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Todd Aguilera, M.D.,  Ph.D.

Todd Aguilera, M.D., Ph.D.

Titles and Appointments

Assistant Professor

School
Medical School
Department
Radiation Oncology
Graduate Programs
Cancer Biology, Immunology

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For more information on the doctor and patient care, please visit the clinical profile.

  • Biography

    Todd Aguilera, M.D., Ph.D., is a physician-scientist trained as a radiation oncologist with expertise in molecular engineering, molecular imaging, the tumor microenvironment, and tumor immunology. He completed the Medical Scientist Training Program in 2011 at the University of California San Diego. He obtained his Ph.D. in 2009 in Dr. Roger Y. Tsien's laboratory, who received the 2008 Nobel Prize in Chemistry. His graduate work focused engineering and validating activatable peptide based probes to target the tumor microenvironment. Molecules that stemmed from his work are currently being tested in clinical trials for fluorescence guided surgery of breast cancer.

    After an internal medicine internship in San Diego, he joined the Radiation Oncology Residency Program at Stanford University. He worked with Dr. Amato Giaccia as a resident and postdoctoral fellow studying factors in the tumor microenvironment that promote immunologic tolerance and developing therapeutic approaches to improve immunotherapy responses in solid tumors. More specifically, he is interested is intrinsic factors that prevent/suppress the anti-tumor immune response after radiation and how these factors can be reversed. 

    Dr. Aguilera was recruited to the Department of Radiation Oncology to establish his research group who will continue investigate the immune microenvironment and engineer approaches to target cells and molecules that lead to immune privilege. He treats radiation oncology patients with gastrointestinal cancers, is developing laboratory projects in pancreatic cancer, and aims to establish collaborative projects with clinicians and researchers.

