Chao Li, Ph.D.

Chao Li, Ph.D., is an Instructor in the Department of Internal Medicine at UT Southwestern Medical Center in the Touchstone Center for Diabetes Research.

Dr. Li earned his doctoral degree at Shanghai Institute of Nutrition and Health Chinese Academy of Sciences and completed metabolic and cardiovascular disease fellowship training at UT Southwester Medical Center.

Dr. Li joined the UT Southwestern faculty in 2023. 

Dr. Li's research focuses on the molecular mechanism of heart and metabolic diseases. He has published numerous academic articles on these topics.

 

• The molecular mechanism of cardiovascular and metabolic disease

Featured Publications

Nuclear receptor corepressor 1 represses cardiac hypertrophy.

Li C, Sun XN, Chen BY, Zeng MR, Du LJ, Liu T, Gu HH, Liu Y, Li YL, Zhou LJ, Zheng XJ, Zhang YY, Zhang WC, Liu Y, Shi C, Shao S, Shi XR, Yi Y, Liu X, Wang J, Auwerx J, Wang ZV, Jia F, Li RG, Duan SZ, EMBO Mol Med 2019 Sep e9127

Mineralocorticoid Receptor Deficiency in T Cells Attenuates Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction Through Modulating T-Cell Activation.

Li C, Sun XN, Zeng MR, Zheng XJ, Zhang YY, Wan Q, Zhang WC, Shi C, Du LJ, Ai TJ, Liu Y, Liu Y, Du LL, Yi Y, Yu Y, Duan SZ Hypertension 2017 07 70 1 137-147

T Cell Mineralocorticoid Receptor Controls Blood Pressure by Regulating Interferon Gamma.

Sun XN, Li C, Liu Y, Du LJ, Zeng MR, Zheng XJ, Zhang WC, Liu Y, Zhu M, Kong D, Zhou L, Lu L, Shen ZX, Yi Y, Du L, Qin M, Liu X, Hua Z, Sun S, Yin H, Zhou B, Yu Y, Zhang Z, Duan SZ Circ. Res. 2017 Mar

Protective roles of adiponectin and molecular signatures of HNF4α and PPARα as downstream targets of adiponectin in pancreatic β cells.

Onodera T, Kim DS, Ye R, Wang MY, Chen S, Field BC, Straub L, Sun XN, Li C, Lee C, Paredes M, Crewe C, Zhao S, Kusminski CM, Gordillo R, Scherer PE, Mol Metab 2023 Oct 78 101821

GPR84-mediated signal transduction effects metabolic function by promoting brown adipocyte activity.

Sun X, An YA, Paschoal VA, De Souza CO, Wang MY, Vishvanath L, Bueno LM, Cobb AS, Nieto Carrion JA, Ibe ME, Li C, Kidd HA, Chen S, Li W, Gupta RK, Oh DY, J Clin Invest 2023 Oct

Crosstalk Between Adipose Tissue and the Heart: An Update.

Li C, Sun XN, Zhao S, Scherer PE, J Transl Int Med 2022 Sep 10 3 219-226

ATF4 Protects the Heart From Failure by Antagonizing Oxidative Stress.

Wang X, Zhang G, Dasgupta S, Niewold EL, Li C, Li Q, Luo X, Tan L, Ferdous A, Lorenzi PL, Rothermel BA, Gillette TG, Adams CM, Scherer PE, Hill JA, Wang ZV, Circ Res 2022 May 101161CIRCRESAHA122321050

Integrated Stress Response Couples Mitochondrial Protein Translation with Oxidative Stress Control.

Zhang G, Wang X, Li C, Li Q, An YA, Luo X, Deng Y, Gillette TG, Scherer PE, Wang ZV, Circulation 2021 Sep

PKM1 Exerts Critical Roles in Cardiac Remodeling Under Pressure Overload in the Heart.

Li Q, Li C, Elnwasany A, Sharma G, An YA, Zhang G, Elhelaly WM, Lin J, Gong Y, Chen G, Wang MH, Zhao S, Dai C, Smart CD, Liu J, Luo X, Deng Y, Tan L, Lv SJ, Davidson SM, Locasale JW, Lorenzi PL, Malloy CR, Gillette TG, Vander Heiden MG, Scherer PE, Szweda LI, Fu G, Wang ZV, Circulation 2021 Jun

Cooperative Binding of ETS2 and NFAT Link Erk1/2 and Calcineurin Signaling in the Pathogenesis of Cardiac Hypertrophy.

Luo Y, Jiang N, May HI, Luo X, Ferdous A, Schiattarella GG, Chen G, Li Q, Li C, Rothermel BA, Jiang D, Lavandero S, Gillette TG, Hill JA, Circulation 2021 Apr

• American Diabetes Association Postdoctoral Fellowship Award