Biography

Our lab is interested in addressing a fundamental question of cell biology: How are organelles spatially organized? Mitochondria are especially fascinating to us because they perform a multitude of cellular functions that are dependent on the elaborate organization of their double membrane bilayer. In particular, mitochondrial energy production is directly linked to the shape of the organelle’s hallmark cristae membranes, which house the respiratory complexes that perform oxidative phosphorylation. We aim to elucidate the mechanisms that govern cristae organization within mitochondria and determine how cristae can dynamically remodel depending on cellular metabolic demand.

 

2012-2017 Postdoc, Cell and Molecular Biology, University of California Davis

2007-2012 Ph.D., Molecular Cell and Devolpmental Biology, University of Colorado Boulder

2001-2005 Bachelor of Arts, Biology, Washington University in St. Louis

Research Interest

  • Research

Publications

Featured Publications LegendFeatured Publications

Mitochondrial hepato-encephalopathy due to deficiency of QIL1/MIC13 (C19orf70), a MICOS complex subunit.
Zeharia A, Friedman JR, Tobar A, Saada A, Konen O, Fellig Y, Shaag A, Nunnari J, Elpeleg O Eur. J. Hum. Genet. 2016 12 24 12 1778-1782
MICOS and phospholipid transfer by Ups2-Mdm35 organize membrane lipid synthesis in mitochondria.
Aaltonen MJ, Friedman JR, Osman C, Salin B, di Rago JP, Nunnari J, Langer T, Tatsuta T J. Cell Biol. 2016 Jun 213 5 525-34
ER exit sites are physical and functional core autophagosome biogenesis components.
Graef M, Friedman JR, Graham C, Babu M, Nunnari J Mol. Biol. Cell 2013 Sep 24 18 2918-31
Identification of the DotL coupling protein subcomplex of the Legionella Dot/Icm type IV secretion system.
Vincent CD, Friedman JR, Jeong KC, Sutherland MC, Vogel JP Mol. Microbiol. 2012 Jul 85 2 378-91

Honors & Awards

  • NIH Pathway to Independence Award (K99/R00)
    (2016-2018)
  • ASCB Beckman Coulter Distinguished Graduate Student Achievement Prize
    (2013)
  • Harold Weintraub Graduate Student Award
    (2012)
  • Jane Coffin Childs Memorial Fund Postdoctoral Fellowship
    (2012-2015)