  • Education
    Other Post Graduate Training
    UC San Diego School of Medicine (2007)
    Graduate School
    UC San Diego School of Medicine (2007)
    Medical School
    UC San Diego School of Medicine (2011)
    Internship
    UC San Diego Medical Center (2012), Internal Medicine
    Residency
    Stanford University Medical Center (2016), Radiation Oncology
    Fellowship
    Stanford University Medical Center (2017), Gastrointestinal Radiation Oncology
  • Publications
    Defective homologous recombination and genomic instability predict increased responsiveness to carbon ion radiotherapy in pancreatic cancer
    Sishc BJ, Saha J, Alves EM, Ding L, Lu H, Wang SY, Swancutt KL, Nicholson JH, Facoetti A, Pompos A, Ciocca M, Aguilera TA, Story MD, Davis AJ npj Precision Oncology 2025 Dec 9
    Evolving Paradigms in the Treatment of Oligometastatic Pancreatic Ductal Adenocarcinoma
    Chang E, Sherry AD, Liermann J, Abdollahi A, Tzeng CW, Tang C, Aguilera TA, Koay EJ, Das P, Koong AC, Pant S, Ludmir EB Journal of Gastrointestinal Cancer 2025 Dec 56
    Internal Target Volume Estimation for Liver Cancer Radiation Therapy Using an Ultra Quality 4-Dimensional Magnetic Resonance Imaging
    Liao YP, Xiao H, Wang P, Li T, Aguilera TA, Visak JD, Godley AR, Zhang Y, Cai J, Deng J Advances in Radiation Oncology 2025 Jun 10
    NRG Oncology International Consensus Contouring Atlas on Target Volumes and Dosing Strategies for Dose-Escalated Pancreatic Cancer Radiation Therapy
    Sanford NN, Narang AK, Aguilera TA, Bassetti MF, Chuong MD, Erickson BA, Goodman KA, Herman JM, Intven M, Kilcoyne A, Kim H, Paulson E, Reyngold M, Tsai S, Tchelebi LT, Tuli R, Versteijne E, Wei AC, Wo JY, Zhang Y, Hong TS, Hall WA International Journal of Radiation Oncology Biology Physics 2025 Mar 121 918-929
    Proceedings of the National Cancer Institute Workshop on combining immunotherapy with radiotherapy: challenges and opportunities for clinical translation
    Morris ZS, Demaria S, Monjazeb AM, Formenti SC, Weichselbaum RR, Welsh J, Enderling H, Schoenfeld JD, Brody JD, McGee HM, Mondini M, Kent MS, Young KH, Galluzzi L, Karam SD, Theelen WS, Chang JY, Huynh MA, Daib A, Pitroda S, Chung C, Serre R, Grassberger C, Deng J, Sodji QH, Nguyen AT, Patel RB, Krebs S, Kalbasi A, Kerr C, Vanpouille-Box C, Vick L, Aguilera TA, Ong IM, Herrera F, Menon H, Smart DD, Ahmed J, Gartrell RD, Roland CL, Fekrmandi F, Chakraborty B, Bent EH, Berg TJ, Hutson A, Khleif S, Sikora AG, Fong L The Lancet Oncology 2025 Mar 26 e152-e170
    ASO Visual Abstract: Delta Radiomic Features Predict Resection Margin Status and Overall Survival in Neoadjuvant-Treated Pancreatic Cancer Patients
    Wang K, Karalis JD, Elamir A, Bifolco A, Wachsmann M, Capretti G, Spaggiari P, Enrico S, Balasubramanian K, Fatimah N, Pontecorvi G, Nebbia M, Yopp A, Kaza R, Pedrosa I, Zeh H, Polanco P, Zerbi A, Wang J, Aguilera T, Ligorio M Annals of Surgical Oncology 2024 Apr 31 2664-2665
    Delta Radiomic Features Predict Resection Margin Status and Overall Survival in Neoadjuvant-Treated Pancreatic Cancer Patients
    Wang K, Karalis JD, Elamir A, Bifolco A, Wachsmann M, Capretti G, Spaggiari P, Enrico S, Balasubramanian K, Fatimah N, Pontecorvi G, Nebbia M, Yopp A, Kaza R, Pedrosa I, Zeh H, Polanco P, Zerbi A, Wang J, Aguilera T, Ligorio M Annals of Surgical Oncology 2024 Apr 31 2608-2620
    AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer
    Marquez-Palencia M, Herrera LR, Parida PK, Ghosh S, Kim K, Das NM, Gonzalez-Ericsson PI, Sanders ME, Mobley BC, Diegeler S, Aguilera TA, Peng Y, Lewis CM, Arteaga CL, Hanker AB, Whitehurst AW, Lorens JB, Brekken RA, Davis AJ, Malladi S Cancer research 2024 Mar 84 675-687
    Stereotactic body radiotherapy plus rucosopasem in locally advanced or borderline resectable pancreatic cancer: GRECO-2 phase II study design
    Hoffe SE, Aguilera TA, Parikh PJ, Ghaly MM, Herman JM, Caster JM, Kim DW, Costello J, Malafa MP, Moser EC, Kennedy EP, Terry K, Kurman M Future Oncology 2024 20 437-446
    Stereotactic body radiotherapy with or without selective dismutase mimetic in pancreatic adenocarcinoma: an adaptive, randomised, double-blind, placebo-controlled, phase 1b/2 trial
    Taniguchi CM, Frakes JM, Aguilera TA, Palta M, Czito B, Bhutani MS, Colbert LE, Abi Jaoude J, Bernard V, Pant S, Tzeng CW, Kim DW, Malafa M, Costello J, Mathew G, Rebueno N, Koay EJ, Das P, Ludmir EB, Katz MH, Wolff RA, Beddar S, Sawakuchi GO, Moningi S, Slack Tidwell RS, Yuan Y, Thall PF, Beardsley RA, Holmlund J, Herman JM, Hoffe SE The Lancet Oncology 2023 Dec 24 1387-1398
  • Honors & Awards
    • ACS Brightedge Accelerator Award
      American Cancer Society (2024-2025)
    • Pancreatic Cancer Translational Pilot Award
      UT Southwestern Simmons Comprehensive Cancer Center (2024)
    • Cancer Moonshots Scholar
      National Cancer Institute (2023)
    • Cancer Immunotherapy: Decoding the Cancer Immunity Interactome Travel Award
      Keystone Symposia (2022)
    • Early Career Investigator Travel Award
      Radiation Research Society (2022)
    • Texas Super Doctors
      Rising Star (2021)
    • UT Southwestern Translational Research Award
      UT Southwestern Simmons Comprehensive Cancer Center (2021-2022)
    • Damon Runyon Clinical Investigator Research Award
      Damon Runyon Cancer Research Foundation (2020-2023)
    • Texas Super Doctors
      Rising Star (2020)
    • Shelby Award for Pancreatic Cancer Research
      Shelby Foundation via UT Southwestern (2019-2021)
    • UT Southwestern Distinguished Researcher Award
      Presidents Research Council UT Southwestern (2018-2019)
    • CPRIT First-time Tenure Track Faculty Recruitment Award
      UT Southwestern (2017-2021)
    • Henry S. Kaplan Fellow Training Grant
      Stanford Department of Radiation Oncology (2016-2017)
  • Professional Associations/Affiliations
    • American Association for Cancer Research (2012)
    • American Society for Radiation Oncology (2011)
    • American Society of Clinical Oncology (2013)
    • Radiological Society of North America (2011-2017)
    • Society for Immunotherapy of Cancer (2015)