
Liya Gu, Ph.D.
Professor
School Medical School
Department Radiation Oncology
Education
- Undergraduate
- (1981), Biochemistry
- Graduate School
- (1985), Biochemistry
- Graduate School
- Wayne State University (1992), Chemistry
Publications
- DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability
- Huang Y, Lu C, Wang H, Gu L, Fu YX, Li GM Nature communications 2023 Dec 14
- The mismatch recognition protein MutSα promotes nascent strand degradation at stalled replication forks
- Zhang J, Zhao X, Liu L, Li HD, Gu L, Castrillon DH, Li GM Proceedings of the National Academy of Sciences of the United States of America 2022 Oct 119
- Interplay between H3K36me3, methyltransferase SETD2, and mismatch recognition protein MutSα facilitates processing of oxidative DNA damage in human cells
- Guo S, Fang J, Xu W, Ortega J, Liu CY, Gu L, Chang Z, Li GM Journal of Biological Chemistry 2022 Jul 298
- DNA polymerase θ promotes CAG CTG repeat expansions in Huntington’s disease via insertion sequences of its catalytic domain
- Chan KY, Li X, Ortega J, Gu L, Li GM Journal of Biological Chemistry 2021 Oct 297
- Mispair-bound human MutS–MutL complex triggers DNA incisions and activates mismatch repair
- Ortega J, Lee GS, Gu L, Yang W, Li GM Cell Research 2021 May 31 542-553
- MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway
- Guan J, Lu C, Jin Q, Lu H, Chen X, Tian L, Zhang Y, Ortega J, Zhang J, Siteni S, Chen M, Gu L, Shay JW, Davis AJ, Chen ZJ, Fu YX, Li GM Cancer Cell 2021 Jan 39 109-121.e5
- OTUB1 stabilizes mismatch repair protein MSH2 by blocking ubiquitination
- Wu Q, Huang Y, Gu L, Chang Z, Li GM Journal of Biological Chemistry 2021 Jan 296
- Author Correction: Identification of novel genetic variants predisposing to familial oral squamous cell carcinomas (Cell Discovery, (2019), 5, 1, (57), 10.1038/s41421-019-0126-6)
- Huang Y, Zhao J, Mao G, Lee GS, Zhang J, Bi L, Gu L, Chang Z, Valentino J, Li GM Cell Discovery 2020 Dec 6
- Erratum: Phosphorylation of proliferating cell nuclear antigen promotes cancer progression by activating the ATM/Akt/GSK3β/Snail signaling pathway (J. Biol. Chem. (2019) 294 (7037-7045) DOI: 10.1074/jbc.RA119.007897)
- Peng B, Ortega Rodriguez J, Gu L, Chang Z, Li G Journal of Biological Chemistry 2020 Jul 295 9767
- Identification of novel genetic variants predisposing to familial oral squamous cell carcinomas
- Huang Y, Zhao J, Mao G, Lee GS, Zhang J, Bi L, Gu L, Chang Z, Valentino J, Li GM Cell Discovery 2019 Dec 5