Vikram Shakkottai, M.D., Ph.D. Vice Chair for Basic Research, Section Head, Movement Disorders Professor Endowed Title Dedman Family Distinguished Chair in Neurological Disease School Medical School Department Neurology Graduate Programs Molecular Biophysics, Neuroscience You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Joined UT Southwestern: 2021 Clinical Interests: Vikram Shakkottai, M.D., Ph.D., sees patients with Cerebellar Ataxia, Inherited & Sporadic Disorders of Cerebellar Dysfunction, Balance Disorders, and Other Movement Disorders. Trainee Education: Dr. Shakkottai co-leads the Resident Research Track, for those residents who aspire to lead an independent career as a wet-bench or dry-bench researcher. Research: The long-term goal of Dr. Shakkottai’s clinical and laboratory research is to determine whether alterations in neuronal physiology contribute to motor dysfunction and degeneration in cerebellar ataxia. Work in Dr. Shakkottai’s laboratory has identified dysfunction in the cerebellum common to many murine models of ataxia, with the identification of ion channels regulating Purkinje neuron intrinsic excitability as key targets for a shared therapeutic strategy. Background: Dr. Shakkottai obtained his medical degree at the Christian Medical College, Vellore, India, and his PhD at the University of California, Irvine. He received his Neurology Residency training at Washington University/Barnes-Jewish Hospital and was a fellow in Movement Disorders at the University of Michigan. He joined the full-time faculty at the University of Michigan in 2010. Education Medical School Christian Medical College, India (2000) Graduate School University of California, Irvine (2004), Physiology & Biophysics Internship Washington University St. Louis - Barnes Jewish Hospital (2005), Internal Medicine Residency Washington University/Barnes Jewish Hospital (2008) Fellowship University of Michigan Medical School (2010), Movement Disorders Research Interest Cerebellar Ataxia Ion Channel Dysfunction Ion channel pharmacology and drug discovery Potassium Channels Purkinje Neuron SCA Publications Sensitivity of Advanced Magnetic Resonance Imaging to Progression over Six Months in Early Spinocerebellar Ataxia Author Collaboration RC, Rezende TJ, Petit E, Park YW, Tezenas du Montcel S, Joers JM, DuBois JM, Moore Arnold H, Povazan M, Banan G, Valabregue R, Ehses P, Faber J, Coupé P, Onyike CU, Barker PB, Schmahmann JD, Ratai EM, Subramony SH, Mareci TH, Bushara KO, Paulson H, Klockgether T, Durr A, Ashizawa T, Lenglet C, Öz G, Rosenthal L, Burns M, Grobe-Einsler M, Oender D, Koyak B, Kimmich O, Roy N, Coarelli G, Ewenczyk C, Heinzmann A, Lallemant P, Hurmic H, Wilmot G, Scorr L, Opal P, Sha S, Santini V, Sampson J, Perlman S, Geschwind M, Nelson A, Dietiker C, Gomez C, Shakkottai V Movement Disorders 2024 Oct 39 1856-1867 The Cerebellar Cognitive Affective/Schmahmann Syndrome Scale in Spinocerebellar Ataxias Selvadurai LP, Perlman SL, Ashizawa T, Wilmot GR, Onyike CU, Rosenthal LS, Shakkottai VG, Paulson HL, Subramony SH, Bushara KO, Kuo SH, Dietiker C, Geschwind MD, Nelson AB, Gomez CM, Opal P, Zesiewicz TA, Hawkins T, Yacoubian TA, Nopoulos PC, Sha SJ, Morrison PE, Figueroa KP, Pulst SM, Schmahmann JD Cerebellum 2024 Aug 23 1411-1425 SARA captures disparate progression and responsiveness in spinocerebellar ataxias Petit E, Schmitz-Hübsch T, Coarelli G, Jacobi H, Heinzmann A, Figueroa KP, Perlman SL, Gomez CM, Wilmot GR, Schmahmann JD, Ying SH, Zesiewicz TA, Paulson HL, Shakkottai VG, Bushara KO, Kuo SH, Geschwind MD, Xia G, Pulst SM, Subramony SH, Ewenczyk C, Brice A, Durr