Education
Undergraduate
(1981), Biochemistry
Graduate School
(1985), Biochemistry
Graduate School
Wayne State University (1992), Chemistry

Publications
DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability
Huang Y, Lu C, Wang H, Gu L, Fu YX, Li GM Nature communications 2023 Dec 14
The mismatch recognition protein MutSα promotes nascent strand degradation at stalled replication forks
Zhang J, Zhao X, Liu L, Li HD, Gu L, Castrillon DH, Li GM Proceedings of the National Academy of Sciences of the United States of America 2022 Oct 119
Interplay between H3K36me3, methyltransferase SETD2, and mismatch recognition protein MutSα facilitates processing of oxidative DNA damage in human cells
Guo S, Fang J, Xu W, Ortega J, Liu CY, Gu L, Chang Z, Li GM Journal of Biological Chemistry 2022 Jul 298
DNA polymerase θ promotes CAG CTG repeat expansions in Huntington’s disease via insertion sequences of its catalytic domain
Chan KY, Li X, Ortega J, Gu L, Li GM Journal of Biological Chemistry 2021 Oct 297
Mispair-bound human MutS–MutL complex triggers DNA incisions and activates mismatch repair
Ortega J, Lee GS, Gu L, Yang W, Li GM Cell Research 2021 May 31 542-553
MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway
Guan J, Lu C, Jin Q, Lu H, Chen X, Tian L, Zhang Y, Ortega J, Zhang J, Siteni S, Chen M, Gu L, Shay JW, Davis AJ, Chen ZJ, Fu YX, Li GM Cancer Cell 2021 Jan 39 109-121.e5
OTUB1 stabilizes mismatch repair protein MSH2 by blocking ubiquitination
Wu Q, Huang Y, Gu L, Chang Z, Li GM Journal of Biological Chemistry 2021 Jan 296
Author Correction: Identification of novel genetic variants predisposing to familial oral squamous cell carcinomas (Cell Discovery, (2019), 5, 1, (57), 10.1038/s41421-019-0126-6)
Huang Y, Zhao J, Mao G, Lee GS, Zhang J, Bi L, Gu L, Chang Z, Valentino J, Li GM Cell Discovery 2020 Dec 6
Erratum: Phosphorylation of proliferating cell nuclear antigen promotes cancer progression by activating the ATM/Akt/GSK3β/Snail signaling pathway (J. Biol. Chem. (2019) 294 (7037-7045) DOI: 10.1074/jbc.RA119.007897)
Peng B, Ortega Rodriguez J, Gu L, Chang Z, Li G Journal of Biological Chemistry 2020 Jul 295 9767
Identification of novel genetic variants predisposing to familial oral squamous cell carcinomas
Huang Y, Zhao J, Mao G, Lee GS, Zhang J, Bi L, Gu L, Chang Z, Valentino J, Li GM Cell Discovery 2019 Dec 5