Dan Huang, M.D., Ph.D. Associate Professor School Medical School Department Cecil H. and Ida Green Center for Reproductive Biology Sciences | Obstetrics and Gynecology Biography Dan Huang is an Associate Professor in the Cecil H. and Ida Green Center for Reproductive Biology Sciences and the Department of Obstetrics and Gynecology. In 2009, Dr. Huang completed her M.D. and Ph.D. in Medicine at Tongji Medical College, Huazhong University of Science and Technology (HUST), China. She then worked as a cardiologist and clinician scientist in Wuhan Union Hospital, HUST. She was promoted to Associate Professor in 2012. She also spent time as a Visiting Assistant Professor at UT Southwestern from 2017 to 2021. In December 2024, Dr. Huang joined the faculty of UT Southwestern. Dr. Huang studies molecular mechanisms, cellular functions, and biology of histone modifications and chromatin regulation in physiology and diseases. Her research focuses on studying 1) molecular and cellular functions of ADP-ribosylation, as well as the PARP enzymes that catalyze the modification, (2) the inter-relationship network between histone post-translational modifications in chromatin regulation and 3) links between these mechanisms and biological outcomes, including cardiovascular and metabolic disorders, and cancers. Education Medical School Huazhong Univ of Sci & Tech (2004), Medicine Graduate School Huazhong Univ of Sci & Tech (2009), Internal Medicine Graduate School (2017), Internal Medicine Research Interest Cancer biology Cardiovascular disease Gene regulation Histone modification Metabolism Publications Featured Publications Functional Analysis of Histone ADP-Ribosylation In Vitro and in Cells. Huang D, Edwards AD, Gong X, Kraus WL, Methods Mol Biol 2023 2609 157-192 Oncohistone Mutations Occur at Functional Sites of Regulatory ADP-ribosylation. Huang D, Camacho CV, Martire S, Nagari A, Setlem R, Gong X, Edwards AD, Chiu SP, Banaszynski LA, Kraus WL, Cancer Res 2022 Apr The expanding universe of PARP1-mediated molecular and therapeutic mechanisms. Huang D, Kraus WL, Mol Cell 2022 Mar Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells. Palavalli Parsons LH, Challa S, Gibson BA, Nandu T, Stokes MS, Huang D, Lea JS, Kraus WL, Elife 2021 Jan 10 Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis. Huang D, Camacho CV, Setlem R, Ryu KW, Parameswaran B, Gupta RK, Kraus WL, Mol Cell 2020 09 79 6 934-949.e14 Specific Binding of snoRNAs to PARP-1 Promotes NAD+-Dependent Catalytic Activation. Huang D, Kim DS, Kraus WL, Biochemistry 2020 04 59 16 1559-1564 Yin and Yang Regulation of Liver X Receptor a Signaling Control of Cholesterol Metabolism by Poly(ADP-ribose) polymerase 1. Zhang F, Wang C, Jiang Y, Huang K, Liu F, Du M, Luo X, Huang D, Huang K, Int J Biol Sci 2020 16 15 2868-2882 The novel adipokine CTRP5 is a negative regulator of white adipose tissue browning. Rao C, Huang D, Mao X, Chen R, Huang D, Huang K Biochem. Biophys. Res. Commun. 2019 Mar 510 3 388-394 CTRP13 inhibits atherosclerosis via autophagy-lysosome-dependent degradation of CD36. Wang C, Xu W, Liang M, Huang D, Huang K FASEB J. 2018 Sep fj201801267RR Poly(ADP-ribosyl)ated PXR is a critical regulator of acetaminophen-induced hepatotoxicity. Wang C, Xu W, Zhang Y, Huang D, Huang K Cell Death Dis 2018 Jul 9 8 819 Results 1-10 of 25 1 2 3 Next Last
