Sachie Ogawa, Ph.D. Titles and Appointments Assistant Professor School Medical School Department Psychiatry Graduate Programs Neuroscience Biography Dr. Ogawa received a bachleor's degree in Biology from Kitasato University in Japan, and master degree in Biology from Kyushu University in Japan. She obtained her Ph.D. in Medical Science from Kurume University, where she studied physiological mechanisms of hippocampal neurons effected by volatile anesthetics using in vitro electrophysiological technique (Ogawa et al., Neuropharmacology, 2011). After an assistant professor at Kumamoto Health Science University in Japan, she conducted neural circuits connectome for neuromodulators, as a Postdoctoral Fellow at Department of Molecular and Cellular biology in Harvard University. She used modified rabies virus technique combined with transgenic mice to enable to trace cell-type specific input to two major neuromodulators, serotonin and dopamine which play important roles for flexible behaviors (Ogawa et al, Cell Reports, 2014). After that, as a Postdoctoral Associate at the Picower Institute for Learning and Memory in MIT, she studied specific neuronal circuits how memory is processed in the brain (Kitamura, Ogawa, and Roy et al., Science 2017). Dr. Ogawa joined the Department of Psychiatry in 2017. Research Interest Circuit dissections for learning related neuronal organizations Global neuronal activity for memory Regulation of neurotransmitter mechanisms Publications Featured Publications Combinative Protein Expression of Immediate Early Genes c-Fos, Arc, and Npas4 Along Aversive and Appetitive Experience-Related Neural Networks. Arai M, Osanai H, Snell CC, Gawf KE, Kitamura T, Ogawa SK, Hippocampus 2025 Sep 35 5 e70030 Outer layer of Vb neurons in medial entorhinal cortex project to hippocampal dentate gyrus in mice. Yamamoto N, Yokose J, Ramesh K, Kitamura T, Ogawa SK, Mol Brain 2024 Feb 17 1 5 Brain-wide mapping reveals that engrams for a single memory are distributed across multiple brain regions. Roy DS, Park YG, Kim ME, Zhang Y, Ogawa SK, DiNapoli N, Gu X, Cho JH, Choi H, Kamentsky L, Martin J, Mosto O, Aida T, Chung K, Tonegawa S, Nat Commun 2022 Apr 13 1 1799 Organization of dopamine and serotonin system: Anatomical and functional mapping of monosynaptic inputs using rabies virus. Ogawa SK, Watabe-Uchida M Pharmacol. Biochem. Behav. 2017 May Engrams and circuits crucial for systems consolidation of a memory. Kitamura T, Ogawa SK, Roy DS, Okuyama T, Morrissey MD, Smith LM, Redondo RL, Tonegawa S Science 2017 Apr 356 6333 73-78 Organization of monosynaptic inputs to the serotonin and dopamine neuromodulatory systems. Ogawa SK, Cohen JY, Hwang D, Uchida N, Watabe-Uchida M Cell Rep 2014 Aug 8 4 1105-18 Volatile anesthetic effects on isolated GABA synapses and extrasynaptic receptors. Ogawa SK, Tanaka E, Shin MC, Kotani N, Akaike N Neuropharmacology 2011 Mar 60 4 701-10 Automated detection of c-Fos-expressing neurons using inhomogeneous background subtraction in fluorescent images. Osanai H, Arai M, Kitamura T, Ogawa SK, Neurobiol Learn Mem 2025 Feb 218 108035 Roles of mediodorsal thalamus in observational fear-related neural activity in mouse anterior cingulate cortex. Ramesh K, Nair IR, Yamamoto N, Ogawa SK, Terranova JI, Kitamura T, Mol Brain 2025 Feb 18 1 14 Optogenetic activation of dopamine D1 receptors in island cells of medial entorhinal cortex inhibits temporal association learning. Yokose J, Yamamoto N, Ogawa SK, Kitamura T, Mol Brain 2023 Nov 16 1 78 Results 1-10 of 28 1 2 3 Next Last Professional Associations/Affiliations Association for Neurons and Brain Disease (2014) Physiological Society of Japan (2010) Society for Japanese Neuroscience (2014) Society for Neuroscience (2011)