A, Klockgether T, Ashizawa T, Tezenas du Montcel S Journal of neurology 2024 Jul 271 3743-3753 ACR Appropriateness Criteria® Dizziness and Ataxia: 2023 Update Author Collaboration EP, Wang LL, Thompson TA, Shih RY, Ajam AA, Bulsara K, Burns J, Davis MA, Ivanidze J, Kalnins A, Kuo PH, Ledbetter LN, Pannell JS, Pollock JM, Shakkottai VG, Shih RD, Soares BP, Soderlund KA, Utukuri PS, Woolsey S, Policeni B Journal of the American College of Radiology 2024 Jun 21 S100-S125 Fatigue Impacts Quality of Life in People with Spinocerebellar Ataxias Lai RY, Rummey C, Amlang CJ, Lin CY, Chen TX, Perlman S, Wilmot G, Gomez CM, Schmahmann JD, Paulson H, Ying SH, Onyike CU, Zesiewicz TA, Bushara KO, Geschwind MD, Figueroa KP, Pulst SM, Subramony SH, Burns MR, Opal P, Duquette A, Ashizawa T, Hamedani AG, Davis MY, Srinivasan SR, Moore LR, Shakkottai VG, Rosenthal LS, Kuo SH Movement Disorders Clinical Practice 2024 May 11 496-503 Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1 Tejwani L, Ravindra NG, Lee C, Cheng Y, Nguyen B, Luttik K, Ni L, Zhang S, Morrison LM, Gionco J, Xiang Y, Yoon J, Ro H, Haidery F, Grijalva RM, Bae E, Kim K, Martuscello RT, Orr HT, Zoghbi HY, McLoughlin HS, Ranum LP, Shakkottai VG, Faust PL, Wang S, van Dijk D, Lim J Neuron 2024 Feb 112 362-383.e15 Deriving early single-rosette brain organoids from human pluripotent stem cells Tidball AM, Niu W, Ma Q, Takla TN, Walker JC, Margolis JL, Mojica-Perez SP, Sudyk R, Deng L, Moore SJ, Chopra R, Shakkottai VG, Murphy GG, Yuan Y, Isom LL, Li JZ, Parent JM Stem Cell Reports 2023 Dec 18 2498-2514 The S-Factor, a New Measure of Disease Severity in Spinocerebellar Ataxia: Findings and Implications Selvadurai LP, Perlman SL, Wilmot GR, Subramony SH, Gomez CM, Ashizawa T, Paulson HL, Onyike CU, Rosenthal LS, Sair HI, Kuo SH, Ratai EM, Zesiewicz TA, Bushara KO, Öz G, Dietiker C, Geschwind MD, Nelson AB, Opal P, Yacoubian TA, Nopoulos PC, Shakkottai VG, Figueroa KP, Pulst SM, Morrison PE, Schmahmann JD Cerebellum 2023 Oct 22 790-809 Genome-wide structural variant analysis identifies risk loci for non-Alzheimer's dementias Author Collaboration PC, Author Collaboration TA, Author Collaboration IL, Author Collaboration IA, Kaivola K, Chia R, Ding J, Rasheed M, Fujita M, Menon V, Walton RL, Collins RL, Billingsley K, Brand H, Talkowski M, Zhao X, Dewan R, Stark A, Ray A, Solaiman S, Alvarez Jerez P, Malik L, Dawson TM, Rosenthal LS, Albert MS, Pletnikova O, Troncoso JC, Masellis M, Keith J, Black SE, Ferrucci L, Resnick SM, Tanaka T, Soltis AR, Viollet C, Sukumar G, Alba C, Lott N, McGrath Martinez E, Tuck M, Singh J, Bacikova D, Zhang X, Hupalo DN, Adeleye A, Wilkerson MD, Pollard HB, Dalgard CL, Gan-Or Z, Rogaeva E, Brice A, Lesage S, Xiromerisiou G, Shakkottai VG Cell Genomics 2023 Jun 3 Targeting Ion Channels and Purkinje Neuron Intrinsic Membrane Excitability as a Therapeutic Strategy for Cerebellar Ataxia Huang H, Shakkottai VG Life 2023 Jun 13 Results 1-10 of 85 1 2 3 4 5 Next Last Honors & Awards John W Schut Research Achievement AwardNational Ataxia Foundation (2022) Young Investigator Award, National Ataxia Foundation (2010) Leonard Berg Award for resident research, Washington University School of Medicine (2008) Dorothy Penrose Stout Award for the best predoctoral fellowship application in the Western States affiliate of the American Heart Association (2002) Dr. Miriaviakulam David Memorial Medal for the best outgoing MBBS student of the graduating year of 2000, Christian Medical College, Vellore, India (1999) Professional Associations/Affiliations American Academy of Neurology (2006) American Neurological Association (2012)
