David Busch, Ph.D.

Dr. Busch’s work focuses on developing non-invasive and minimally invasive optical tools to monitor deep tissues in health and disease, as well as throughout therapy.

He received a Ph.D. from the University of Pennsylvania (Physics) in 2011 and completed a postdoctoral fellowship in Neurology at the Children's Hospital of Philadelphia, prior to joining the faculty at the University of Texas Southwestern Medical Center in 2018. Dr. Busch is currently an assistant professor in the Departments of Anesthesiology and Pain Management, Neurology, and Biomedical Engineering, as well as a member of the Biomedical Engineering and Neuroscience Graduate Programs. 

Dr. Busch’s research is currently supported by NIH NINDS  and NIBIB and formerly by the Fulbright, Thrasher, and Hartwell Research Foundations.

Undergraduate

Saint John's University (2001), Physics

Graduate School

University of Pennsylvania (2011), Physics

• Biomedical engineering
• Brain and spinal cord monitoring
• Cerebral metabolism and hemodynamics
• Diffuse correlation spectroscopy (DCS)
• Diffuse optical spectroscopy (DOS)
• Intraoperative neuromonitoring
• Medical device development
• Near-infrared spectroscopy (NIRS)
• Non-invasive monitoring
• Spinal cord hemodynamics

Neuromonitoring of Pediatric and Adult Extracorporeal Membrane Oxygenation Patients: The Importance of Continuous Bedside Tools in Driving Neuroprotective Clinical Care

Tabet M, Custer C, Khan IR, Sanford E, Sharma J, Choe R, Singh S, Sirsi D, Olson DM, Morriss MC, Raman L, Busch DR ASAIO Journal 2024 Mar 70 167-176

Computed Tomography Is Predictive of Significant Neurologic Injury in Children Supported on Extracorporeal Membrane Oxygenation

Custer C, Singh S, Sanford E, Nandy K, Raman L, Busch DR, Morriss MC ASAIO Journal 2023 Nov 69 E460-E462

Association Between Disrupted Cerebral Autoregulation and Radiographic Neurologic Injury for Children on Extracorporeal Membrane Oxygenation: A Prospective Pilot Study

Sanford EL, Akorede R, Miller I, Morriss MC, Nandy K, Raman L, Busch DR ASAIO Journal 2023 Jul 69 E315-E321

Association of Ongoing Cerebral Oxygen Extraction During Deep Hypothermic Circulatory Arrest With Postoperative Brain Injury

Lynch JM, Mavroudis CD, Ko TS, Jacobwitz M, Busch DR, Xiao R, Nicolson SC, Montenegro LM, Gaynor JW, Yodh AG, Licht DJ Seminars in thoracic and cardiovascular surgery 2022 Dec 34 1275-1284

Non-invasive monitoring of blood oxygenation in human placentas via concurrent diffuse optical spectroscopy and ultrasound imaging

Wang L, Cochran JM, Ko T, Baker WB, Abramson K, He L, Busch DR, Kavuri V, Linn RL, Parry S, Yodh AG, Schwartz N Nature Biomedical Engineering 2022 Sep 6 1017-1030

Effects of circulatory arrest and cardiopulmonary bypass on cerebral autoregulation in neonatal swine

Padawer-Curry JA, Volk LE, Mavroudis CD, Ko TS, Morano VC, Busch DR, Rosenthal TM, Melchior RW, Shade BC, Schiavo KL, Boorady TW, Schmidt AL, Andersen KN, Breimann JS, Jahnavi J, Mensah-Brown KG, Yodh AG, Mascio CE, Kilbaugh TJ, Licht DJ, White BR, Baker WB Pediatric Research 2022 May 91 1374-1382

A Pilot Study Comparing Optically Measured Cerebral Autoregulation During Pediatric Extracorporeal Life Support and Neurological Injury

Sanford E, Akorede R, Miller I, Contreras G, Swalley N, Morriss MC, Raman L, Busch DR 2022

Evaluating the Endothelial Impairments in COVID-19 Patients Using Near-Infrared Spectroscopy: the HEMOCOVID-19 trial

Cortese L, De Oliveira LB, Bernardes Delazari LE, Buckley EM, Busch DR, Caballer A, Carbajal Robles V, Castro P, Cavallaro Barauna Lima AL, Cheruku S, Chiscano L, Choi C, Dave S, Do Nascimento B, Dos Santos Roceto Ratti L, Eiras Falcão AL, Espinal C, Fernández S, Ferrer R, Font F, Forti RM, De Acilu MG, Grasselli G, Gruartmoner G, Guzzardella A, Jabeen I, Karadeniz U, Lahsaei P, Lívio Emídio G, Marin Corral J, Matas A, Mesquita RC, Mera A, De Oca Hernández FJ, Myers T, Nogales S, Olson D, Pagliazzi M, Parada Guzmán M, Parrilla-Gómez FJ, Pérez Pacheco A, Pérez Terán P, Picazo Moreno L, Pineda Vázquez D, Quiroga Soto AF, Quispe Siccha RM, Romero D, Santillán Aguayo E, Serra I, Serrano Loyola R, Téllez A, Utino Taniguchi L, Vilà C, Weinmann M, Zanella A, Zanoletti M, Mesquida J, Durduran T 2022

Evaluating the Endothelial Impairments in COVID-19 Patients Using Near-Infrared Spectroscopy: the HEMOCOVID-19 trial

Cortese L, De Oliveira LB, Bernardes Delazari LE, Buckley EM, Busch DR, Caballer A, Carbajal Robles V, Castro P, Cavallaro Barauna Lima AL, Cheruku S, Chiscano L, Choi C, Dave S, Do Nascimento B, Dos Santos Roceto Ratti L, Eiras Falcão AL, Espinal C, Fernández S, Ferrer R, Font F, Forti RM, De Acilu MG, Grasselli G, Gruartmoner G, Guzzardella A, Jabeen I, Karadeniz U, Lahsaei P, Lívio Emídio G, Marin Corral J, Matas A, Mesquita RC, Mera A, De Oca Hernández FJ, Myers T, Nogales S, Olson D, Pagliazzi M, Parada Guzmán M, Parrilla-Gómez FJ, Pérez Pacheco A, Pérez Terán P, Picazo Moreno L, Pineda Vázquez D, Quiroga Soto AF, Quispe Siccha RM, Romero D, Santillán Aguayo E, Serra I, Serrano Loyola R, Téllez A, Utino Taniguchi L, Vilà C, Weinmann M, Zanella A, Zanoletti M, Mesquida J, Durduran T Optics InfoBase Conference Papers 2022

A Pilot Study Comparing Optically Measured Cerebral Autoregulation During Pediatric Extracorporeal Life Support and Neurological Injury

Sanford E, Akorede R, Miller I, Contreras G, Swalley N, Morriss MC, Raman L, Busch DR Optics InfoBase Conference Papers 2022

 Featured Books

Diffuse Optical Tomography and Spectroscopy. In Molecular Imaging: Principles and Practice

David R Busch and Britton Chance (2009). BC Decker

• Mack Technology Fellow
  (2017-2017)
• Fulbright Scholar
  University of Campinas (UNICAMP) Brazil (2015-2016)
• Whitaker Scholar
  ICFO- The Institute of Photonic Sciences, Barcelona Spain (2014-2015)

• American Society for Laser Medicine and Surgery (2017)
• International Society of Cerebral Blood Flow and Metabolism (2016)
• Optical Society of America (2001)
• SPIE (2002)