Biography

Dr. Shakkottai obtained his medical degree at the Christian Medical College, Vellore, India, and his PhD at the University of California, Irvine. He received his Neurology Residency training at Washington University/Barnes-Jewish hospital, and was a fellow in Movement Disorders at the University of Michigan. He joined the full-time faculty at University of Michigan in 2010. He moved to UTSW in 2021.

The long-term goal of Dr. Shakkottai’s clinical and laboratory research is to determine whether alterations in neuronal physiology contribute to motor dysfunction and to translate preclinical murine model research to human clinical trials for cerebellar ataxia. Work in Dr. Shakkottai’s laboratory has identified shared dysfunction in the cerebellum in murine models of ataxia, with identification of several ion channels that act in concert, and converging on large-conductance calcium-activated potassium (BK) channels.  BK channels are likely a key target for therapy in degenerative ataxias.

Dr. Shakkottai's Clinical Interests include: Cerebellar Ataxia, Inherited & Sporadic Disorders of Cerebellar Dysfunction, Balance Disorders and Other Movement Disorders.

Education

Medical School
Christian Medical College, India (2000)
Graduate School
University of California, Irvine (2004), Physiology & Biophysics
Internship
Washington University - Barnes Jewish Hospital (2005), Internal Medicine
Residency
Washington University/Barnes Jewish Hospital (2008)
Fellowship
University of Michigan Medical School (2010), Movement Disorders

Research Interest

  • Cerebellar Ataxia
  • Ion Channel Dysfunction
  • Potassium Channels
  • Purkinje Neuron
  • SCA

Publications

Featured Publications LegendFeatured Publications

Honors & Awards

  • Young Investigator Award, National Ataxia Foundation
    (2010)
  • Leonard Berg Award for resident research, Washington University School of Medicine
    (2008)
  • Dorothy Penrose Stout Award for the best predoctoral fellowship application in the Western States affiliate of the American Heart Association
    (2002)
  • Dr. Miriaviakulam David Memorial Medal for the best outgoing MBBS student of the graduating year of 2000, Christian Medical College, Vellore, India
    (1999)

Professional Associations/Affiliations

  • American Neurological Association (2012)
  • American Academy of Neurology (2006)