Saint John's University (2001), Physics
Graduate School
University of Pennsylvania (2011), Physics

Research Interest

  • Biomedical engineering
  • Brain and spinal cord monitoring
  • Cerebral metabolism and hemodynamics
  • Diffuse correlation spectroscopy (DCS)
  • Diffuse optical spectroscopy (DOS)
  • Intraoperative neuromonitoring
  • Medical device development
  • Near-infrared spectroscopy (NIRS)
  • Non-invasive monitoring
  • Spinal cord hemodynamics


Featured Publications LegendFeatured Publications

Early microvascular cerebral blood flow response to head-of-bed elevation is related to outcome in acute ischemic stroke.
Gregori-Pla C, Blanco I, Camps-Renom P, Zirak P, Serra I, Cotta G, Maruccia F, Prats-Sánchez L, Martínez-Domeño A, Busch DR, Giacalone G, Martí-Fàbregas J, Durduran T, Delgado-Mederos R J. Neurol. 2019 Feb
Hybrid time-domain and continuous-wave diffuse optical tomography instrument with concurrent, clinical magnetic resonance imaging for breast cancer imaging.
Cochran JM, Busch DR, Lin L, Minkoff DL, Schweiger M, Arridge S, Yodh AG J Biomed Opt 2019 Jan 24 5 1-11
Non-invasive optical neuromonitoring of the temperature-dependence of cerebral oxygen metabolism during deep hypothermic cardiopulmonary bypass in neonatal swine.
Ko TS, Mavroudis CD, Baker WB, Morano VC, Mensah-Brown K, Boorady TW, Schmidt AL, Lynch JM, Busch DR, Gentile J, Bratinov G, Lin Y, Jeong S, Melchior RW, Rosenthal TM, Shade BC, Schiavo KL, Xiao R, Gaynor JW, Yodh AG, Kilbaugh TJ, Licht DJ J. Cereb. Blood Flow Metab. 2018 Oct 271678X18809828
Tissue oxygen saturation predicts response to breast cancer neoadjuvant chemotherapy within 10 days of treatment.
Cochran JM, Busch DR, Leproux A, Zhang Z, O'Sullivan TD, Cerussi AE, Carpenter PM, Mehta RS, Roblyer D, Yang W, Paulsen KD, Pogue B, Jiang S, Kaufman PA, Chung SH, Schnall M, Snyder BS, Hylton N, Carp SA, Isakoff SJ, Mankoff D, Tromberg BJ, Yodh AG J Biomed Opt 2018 Oct 24 2 1-11
Noninvasive continuous optical monitoring of absolute cerebral blood flow in critically ill adults.
He L, Baker WB, Milej D, Kavuri VC, Mesquita RC, Busch DR, Abramson K, Jiang JY, Diop M, St Lawrence K, Amendolia O, Quattrone F, Balu R, Kofke WA, Yodh AG Neurophotonics 2018 Oct 5 4 045006
Laser safety in fiber-optic monitoring of spinal cord hemodynamics: a preclinical evaluation.
Busch DR, Davis J, Kogler A, Galler RM, Parthasarathy AB, Yodh AG, Floyd TF J Biomed Opt 2018 Jun 23 6 1-9
Preoperative cerebral hemodynamics from birth to surgery in neonates with critical congenital heart disease.
Lynch JM, Ko T, Busch DR, Newland JJ, Winters ME, Mensah-Brown K, Boorady TW, Xiao R, Nicolson SC, Montenegro LM, Gaynor JW, Spray TL, Yodh AG, Naim MY, Licht DJ J. Thorac. Cardiovasc. Surg. 2018 May


Featured Books Legend Featured Books

Diffuse Optical Tomography and Spectroscopy. In Molecular Imaging: Principles and Practice

David R Busch and Britton Chance (2009). BC Decker

Honors & Awards

  • Mack Technology Fellow
  • Fulbright Scholar
    University of Campinas (UNICAMP) Brazil (2015-2016)
  • Whitaker Scholar
    ICFO- The Institute of Photonic Sciences, Barcelona Spain (2014-2015)

Professional Associations/Affiliations

  • American Society for Laser Medicine and Surgery (2017)
  • International Society of Cerebral Blood Flow and Metabolism (2016)
  • SPIE (2002)
  • Optical Society of America (2001)