in a dormant state for many years. They then dramatically reawaken upon fertilization and give rise to a complex organism. How does this happen?  The Woodruff lab combines live-cell imaging, nano-rheology, and in vitro reconstiution to address how organelles assemble and disassemble following fertilization.  The lab also focuses on protein quality control and stability in oocytes. With this knowledge, we can hopefully better understand how cell division errors arise during cellular ageing and contribute to cancer and fertility decline during advanced materal age.

 

Research Interest

  • Biochemistry, cell biology, and synthetic biology
  • CRISPR/Cas9 modification of embryos
  • Material properties of organelles
  • Oocyte quality and age-related fertility problems
  • Regulation of centrosome size and number

Publications

Featured Publications LegendFeatured Publications

FlexiBAC: a versatile, open-source baculovirus vector system for protein expression, secretion, and proteolytic processing.
Lemaitre RP, Bogdanova A, Borgonovo B, Woodruff JB, Drechsel DN, BMC Biotechnol. 2019 03 19 1 20
Assembly of Mitotic Structures through Phase Separation.
Woodruff JB J. Mol. Biol. 2018 May
Organization and Function of Non-dynamic Biomolecular Condensates.
Woodruff JB, Hyman AA, Boke E Trends Biochem. Sci. 2017 Dec
Phosphatase PP2A and microtubule-mediated pulling forces disassemble centrosomes during mitotic exit.
Enos SJ, Dressler M, Gomes BF, Hyman AA, Woodruff JB Biol Open 2017 Dec
Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation.
Wueseke O, Zwicker D, Schwager A, Wong YL, Oegema K, Jülicher F, Hyman AA, Woodruff JB Biol Open 2016 Oct 5 10 1431-1440
Method: In vitro analysis of pericentriolar material assembly.
Woodruff JB, Hyman AA Methods Cell Biol. 2015 129 369-82
The Caenorhabditis elegans pericentriolar material components SPD-2 and SPD-5 are monomeric in the cytoplasm before incorporation into the PCM matrix.
Wueseke O, Bunkenborg J, Hein MY, Zinke A, Viscardi V, Woodruff JB, Oegema K, Mann M, Andersen JS, Hyman AA Mol. Biol. Cell 2014 Oct 25 19 2984-92
Pericentriolar material structure and dynamics.
Woodruff JB, Wueseke O, Hyman AA Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2014 Sep 369 1650

Honors & Awards

  • CPRIT Recruitment Award
    (2018)
  • EMBO Long-Term Postdoctoral Fellow
    (2013-2015)
  • Alexander von Humboldt Postdoctoral Fellow
    (2012-2013)
  • Weintraub Graduate Student Award nominee
    (2011)
  • NSF Graduate Research Fellowship
    (2006-2009)
  • Dean's Honored Graduate, UT Austin
    (2005)