David Busch, Ph.D.

Undergraduate

Saint John's University (2001), Physics

Graduate School

University of Pennsylvania (2011), Physics

• Biomedical engineering
• Brain and spinal cord monitoring
• Cerebral metabolism and hemodynamics
• Diffuse correlation spectroscopy (DCS)
• Diffuse optical spectroscopy (DOS)
• Intraoperative neuromonitoring
• Medical device development
• Near-infrared spectroscopy (NIRS)
• Non-invasive monitoring
• Spinal cord hemodynamics

Featured Publications

Towards rapid intraoperative axial localization of spinal cord ischemia with epidural diffuse correlation monitoring.

Busch DR, Lin W, Goh CC, Gao F, Larson N, Wahl J, Bilfinger TV, Yodh AG, Floyd TF, PLoS One 2021 16 5 e0251271

Detection of Brain Hypoxia Based on Noninvasive Optical Monitoring of Cerebral Blood Flow with Diffuse Correlation Spectroscopy.

Busch DR, Balu R, Baker WB, Guo W, He L, Diop M, Milej D, Kavuri V, Amendolia O, St Lawrence K, Yodh AG, Kofke WA Neurocrit Care 2018 Jul

Continuous cerebral hemodynamic measurement during deep hypothermic circulatory arrest.

Busch DR, Rusin CG, Miller-Hance W, Kibler K, Baker WB, Heinle JS, Fraser CD, Yodh AG, Licht DJ, Brady KM Biomed Opt Express 2016 Sep 7 9 3461-3470

Cerebral Blood Flow Response to Hypercapnia in Children with Obstructive Sleep Apnea Syndrome.

Busch DR, Lynch JM, Winters ME, McCarthy AL, Newland JJ, Ko T, Cornaglia MA, Radcliffe J, McDonough JM, Samuel J, Matthews E, Xiao R, Yodh AG, Marcus CL, Licht DJ, Tapia IE Sleep 2016 Jan 39 1 209-16

Peripheral microcirculatory alterations are associated with the severity of acute respiratory distress syndrome in COVID-19 patients admitted to intermediate respiratory and intensive care units.

Mesquida J, Caballer A, Cortese L, Vila C, Karadeniz U, Pagliazzi M, Zanoletti M, Pacheco AP, Castro P, García-de-Acilu M, Mesquita RC, Busch DR, Durduran T, Crit Care 2021 11 25 1 381

Performance Assessment of a Commercial Continuous-Wave Near-Infrared Spectroscopy Tissue Oximeter for Suitability for Use in an International, Multi-Center Clinical Trial.

Cortese L, Zanoletti M, Karadeniz U, Pagliazzi M, Yaqub MA, Busch DR, Mesquida J, Durduran T, Sensors (Basel) 2021 Oct 21 21

Association of ongoing cerebral oxygen extraction during deep hypothermic circulatory arrest with post-operative brain injury.

Lynch JM, Mavroudis CD, Ko TS, Jacobwitz M, Busch DR, Xiao R, Nicolson SC, Montenegro LM, Gaynor JW, Yodh AG, Licht DJ, Semin Thorac Cardiovasc Surg 2021 Sep

Effects of circulatory arrest and cardiopulmonary bypass on cerebral autoregulation in neonatal swine.

Padawer-Curry JA, Volk LE, Mavroudis CD, Ko TS, Morano VC, Busch DR, Rosenthal TM, Melchior RW, Shade BC, Schiavo KL, Boorady TW, Schmidt AL, Andersen KN, Breimann JS, Jahnavi J, Mensah-Brown KG, Yodh AG, Mascio CE, Kilbaugh TJ, Licht DJ, White BR, Baker WB, Pediatr Res 2021 May

Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease.

Gregori-Pla C, Mesquita RC, Favilla CG, Busch DR, Blanco I, Zirak P, Frisk LK, Avtzi S, Maruccia F, Giacalone G, Cotta G, Camps-Renom P, Mullen MT, Martí-Fàbregas J, Prats-Sánchez L, Martínez-Domeño A, Kasner SE, Greenberg JH, Zhou C, Edlow BL, Putt ME, Detre JA, Yodh AG, Durduran T, Delgado-Mederos R, BMC Neurol 2021 Apr 21 1 154

Breast cancer differential diagnosis using diffuse optical spectroscopic imaging and regression with z-score normalized data.

Cochran JM, Leproux A, Busch DR, O'Sullivan TD, Yang W, Mehta RS, Police AM, Tromberg BJ, Yodh AG, J Biomed Opt 2021 Feb 26 2

 Featured Books

Diffuse Optical Tomography and Spectroscopy. In Molecular Imaging: Principles and Practice

David R Busch and Britton Chance (2009). BC Decker

• Mack Technology Fellow
  (2017-2017)
• Fulbright Scholar
  University of Campinas (UNICAMP) Brazil (2015-2016)
• Whitaker Scholar
  ICFO- The Institute of Photonic Sciences, Barcelona Spain (2014-2015)

• American Society for Laser Medicine and Surgery (2017)
• International Society of Cerebral Blood Flow and Metabolism (2016)
• Optical Society of America (2001)
• SPIE (2002)