Jonathan Uhr, M.D.

NAME: Jonathan W. Uhr POSITION TITLE: Professor of Internal Medicine Microbiology INSTITUTION AND LOCATION DEGREE (if applicable) YEAR(s) FIELD OF STUDY Rutgers Preparatory School 1944 Cornell University, New York A.B. 1948 New York University School of Medicine M.D. 1952 Medicine PROFESSIONAL EXPERIENCE: 1962 - 1968 Associate Professor of Medicine, New York University School of Medicine 1962 - 1972 Director, Irvington House Institute for Rheumatic Fever and Allied Diseases, New York University School of Medicine 1968 - 1972 Professor of Medicine, New York University School of Medicine 1972 - 1997 Professor and Chairman, Dept. of Microbiology and Professor of Internal Medicine, UT Southwestern Medical Center at Dallas 1997 - Professor of Cancer Immunobiology Center, Microbiology and Internal Medicine, Raymond and Ellen Willie Distinguished Chair in Cancer Research, UT Southwestern Medical Center at Dallas COMMITTEES: 1980 - 1989 Member, Scientific Review Board, Howard Hughes Medical Institute; 1981 - 1986 Member, U.S.-Japan Panel of the Cooperative Program in Immunology; 1983 - 1987 Member, Scripps Clinic Scientific Review Board; 1984 - 1985, President, American Association of Immunologists; 1984 - 1994 Advisory Editor, Immunological Reviews; 1993 - 1997 Member, Howard Hughes Medical Advisory Board; 1984 - present Associate Editor, Advances in Immunology. PROFESSIONAL SOCIETIES: American Association of Immunologists; American Association of Pathologists; American Society for Clinical Investigation; Transplantation Society; Association of American Physicians; American Society for Cancer Research AWARDS: Squibb Award, Infectious Diseases Society of America (1971); New York University Alumni Award for Achievement in the Basic Sciences (1978); National Academy of Sciences (1984); Fellow of the American Association for the Advancement of Science (1990); The Gibson D. Lewis Award for Cancer Control (Research Achievement); Texas Cancer Council (1991); American Academy of Arts and Sciences (1993); Abbott-American Society for Microbiology Life Time Achievement Award (1999). B. Selected peer-reviewed publications (in chronological order). Do not include publications submitted or in preparation. PUBLICATIONS (1995-2002; 382 total) 1. Farrar, J., K. Katz, J. Windsor, G. Thrush, R. Scheuermann, J. Uhr and N. Street. Cancer dormancy VII: A regulatory role for CD8+ T Cells and IFN-g in establishing and maintaining the tumor dormant state. Journ Immunol. 162:2842-2849, 1999. 2. Marches, R., R. Hseuh and J. Uhr. Cancer Dormancy VIII. Induction of p21WAF1 initiated by membrane IgM engagement increases survival of B lymphoma cells. Proc. Natl. Acad. Sci. USA 86:8711-8715, 1999. 3. Schindler J., Sausville, E., Messmann, R., Uhr, J.W., and Vitetta, E.S. The Toxicity of Deglycosylated Ricin A Chain-Containing Immunotoxins in Patients With Non-Hodgkin's Lymphoma is Exacerbated by Prior Radiotherapy: A Retrospective Analysis of Patients in Five Clinical Trials. Clinical Cancer Research, 7:255-258, 2001. 4. Marches, R., Vitetta, E.S. and Uhr, J.W. A role for intracellular pH in membrane IgM-mediated cell death of human B lymphomas. Proc. Natl. Acad. Sci. USA, 98(6): 3434-3439, 2001. 5. Spiridon, C.I., Ghetie, M-A., Uhr, J., Marches, R., Li, J-L., Shen, G-L. and Vitetta, E.S. Targeting Multiple Her-2 Epitopes with Monoclonal Antibodies Results in Improved Anti-Growth Activity of a Human Breast Cancer Cell Line In vitro and In vivo. Clinical Cancer Research, 8:1720-1730, 2002. 6. Fehm, T., Sagalowsky, A., Clifford, E., Beitsch, P., Saboorian, H., Euhus, D., Meng, S., Morrison, L., Tucker, T., Lane, N., Ghadimi, M., Heselmeyer-Hadad, K., Ried, T., Rao, C., Uhr, J. Cytogenetic Evidence that Circulating Epithelial Cells in Patients with Carcinoma are Malignant. Clinical Cancer Research, 8:2073-2084, 2002.

Undergraduate

Cornell University (1948)

Medical School

New York University (1952)

• HER-2
• Tumor dormancy

Featured Publications

Circulating tumor cells in patients with breast cancer dormancy

Meng, S., Tripathy, D., Frenkel, E., Shete, S., Naftalis, E., Huth, J., Beitsch, P., Leitch, M., Hoover, S., Euhus, D., Haley, B., Morrison, L., Fleming, T., Herlyn, D., Terstappen, L., Fehm, T., Tucker, T., Lane, N., Wang, J., and Uhr, J. Clinical Cancer Research 2004 10 8152-8162

The toxicity of deglycosylated ricin A-chain containing immunotoxins in patients with non-Hodgkin's lymphoma is exacerbated by prior radiotherapy: A retrospective analysis of patients in five clinical trials

J. Schindler, E. Sausville, R. Messmann, J.W. Uhr and E.S. Vitetta Clinical Cancer Research 7 255-258

The toxicity of deglycosylated ricin A-chain containing immunotoxins in patients with non-Hodgkin's lymphoma is exacerbated by prior radiotherapy: A retrospective analysis of patients in five clinical trials

J. Schindler, E. Sausville, R. Messmann, J.W. Uhr and E.S. Vitetta Clinical Cancer Research 7 255-258

Patterns of aneusomy for three chromosomes in individual cells from breast cancer tumors

T. Fehm, L. Morrison, H. Saboorian, L. Hynan, T. Tucker and J.W. Uhr Breast Cancer and Treatment 2002 2379 1-13

Cytogenetic evidence that circulating epithelial cells in patients with carcinoma are malignant

T. Fehm, A. Sagalowsky, E. Clifford, P. Beitsch, H. Saboorian, D. Euhus, S. Meng, L. Morrison, T. Tucker, N. Lane, M. Ghadimi, K. Heselmeyer-Hadad, T. Ried, C. Rao and J. W. Uhr Clinical Cancer Research 2002 8 2073-2084

Patterns of aneusomy for three chromosomes in individual cells from breast cancer tumors

T. Fehm, L. Morrison, H. Saboorian, L. Hynan, T. Tucker and J.W. Uhr Breast Cancer and Treatment 2002 2379 1-13

Cytogenetic evidence that circulating epithelial cells in patients with carcinoma are malignant

T. Fehm, A. Sagalowsky, E. Clifford, P. Beitsch, H. Saboorian, D. Euhus, S. Meng, L. Morrison, T. Tucker, N. Lane, M. Ghadimi, K. Heselmeyer-Hadad, T. Ried, C. Rao and J. W. Uhr Clinical Cancer Research 2002 8 2073-2084

A role for intracellular pH in membrane IgM-mediated cell death of human B lymphomas

R. Marches, E.S. Vitetta and J.W. Uhr PNAS 2001 98/6 3434-3439

A role for intracellular pH in membrane IgM-mediated cell death of human B lymphomas

R. Marches, E.S. Vitetta and J.W. Uhr PNAS 2001 98/6 3434-3439

Cancer dormancy VIII. Induction of p21WAF1 initiated by membrane IgM engagement increases survival of B lymphoma cells

R. Marches, R. Hseuh and J. Uhr PNAS 1999 86 8711-8715

• American Academy of Arts & Sciences
  (1993)
• American Assocation of Immunologists
  President (1984)
• National Academy of Sciences
  (1984)
• newcomb cleveland prize aaas
  (1966)